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When did you first realize you had a special interest and talent in1H-1,2,4-Triazol-5-amine

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lauar, MR; Blanch, GT; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or concate me.

In 2020.0 HYPERTENS RES published article about RENIN-ANGIOTENSIN SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANTEROVENTRAL 3RD-VENTRICLE AV3V; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; RENAL-HYPERTENSION; PRESSOR-RESPONSES; BLOOD-PRESSURE; RENOVASCULAR HYPERTENSION; CARDIOVASCULAR-RESPONSES in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ, Dent Sch, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil; [Blanch, Graziela T.] Pontifical Catholic Univ Goias, Sch Med Pharm & Biomed, Goiania, Go, Brazil in 2020.0, Cited 69.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 mu mol/1 mu l) or ATZ (5 nmol/1 mu l) icv reduced the pressor responses to ANG II (50 ng/1 mu l) icv in SHRs (11 +/- 3 and 17 +/- 4 mmHg, respectively, vs. 35 +/- 6 mmHg) and 2K1C hypertensive rats (3 +/- 1 and 16 +/- 3 mmHg, respectively, vs. 26 +/- 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some scientific research about 61-82-5

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Safari, F; Bayat, M; Nasri, S; Karami, S or concate me.

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-alpha] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process published in 2020.0. Quality Control of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Safari, F (corresponding author), Univ Guilan, Fac Sci, Dept Biol, Rasht, Iran.; Bayat, M (corresponding author), Imam Khomeini Int Univ, Fac Sci, Dept Chem, Qazvin, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products with potential anti-tumor activities. In this study, a new protocol involves three-component condensation of the 3-amino-1,2,4-triazole as a 1,3-binucleophile, versatile aldehydes and Nmethyl-1-(methylthio)-2-nitroethenamine as an enamine analogous in the presence of trichloroacetic acid as a Bronsted-Lowry acidic promoter leads to new functionalized N-alkyl-6-nitro-3,5-dihydro-[1,2,4]triazolo [1,5-a] pyrimidin-7-amine in moderate to good yields. The presence of five nitrogen heteroatoms in the product structure has gathered immense attention among chemists and biologists due to their biological values. Therefore, we evaluated the anti-tumor activity of our synthetic compounds on different cancer cells including human malignant melanoma cells (A375), prostate cancer cells (PC3 cells, LNCaP cells) and normal cells HDF (human dermal fibroblast). Notably, we found that compound 4b that contains a nitro group has the best antitumor activity on three different cancer cells. By using DAPI staining, we showed cancer cells death. Apoptosis induction was shown using quantitative real time PCR (qRT-PCR) by evaluating of Bax and Bcl2 mRNA levels. Finally, we demonstrated that 4b has epithelial-to-mesenchymal transition (EMT) inhibition effect on cancer cells (by induction of E-cadherin and reduction of vimentin mRNA expression levels as two potential EMT markers). So, 4b could be an anti-cancer promising drug. Although, in vivo experiments will be required to evaluate possible side effects.

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Safari, F; Bayat, M; Nasri, S; Karami, S or concate me.

Chemistry Milestones Of 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ma, HF; Li, WB; Ablajan, K or concate me.. Category: Triazoles

An article One-Pot Synthesis of Dihydro[1,2,4]triazolo[1,5-a]pyrimidines and Dihydrobenzo[4,5] imidazo[1,2-a]pyrimidine Derivatives Catalyzed by Amberlyst-15 WOS:000482666500013 published article about SOLVENT-FREE SYNTHESIS; CONVENIENT; TRIAZOLOQUINAZOLINONE; 3-COMPONENT; SYSTEMS in [Ma, Huifang; Li, Wenbo; Ablajan, Keyume] Xinjiang Univ, Coll Chem & Chem Engn, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Urumqi 830046, Peoples R China in 2019.0, Cited 27.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

Under the catalysis of solid acidic ion exchange resin Amberlyst-15, using ethanol as solvent, aromatic aldehyde, beta-ketoester, and 3-amino-1,2,4-triazole or 2-aminobenzo as starting materials, a series of triazolo[1,5-a]pyrimidine derivatives 5a similar to 5m and dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines 6a similar to 6g were synthesized by three-component one-pot reaction of imidazole derivatives. The method is simple and efficient, and has short reaction time, simple post-treatment and wide application range of the substrate. The catalyst can be recycled for 4 times without the significant decrease of catalytic activity. It conforms to the basic standard of green chemistry.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ma, HF; Li, WB; Ablajan, K or concate me.. Category: Triazoles

Archives for Chemistry Experiments of 1H-1,2,4-Triazol-5-amine

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Basirat, N; Sajadikhah, SS; Zare, A or concate me.

