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How did you first get involved in researching 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, J; Wu, WJ; Liang, JH; Jin, YJ; Gazzarrini, S; He, JN; Yi, MF or concate me.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. In 2019.0 PLANT CELL PHYSIOL published article about ABSCISIC-ACID; SEED-GERMINATION; CELL-DIVISION; GENE-EXPRESSION; POTATO-TUBERS; CLASS-I; ARABIDOPSIS; CYTOKININ; GROWTH; BIOSYNTHESIS in [Wu, Jian; Wu, Wenjing; Liang, Jiahui; Jin, Yujie; He, Junna; Yi, Mingfang] China Agr Univ, Dept Ornamental Hort & Landscape Architecture, Beijing Key Lab Dev & Qual Control Ornamental Cro, Beijing 100193, Peoples R China; [Wu, Jian; Gazzarrini, Sonia] Univ Toronto Scarborough, Dept Biol Sci, Toronto, ON, Canada; [Gazzarrini, Sonia] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada in 2019.0, Cited 55.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Dormancy is one of the least understood phenomena in plant biology; however, bud/corm dormancy is an important economic trait in agricultural/horticultural breeding. In this study, we isolated an ABA biosynthesis gene, GhNCED, from the transcriptome database of corm dormancy release (CDR), and characterized its negative role in regulating CDR. To understand transcriptional regulation of GhNCED, yeast one-hybrid screening was conducted and GhTCP19 was identified and shown to regulate GhNCED expression directly. An in planta assay showed that GhTCP19 negatively regulates GhNCED expression. GhTCP19 is dramatically induced by exogenous cytokinins (CKs) and is induced during CDR. Silencing of GhTCP19 in dormant cormels delayed CDR, resulting in higher expression of GhNCED and ABA levels. Meanwhile, endogenous CK biosynthesis and signaling were inhibited in GhTCP19-silenced cormels. Taken together, our results reveal that GhTCP19 is a positive regulator of the CDR process by repressing expression of an ABA biosynthesis gene (GhNCED), promoting CK biosynthesis (GhIPT) and signal transduction (GhARR) as well as inducing cyclin genes. This study expands our knowledge on CDR which is mediated by TCP family members.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

What I Wish Everyone Knew About 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT or concate me.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Recently I am researching about PHENOLIC SCHIFF-BASES; NMR CHEMICAL-SHIFTS; TRIAZOLOPYRIMIDINE; MECHANISM; APPROXIMATION; INHIBITORS; COMPLEXES; HERBICIDE; POTENT; SAR, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Two new (4-5) and a known (3) derivatives of 1,2,4-triazolo [1,5-a]pyrimidine are synthesized and characterized through spectroscopic NMR, FT-IR and single crystal X-ray diffraction techniques. Along with experimental data, the predicted spectral data are obtained using density functional theory (DFT) at the B3LYP/6-31 + G (d,p) level of theory. The closest contacts between active atoms of the compounds are identified through Hirshfeld surface analysis and electrostatic potential map (EPM) studies. Relatively, good correlations were found between the experimental and predicted spectroscopic data with correlation coefficients higher than 90%. Hirshfeld surface analysis and EPM reveal that the closest interaction between the units of the compounds are between hydrogen atoms (39.6-46.3%). The antioxidant activity of 3-5 is evaluated using DPPH free radical scavenging and ferric reducing antioxidant power assays. (C) 2018 Elsevier B.V. All rights reserved.

The Best Chemistry compound:1H-1,2,4-Triazol-5-amine

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.

HPLC of Formula: C2H4N4. In 2019.0 ENVIRON MICROBIOL published article about INTERSPECIES ELECTRON-TRANSFER; IV PILI; PROTEIN; REDUCTION; NANOWIRES; EXCHANGE; FE(III) in [Liu, Xing; Zhan, Ji; Jing, Xianyue; Zhou, Shungui] Fujian Agr & Forestry Univ, Coll Resources & Environm, Fujian Prov Key Lab Soil Environm Hlth & Regulat, Fuzhou, Fujian, Peoples R China; [Lovley, Derek R.] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA in 2019.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Mechanisms controlling the expression of the electrically conductive pili (e-pili) of Geobacter species are of interest because of the important role of e-pili in diverse biogeochemical processes, anaerobic digestion and electromicrobiological applications. We investigated the function of the protein, designated Spc (short pilin chaperone), encoded by the gene immediately downstream from the gene for PilA, the monomer that assembles into e-pili. Multiple lines of evidence suggest that Spc forms an oligomer that is associated with the inner membrane. Mutating the start codon of spc to prevent translation increased the transcript abundance of pilA but greatly diminished the abundance of PilA, and e-pili could no longer be detected. Cross-linking, protein capture and two-hybrid studies demonstrated that Spc and PilA interacted. Two sites in PilA for electrostatic interaction with Spc were identified. The results demonstrate that Spc is required for PilA stability prior to incorporation into e-pili, suggesting that Spc has a chaperone function that may be specific to the relatively short PilA monomers that assemble into e-pili. These results are important for identifying microorganisms likely to express e-pili from (meta)genomic data and for the construction of microbial strains expressing e-pili.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.

