You Should Know Something about 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Alimoradi, S; Stohr, H; Stagg-Williams, S; Sturm, B or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

An article Effect of temperature on toxicity and biodegradability of dissolved organic nitrogen formed during hydrothermal liquefaction of biomass WOS:000497885800016 published article about MICROALGAE CULTIVATION; MAILLARD REACTION; AQUEOUS-PHASE; HILL EQUATION; FATTY-ACIDS; ALGAE; WASTE; OIL; INHIBITION; CONVERSION in [Alimoradi, Sirwan; Sturm, Belinda] Univ Kansas, Civil Environm & Architectural Engn Dept, Lawrence, KS 66045 USA; [Stohr, Hannah; Stagg-Williams, Susan] Univ Kansas, Chem & Petr Engn Dept, Lawrence, KS 66045 USA in 2020.0, Cited 42.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

This study investigated the nutrient content and reuse potential of wastewater generated during hydrothermal liquefaction of microalgal biomass. The hydrothermal liquefaction reaction was tested at 270, 300, 330, and 345 degrees C to determine the effect of temperature on the formation of non-biodegradable dissolved organic nitrogen (nbDON). Total nitrogen, ammonium, color, and toxicity were selected as key characteristics for the reuse of hydrothermal liquefaction wastewater. Results indicated that a higher concentration of nbDON(5) (nbDON defined with a 5 day growth assay) and more diverse heterocyclic N-containing organic compounds were associated with greater toxicity as measured by a growth rate assay. For the tested temperature ranges, the total nitrogen content of the hydrothermal liquefaction wastewater slightly decreased from 5020 +/- 690 mg L-1 to 4160 +/- 120 mg L-1, but the % nbDON(5) fraction increased from 57 +/- 3 %DON to 96 +/- 5 %DON. The temperature of hydrothermal liquefaction reactions can be optimized to maximize carbon conversion and nitrogen recovery. (C) 2019 Elsevier Ltd. All rights reserved.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Alimoradi, S; Stohr, H; Stagg-Williams, S; Sturm, B or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Never Underestimate The Influence Of 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ding, JL; Lin, HY; Feng, MG; Ying, SH or concate me.. SDS of cas: 61-82-5

An article Mbp1, a component of the MluI cell cycle box-binding complex, contributes to morphological transition and virulence in the filamentous entomopathogenic fungus Beauveria bassiana WOS:000499789500001 published article about IN-VITRO; TRANSCRIPTION; PROTEIN; SURFACE; GENE; DIFFERENTIATION; GROWTH; ROLES; PATHOGENESIS; CONIDIATION in [Ding, Jin-Li; Lin, Hai-Yan; Feng, Ming-Guang; Ying, Sheng-Hua] Zhejiang Univ, Coll Life Sci, Inst Microbiol, Hangzhou 310058, Zhejiang, Peoples R China in 2020.0, Cited 50.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

The Mbp1 protein functions as a DNA-binding protein in the MluI cell cycle box-binding complex and plays significant roles in yeast development. In this study, an ortholog of yeast Mbp1, BbMbp1, was characterized in a filamentous insect mycopathogen, Beauveria bassiana. BbMbp1 plays an important role in morphological changes under aerial and liquid environments. On the aerial surface, BbMbp1 was indispensable for the biogenesis of conidiophores and conidiation. Under submerged conditions, the increment BbMbp1 mutant displayed abnormal spore-producing structures, with a dramatic decrease in blastospore yield (similar to 95%). The virulence of the increment BbMbp1 mutant was notably weakened, which might be due to the defect in in vivo blastospore formation in the insect. Moreover, disruption of BbMbp1 resulted in a substantial reduction in hyphal growth on cadavers. Comparative transcriptomics revealed that BbMbp1 mediated different transcriptomes during the formation processes of conidia and blastospores. Yeast one-hybrid assays demonstrated that BbMbp1 was required for transcriptional control of a cell wall protein gene, BbCwp, and an integral membrane protein gene, BbImp that played significant roles in conidiation and blastospore formation respectively. Our results demonstrate that BbMbp1 contributes to the morphological transitions in the pathogenic and saprophytic growth of B. bassiana via different genetic pathways.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ding, JL; Lin, HY; Feng, MG; Ying, SH or concate me.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Awesome and Easy Science Experiments about 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zubir, M; Nasutioni, HI; Sudarma, TF or concate me.. HPLC of Formula: C2H4N4