I found the field of Chemistry very interesting. Saw the article Ionic liquid-catalyzed synthesis of triazoloquinazolinones, chromeno[4,3-d]benzothiazolopyrimidines and benzoimidazopyrimidine derivatives published in 2020.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Sajadikhah, SS (corresponding author), Payame Noor Univ PNU, Dept Chem, Tehran 193953697, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

1,3-Disulfonic acid imidazolium trifluoroacetate ([Dsim][CF3CO2]) was employed as an efficient, homogeneous and recyclable ionic liquid catalyst for the synthesis of triazoloquinazolinones, chromeno[4,3-d]benzothiazolopyrimidines and benzoimidazopyrimidine derivatives via one-pot multi-component reactions under thermal and solvent-free conditions. The catalyst is demonstrated excellent catalytic properties with good yields in short reaction times and low cost. All products were obtained by recrystallization and there was no need to tedious work-up.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Basirat, N; Sajadikhah, SS; Zare, A or concate me.

The Shocking Revelation of C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Du, XM; Wang, Z; Zhang, HY; Liu, WC; Chen, ZY; Xu, JM or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

Safety of 1H-1,2,4-Triazol-5-amine. In 2019.0 J MEMBRANE SCI published article about POLY(ARYLENE ETHER SULFONE)S; QUATERNARY AMMONIUM GROUPS; FUEL-CELL APPLICATIONS; SIDE-CHAINS; CROSS-LINKING; KETONE); BLOCK; CONDUCTIVITY; ELECTROLYTE; CATIONS in [Du, Xinming; Wang, Zhe; Zhang, Hongyu; Liu, Wenchang; Chen, Zhaoyu; Xu, Jingmei] Changchun Univ Technol, Coll Chem Engn, Changchun 130012, Jilin, Peoples R China; [Du, Xinming; Wang, Zhe; Xu, Jingmei] Changchun Univ Technol, Adv Inst Mat Sci, Changchun 130012, Jilin, Peoples R China in 2019.0, Cited 48.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A double-network anion exchange membrane (TA/AT-PEK/PVA-x) was prepared by Br-PEK and PVA, 3-amino-1,2,4 triazole forms a cross-linking structure with PVA under the action of 1,4-phthalaldehyde and then triazole can be linked with Br-PEK. The structure of membranes was verified by FT-IR. The composite membrane is uniform and smooth can be seen from the scanning electron microscope (SEM) and exhibit good hydrophilic/hydrophobic micro-phase separation structure proved by Transmission electron micrograph (TEM). The ionic conductivity of TA/AT-PEK/PVA-0.15 is 0.062 S/cm at 80 degrees C. With the addition of PVA within a certain range, the water uptake, swelling ratio hydroxide conductivity and alkaline stability are increase. The membranes are more flexible. After immersing in 4M NaOH solutions for 240 h at 80 degrees C, it remains at least 65% of its initial hydroxide ion conductivity of TA/AT-PEK/PVA-0.3 membrane. With the increasing number of water molecules solvating the hydroxide, its nucleophilicity and basicity were hindered, which enhance alkaline stability of anion exchange membranes.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Du, XM; Wang, Z; Zhang, HY; Liu, WC; Chen, ZY; Xu, JM or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

Our Top Choice Compound:C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

Quality Control of 1H-1,2,4-Triazol-5-amine. In 2019.0 ENVIRON MICROBIOL published article about INTERSPECIES ELECTRON-TRANSFER; IV PILI; PROTEIN; REDUCTION; NANOWIRES; EXCHANGE; FE(III) in [Liu, Xing; Zhan, Ji; Jing, Xianyue; Zhou, Shungui] Fujian Agr & Forestry Univ, Coll Resources & Environm, Fujian Prov Key Lab Soil Environm Hlth & Regulat, Fuzhou, Fujian, Peoples R China; [Lovley, Derek R.] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA in 2019.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Mechanisms controlling the expression of the electrically conductive pili (e-pili) of Geobacter species are of interest because of the important role of e-pili in diverse biogeochemical processes, anaerobic digestion and electromicrobiological applications. We investigated the function of the protein, designated Spc (short pilin chaperone), encoded by the gene immediately downstream from the gene for PilA, the monomer that assembles into e-pili. Multiple lines of evidence suggest that Spc forms an oligomer that is associated with the inner membrane. Mutating the start codon of spc to prevent translation increased the transcript abundance of pilA but greatly diminished the abundance of PilA, and e-pili could no longer be detected. Cross-linking, protein capture and two-hybrid studies demonstrated that Spc and PilA interacted. Two sites in PilA for electrostatic interaction with Spc were identified. The results demonstrate that Spc is required for PilA stability prior to incorporation into e-pili, suggesting that Spc has a chaperone function that may be specific to the relatively short PilA monomers that assemble into e-pili. These results are important for identifying microorganisms likely to express e-pili from (meta)genomic data and for the construction of microbial strains expressing e-pili.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

Why do aromatic interactions matter of compound:1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or concate me.. Computed Properties of C2H4N4

An article Bronsted acid-promoted ‘on-water’ C(sp(3))-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction WOS:000510956700009 published article about AZAARENES NUCLEOPHILIC-ADDITION; H BOND FUNCTIONALIZATION; MOLECULAR HYBRIDIZATION; EFFICIENT SYNTHESIS; DESIGN in [Yuan, Shuo; Wang, Sixi; Zhao, Min; Zhang, Danqing; Chen, Jinjie; Li, Jian-Xin; Zhang, Jingya; Song, Yihui; Wang, Jinyi; Yu, Bin; Liu, Hongmin] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Chemical Properties and Facts of 1H-1,2,4-Triazol-5-amine

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Grilo, LF; Martins, JD; Cavallaro, CH; Nathanielsz, PW; Oliveira, PJ; Pereira, SP or concate me.