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Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or concate me.

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Liang, L; Ye, M (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7. Chemical structures of the new compounds were elucidated by NMR and MS analyses. Furthermore, cytotoxicities of the triterpenoid derivatives were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7). As a result, 1a, 1g, and 4a exhibited potent cytotoxic activities against HL60, U251, and SW480 with IC50 values of 0.7 +/- 0.9, 2.9 +/- 1.3, and 2.2 +/- 0.6 mu M, respectively. Molecular docking indicates that 1a, 1g, and 4a have strong binding affinity with DNA topoisomerase II alpha (-9.3, -7.9, and -7.4 kcal/mol, respectively), and that they could be potent topoisomerase II alpha inhibitors.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or concate me.

Machine Learning in Chemistry about 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Chen, S; Wang, YT; An, ZH; Ma, M; Shi, YQ; Wang, X or concate me.. Category: Triazoles

I found the field of Thermodynamics; Chemistry very interesting. Saw the article Stability, antibacterial ability, and inhibition of zinc burning of amitrole as thermal stabilizer for transparent poly(vinyl chloride) published in 2019.0. Category: Triazoles, Reprint Addresses Wang, X (corresponding author), Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Amitrole is reported as a novel kind of transparent poly(vinyl chloride) (PVC) thermal stabilizer that has both excellent inhibition of zinc burning thermal stability and antibacterial ability in this paper, which provide the possibility of applying the whole PVC industry into medical and food packaging, artificial leather, wire and cable, indoor decoration, and so on. From the results of Congo red test, discoloration test, and dynamic thermal stability test, we could clearly find out that amitrole could effectively replace the unstable chlorine atom and inhibit zinc burning of transparent PVC, while the long-term stability should be improved. Next, the stabilization mechanism of amitrole was also confirmed. The antibacterial activity of amitrole was measured by the bacteriostatic ring experiments. It was observed that the PVC films had good antibacterial properties after modified by amitrole. At last, optimal design of the amitrole/ZnSt(2) (1:1)/ESBO formulation was studied, which have strong potential as thermal stabilizer to prepare super transparency and antibacterial PVC resin.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Chen, S; Wang, YT; An, ZH; Ma, M; Shi, YQ; Wang, X or concate me.. Category: Triazoles

Extracurricular laboratory: Synthetic route of 1H-1,2,4-Triazol-5-amine

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N or concate me.

Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N in [Umar, Tarana; Hoda, Nasimul] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Shalini, Shruti; Gusain, Siddharth; Seth, Prerna; Tiwari, Manisha] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, New Delhi 110007, India; [Raza, Md Kausar] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India; [Kumar, Jitendra] Sardar Vallabhbhai Patel Coll, Dept Chem, Bhabua 821101, Kaimur, India; [Kumar, Jitendra] VKSU, Ara 802301, Bihar, India published A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease in 2019.0, Cited 65.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

2-(piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid beta aggregation inhibitors. Formation of synthesized compounds (P1-P9) was justified via H-1 NMR, C-13 NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated A beta aggregation and Cu(II)-mediated A beta aggregation. Also, docking study carried out was in concordance with in vitro results. The most potent molecule amongst the derivatives exhibited excellent anti-AChE activity (IC50=4.8 nM). Kinetic study of P3 suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds are capable of inhibiting self-induced beta-amyloid (A beta) aggregation with the highest inhibition percentage to be 81.65%. Potency of P1 and P3 to inhibit self-induced A beta(1-)(42) aggregation was ascertained by TEM analysis. Compounds were also evaluated for their A beta disaggregation, antioxidation, metal-chelation activity. (C) 2019 Elsevier Masson SAS. All rights reserved.

New explortion of 61-82-5

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Fandzloch, M; Augustyniak, AW; Dobrzanska, L; Jedrzejewski, T; Sitkowski, J; Wypij, M; Golinska, P or concate me.