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article The Role of Micropores and Amino Groups in Preferential CO2 Adsorptivity of Porous Zn-Coordination Polymers Comprising Mixed Ligands of Triazole and Amino Triazole published in 2019.0. HPLC of Formula: C2H4N4, Reprint Addresses Zubir, M (corresponding author), State Univ Medan, Fac Math & Nat Sci, Chem Dept, Jl Willem Iskandar,Pasar 5,Medan Estate, Medan 20221, North Sumatera, Indonesia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Porous coordination polymers (PCPs) of Zn2+, oxalic acid and mixture ratio of 3-amino, 1,2,4-triazole (Ataz) and 1,2,4-triazole (Taz) were synthesized to capture of carbon dioxide. A series of molar fraction Taz/(Taz + ATaz) prepared as 0.1;0.3;0.4;0.5;0.6;0.7 and 0.9 and also only ATaz and Taz ligand as 0 and 1 molar fraction respectively. Mixture of Taz and ATaz crystal induce new structure of 0.4, 0.5 and 0.6 molar fraction. Nitrogen adsorption of 50% mixture each ligand contribute the highest surface area as function of optimum condition to integrate pore space and amine group presence with adsorbed as 290 mgg(-1). This phenomena also shown through CO2 adsorption amount as 135 mgg(-1), instead of 0.4, 0.6 and 0.7 molar fraction observed higher amount of CO2 compared with only Taz ligand (X=1), indicate the integrated effects both of the ligand could generated the capture of higher amount of carbon dioxide.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zubir, M; Nasutioni, HI; Sudarma, TF or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

You Should Know Something about 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact McCune, F; Samson-Robert, O; Rondeau, S; Chagnon, M; Fournier, V or concate me.. COA of Formula: C2H4N4

COA of Formula: C2H4N4. In 2021.0 ENVIRON SCI POLLUT R published article about APIS-MELLIFERA; NEONICOTINOID INSECTICIDES; ENVIRONMENTAL RISKS; WARDECKER WATERERS; WATERING DEVICE; SURFACE WATERS; HYMENOPTERA; RESIDUES; WORKERS; APIDAE in [McCune, Frederic; Samson-Robert, Olivier; Rondeau, Sabrina; Fournier, Valerie] Univ Laval, Ctr Rech & Innovat Vegetaux, Quebec City, PQ G1V 0A6, Canada; [Rondeau, Sabrina] Univ Guelph, Sch Environm Sci, Guelph, ON N1G 2W1, Canada; [Chagnon, Madeleine] Univ Quebec Montreal, Dept Sci Biol, Montreal, PQ H3C 3P8, Canada in 2021.0, Cited 104.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Water is essential for honey bees (Apis mellifera L.), but contaminated sources of water in agricultural environments represent a risk of exposure to potentially harmful contaminants. Providing clean water to honey bees could be an efficient and cost-effective measure for beekeepers to reduce bee mortality associated with pesticides and improve the health of their colonies. The main goal of this study was to design a waterer prototype to fulfill the water requirements of honey bees and to evaluate the potential of this waterer in improving colonies’ health in agricultural settings, through mitigating the possible impact of an exposure to pesticides from puddle water. We tested the preference of honey bees regarding water composition and waterer prototypes, among which honey bees showed a strong preference for salted water and a poultry-type waterer. Our waterer models were quickly adopted and intensively used through the season in both the context of honey production in field crops and pollination services in cranberry crops. However, in neither context did the use of waterers reduce worker mortality nor increase overall colony weight. Our waterers provided bees with water containing fewer pesticides and were associated with reduced risks of drowning compared to natural sources of water. Our study suggests that the use of waterers fulfills an important requirement for honey bees and represents an interesting and convenient precautionary measure for beekeepers.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact McCune, F; Samson-Robert, O; Rondeau, S; Chagnon, M; Fournier, V or concate me.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Get Up to Speed Quickly on Emerging Topics:61-82-5

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

I found the field of Biochemistry & Molecular Biology very interesting. Saw the article Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins published in 2019.0. Computed Properties of C2H4N4, Reprint Addresses Kapoor, TM (corresponding author), Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Search for chemical structures by a sketch :1H-1,2,4-Triazol-5-amine