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 TOXICOL IN VITRO published article about INDUCED OXIDATIVE STRESS; HYDROGEN-PEROXIDE; SUPEROXIDE-DISMUTASE; C-ABL; CELLS; ANTIOXIDANT; EXPRESSION; GENE; DOXORUBICIN; GLUTATHIONE in [Grilo, Luis F.; Martins, Joao D.; Cavallaro, Chiara H.; Oliveira, Paulo J.; Pereira, Susana P.] CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, Cantanhede, Portugal; [Nathanielsz, Peter W.] Coll Agr & Nat Resources, Dept Anim Sci, Laramie, WY USA; [Pereira, Susana P.] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal in 2020.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways involving H2O2. Detoxification and control of H2O2 levels results mainly from catalase activity. The aim of this work was to develop a precise, simple, cost-effective microassay to measure catalase activity in small tissue samples and cell extracts. We developed a protocol that quantifies H2O2 decomposition by intrinsic catalase in biological samples. Catalase activity was calculated based on rate of decomposition of H2O2, following absorbance at 240 nm. We developed a multi-well spectroscopic approach, reducing sample quantity requirements and allowing simultaneous assessment of large number of samples. The protocol is sensitive across a wide range of catalase activity (11.5-7575 U). The assay presents a 95% confidence interval with an intra-assay coefficient of variation of 3.7%, an inter-assay coefficient of variation of 6.2% and good correlation with a commercial kit. The assay was established and validated for different biological samples, including sheep hepatic tissue and human tumor and non-tumor cell lines. This high-throughput method is robust, sensitive, time-saving and cost-effective, generating highly reproducible results with precision and good correlation with a commercial kit reinforcing the method’s validity for research and toxicological applications.

Downstream Synthetic Route Of C2H4N4

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mei, J; Liu, WF; Huang, JH; Qiu, XQ or concate me.

An article Lignin-Reinforced Ethylene-Propylene-Diene Copolymer Elastomer via Hydrogen Bonding Interactions WOS:000464437200017 published article about CROSS-LINKING; RUBBER; EXTRACTION in [Mei, Jie; Liu, Weifeng; Huang, Jinhao; Qiu, Xueqing] South China Univ Technol, Sch Chem & Chem Engn, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China; [Qiu, Xueqing] South China Univ Technol, State Key Lab Pulp & Paper Engn, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China in 2019.0, Cited 27.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

It is still a great challenge to prepare lignin/polyolefin composites with good strength and toughness. Inspired by the energy sacrificial mechanism from biomaterials, dynamic hydrogen bonds (H-bonds) are incorporated into the lignin/ethylene-propylene-diene monomer (EPDM) composite system to improve the interfacial interactions between lignin and EPDM. Such H-bonding interactions are demonstrated to be able to simultaneously improve the modulus, strength, and toughness of lignin/EPDM composites without sacrificing the extensibility. This work provides a facile method for the high-valued utilization of lignin in the preparation of high-performance elastomer composites using bio-renewable resources as reinforcing agent.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mei, J; Liu, WF; Huang, JH; Qiu, XQ or concate me.

You Should Know Something about 1H-1,2,4-Triazol-5-amine

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Drokin, RA; Tiufiakov, DV; Voinkov, EK; Slepukhin, PA; Ulomsky, EN; Esaulkova, YL; Volobueva, AS; Lantseva, KS; Misyurina, MA; Zarubaev, VV; Rusinov, VL or concate me.

In 2021.0 CHEM HETEROCYCL COM+ published article about ETIOTROPIC THERAPY; INFLUENZA; PRECURSOR; ARVI in [Drokin, Roman A.; Tiufiakov, Dmitrii V.; Voinkov, Egor K.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia; [Slepukhin, Pavel A.; Ulomsky, Evgeny N.; Rusinov, Vladimir L.] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, 22-20 Sofyi Kovalevskoi St, Ekaterinburg 620108, Russia; [Esaulkova, Yana L.; Volobueva, Alexandrina S.; Misyurina, Mariya A.; Zarubaev, Vladimir V.] St Petersburg Pasteur Res Inst Epidemiol & Microb, 14 Mira St, St Petersburg 197101, Russia; [Lantseva, Kristina S.] St Petersburg State Univ, 7-9 Univ Embankment, St Petersburg 199034, Russia in 2021.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

An azo coupling reaction of alpha-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-c][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.