Fandzloch, M; Augustyniak, AW; Dobrzanska, L; Jedrzejewski, T; Sitkowski, J; Wypij, M; Golinska, P in [Fandzloch, Marzena] PAS, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Augustyniak, Adam W.] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland; [Dobrzanska, Liliana] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, Lwowska 1, PL-87100 Torun, Poland; [Sitkowski, Jerzy] Natl Inst Med, Chelmska 30-34, PL-00725 Warsaw, Poland; [Sitkowski, Jerzy] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Wypij, Magdalena; Golinska, Patrycja] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Microbiol, Lwowska 1, PL-87100 Torun, Poland published First dinuclear rhodium(II) complexes with triazolopyrimidines and the of their use in 2020.0, Cited 82.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Five novel rhodium(II) complexes of general formula [Rh-2(mu-OOCCH3)(4)L-2], where L is a triazolopyrimidine derivative, in particular dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) for (1), 5,7-diethyl-1,2,4-triazolo[1,5a]pyrimidine (detp) for (2), 7-isobutyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) for (3), 7-hydroxy-5methyl-1,2,4-triazolo[1,5-a]pyrimidine (HmtpO) for (4) and 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) for (5) are reported. These first representatives of paddle-wheel dirhodium complexes with triazolopyrimidines have been characterized by IR and NMR spectroscopy as well as by single-crystal X-ray diffraction studies. Three of the new complexes (1), (2) and (5) were thoroughly screened in vitro for their cytotoxicity against human breast cancer cell line MCF-7 and L929 murine fibroblast cells. Favorably, they show significantly less effective inhibition on the cell growth of L929 than cisplatin under identical conditions. Complexes (1) and (5) display moderate cytotoxic activity (IC50 = 16.3-21.5 mu M) against MCF-7 cells which is induced via reactive oxygen species-independent pathways. Extensive studies of rhodium complexes (1), (2) and (5) against microorganisms have shown that the tested compounds exhibit antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) while (5) significantly inhibited the growth of Malassezia furfur. The highest antibacterial, and antifungal activity, was observed for (5).

How did you first get involved in researching C2H4N4

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Qu, L; Li, HL; Guo, D; Wang, Y; Zhu, JH; Yin, LY; Peng, SQ or concate me.

An article HbWRKY27, a group IIe WRKY transcription factor, positively regulates HbFPS1 expression in Hevea brasiliensis WOS:000596327900012 published article about FARNESYL DIPHOSPHATE SYNTHASE; ZINC-FINGER PROTEIN; ISOPRENOID BIOSYNTHESIS; MOLECULAR CHARACTERIZATION; MEVALONATE PATHWAY; IN-VITRO; GENE; CLONING; PLANT; EVOLUTION in [Qu, Long; Yin, Li-Yan] Hainan Univ, Sch Life & Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China; [Qu, Long; Li, Hui-Liang; Guo, Dong; Wang, Ying; Zhu, Jia-Hong; Peng, Shi-Qing] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China in 2020.0, Cited 46.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Farnesyl pyrophosphate synthase (FPS) is a key enzyme that catalyzes the formation of farnesyl pyrophosphate, the main initiator for rubber chain initiation in Hevea brasiliensis Muell. Arg. The transcriptional regulatory mechanisms of the FPS gene still not well understood. Here, a WRKY transcription factor designated HbWRKY27 was obtained by screening the latex cDNA library applied the HbFPS1 promoter as bait. HbWRKY27 interacted with the HbFPS1 promoter was further identified by individual Y1H and EMSA assays. HbWRKY27 belongs to group IIe WRKY subfamily which contains a typical WRKY domain and C-X5-CX23-HXH motif. HbWRKY27 was localized to the nucleus. HbWRKY27 predominantly accumulated in latex. HbWRKY27 was up-regulated in latex by ethrel, salicylic acid, abscisic acid, and methyl jasmonate treatment. Transient expression of HbWRKY27 led to increasing the activity of the HbFPS1 promoter in tobacco plant, suggesting that HbWRKY27 positively regulates the HbFPS1 expression. Taken together, an upstream transcription factor of the key natural rubber biosynthesis gene HbFPS1 was identified and this study will provide novel transcriptional regulatory mechanisms of the FPS gene in Hevea brasiliensis.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Qu, L; Li, HL; Guo, D; Wang, Y; Zhu, JH; Yin, LY; Peng, SQ or concate me.

Chemical Research in C2H4N4

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Iqbal, U; Choudhary, MI; Yousuf, S or concate me.

I found the field of Chemistry very interesting. Saw the article Synthesis of co-crystals of anti-cancer nandrolone as a potential leads towards treatment of cancer published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Yousuf, S (corresponding author), Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Sindh, Pakistan.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Co-crystals are emerging as members of supramolecular family having particular practical and fundamental significance for chemists, crystallographers, pharmaceutical scientists, and theoreticians. The presented study is focused to synthesize anti-cancer co-crystals of commercially available nandrolone (1), a synthetic anabolic-androgenic steroidal drug. Co-crystallization is done using economical and green grinding and reflux methods to obtain nandrolone (Nan): salicylic acid (Sal) and nandrolone (Nan): 3-amino-1,2,4-triazole (Triz) co-crystals, in 2:1 and 1:1 stoichiometric ratios, respectively. The structural analysis and characterization were carried out using single-crystal X-ray diffraction, and vibrational spectroscopy. Nandrolone (1) crystallizes in monoclinic P2(1) space group, while the co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz), co-crystallized in the orthorhombic P2(1)2(1)2(1) space group. The intermolecular hydrogen bonds O-H center dot center dot center dot O, C-H center dot center dot center dot O, N-H center dot center dot center dot O, O-H center dot center dot center dot N, and N-H center dot center dot center dot N between the active pharmaceutical ingredient (nandrolone) and co-formers (salicylic acid, and 3-amino-1,2,4-triazole) stabilize the structures of cocrystals. In vibrational spectroscopy of co-crystal-I (Nan:Sal), the blue shifts in stretching frequencies of hydroxyl group from 3417.9 cm(-1) to 3427.8 cm(-1) further supported the hydrogen bond interactions between API and co-former. Similarly, in co-crystal-II (Nan:Triz) the NH2 stretching frequency from 3331.4- 3413.4 cm(-1) to 3312.7 cm(-1), supported the interaction of NH2 with API via intermolecular interaction. Nandrolone (1) and both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Nandrolone (IC50 = 1.0 0.1 mu M), co-crystal-I (Nan:Sal) (IC50 = 1.6 +/- 0.3 mu M) and-II (Nan:Triz) (IC50 = 1.8 +/- 0.1 mu M) showed anti-cancer potential against cervical cancer HeLa cell line. While doxorubicin (IC50 = 1.2 +/- 0.2 mu M) was used as standard tested compound. SYNOPSIS Two new non-cytotoxic co-crystals of synthetic anabolic-androgenic steroidal drug nandrolone (Nan) with pharmaceutically acceptable salicylic acid (Sal), and triazole (Triz) were synthesized and their structures were elucidated using single-crystal X-ray diffraction, and vibrational spectroscopy. Quantitative analysis of -OH and -NH2 intermolecular interactions between API and co-former by Hirshfeld surface analysis further supported the role of various functionalities towards the stability of co-crystals. Both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz) were found to be selectively active against HeLa cancer cell line (IC50 = 1.6 +/- 0.3 mu M), (IC50 = 1.8 +/- 0.1 mu M). (c) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Iqbal, U; Choudhary, MI; Yousuf, S or concate me.

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Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT or concate me.

Safety of 1H-1,2,4-Triazol-5-amine. Authors Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT in INT UNION CRYSTALLOGRAPHY published article about in [Ben Ali, Abdelkader] Mohammed V Univ Rabat, Fac Sci, Ctr Sci Mat, Lab Chim Appl Mat, Ave Ibn,BP 1014, Rabat, Morocco; [El Bakri, Youness; Sebhaoui, Jihad; El Ghayati, Lhoussaine; Essassi, El Mokhtar] Univ Mohammed 5, Fac Sci, Ctr Rech Sci Med, URAC 21,Pole Competence Pharmacochim, Av Ibn Battouta,BP 1014, Rabat, Morocco; [Lai, Chin-Hung] Chung Shan Med Univ, Dept Med Appl Chem, Taichung 40241, Taiwan; [Lai, Chin-Hung] Chung Shan Med Univ Hosp, Dept Med Educ, Taichung 40241, Taiwan; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA in 2019.0, Cited 38.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In the title molecule, C13H16N4O3, the mean planes of the phenyl and triazole rings are nearly perpendicular to one another as a result of the intramolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi(ring) interactions. In the crystal, layers parallel to (101) are generated by O-H center dot center dot center dot N, N-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen bonds. The layers are connected by inversion-related pairs of C-H center dot center dot center dot O hydrogen bonds. The experimental molecular structure is close to the gas-phase geometryoptimized structure calculated by DFT methods. Hirshfeld surface analysis indicates that the most important interaction involving hydrogen in the title compound is the H center dot center dot center dot H contact. The contribution of the H center dot center dot center dot O, H center dot center dot center dot N, and H center dot center dot center dot H contacts are 13.6, 16.1, and 54.6%, respectively.