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT or concate me.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT in [Lahmidi, Sanae; El Hafi, Mohamed; Boulhaoua, Mohammed; Essassi, El Mokhtar] Mohammed V Univ Rabat, Ctr Rech Sci Med, Pole Competences Pharmacochim, Lab Chim Organ Heterocycl,Fac Sci,URAC 21, Ave Ibn Battouta,BP 1014, Rabat, Morocco; [Anouar, El Hassane] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities, Dept Chem, BP 830, Al Kharj, Saudi Arabia; [Ejjoummany, Abdelaziz] Univ Hassan II Casablanca, EST Mohammedia, Lab Chim Phys & Chim Bioorgan, BP 146, Mohammadia 28800, Morocco; [El Jemli, Meryem] Mohammed V Univ, Fac Med & Pharm, Lab Pharmacol & Toxicol, Pharmacodynamy Res Team,ERP,Rabat Inst, BP 6203, Rabat, Morocco; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA published Synthesis, X-ray, spectroscopic characterization, DFT and antioxidant activity of 1,2,4-triazolo[1,5-a]pyrimidine derivatives in 2019.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Two new (4-5) and a known (3) derivatives of 1,2,4-triazolo [1,5-a]pyrimidine are synthesized and characterized through spectroscopic NMR, FT-IR and single crystal X-ray diffraction techniques. Along with experimental data, the predicted spectral data are obtained using density functional theory (DFT) at the B3LYP/6-31 + G (d,p) level of theory. The closest contacts between active atoms of the compounds are identified through Hirshfeld surface analysis and electrostatic potential map (EPM) studies. Relatively, good correlations were found between the experimental and predicted spectroscopic data with correlation coefficients higher than 90%. Hirshfeld surface analysis and EPM reveal that the closest interaction between the units of the compounds are between hydrogen atoms (39.6-46.3%). The antioxidant activity of 3-5 is evaluated using DPPH free radical scavenging and ferric reducing antioxidant power assays. (C) 2018 Elsevier B.V. All rights reserved.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lahmidi, S; Anouar, EH; El Hafi, M; Boulhaoua, M; Ejjoummany, A; El Jemli, M; Essassi, EM; Mague, JT or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Now Is The Time For You To Know The Truth About 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kassem, AF; Abbas, EMH; Al-Qurashi, NT; Farghaly, TA or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

An article New azoloazine derivatives as antimicrobial agents: Synthesis under microwave irradiations, structure elucidation, and antimicrobial activity WOS:000503541800001 published article about ONE-POT SYNTHESIS; ASSISTED SYNTHESIS; REARRANGEMENT; HETEROCYCLES in [Kassem, Asmaa F.; Abbas, Eman M. H.] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Chem Nat & Microbial Prod Dept, 33 Bohouth St,POB 12622, Giza, Egypt; [Al-Qurashi, Nadia T.] Umm Al Qura Univ, Univ Coll Adam, Dept Basic Sci, Mecca, Almukkarramah, Saudi Arabia; [Farghaly, Thoraya A.] Cairo Univ, Fac Sci, Dept Chem, Giza 1263, Egypt; [Farghaly, Thoraya A.] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca 21514, Almukkarramah, Saudi Arabia in 2020.0, Cited 28.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

With aiding of microwave radiation, new series of fused-thiazolopyrimidines and fused-triazolopyrimidines each with cycloheptane have been synthesized through the reaction of cycloheptane-thione with alpha-haloketones or hydrazonoyl chlorides in short-time intervals as well as high yield. Moreover, reaction of 2,7-bis(2-chlorobenzylidene)cycloheptan-1-one with o-aminothiophenol and heterocyclic amines afforded benzo[b]cyclohepta[e][1,4]thiazepine derivative and cycloheptapyrimidines fused with different azoles, respectively. The structure for all products was discussed and proved based on the results of spectral data and elemental analysis. Evaluation of the antimicrobial activity of selected products indicated that most of derivatives showed their potent activity exceeds the reference antibiotic in some cases.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kassem, AF; Abbas, EMH; Al-Qurashi, NT; Farghaly, TA or concate me.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Let`s talk about compound :61-82-5

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Malode, SJ; Prabhu, KK; Shetti, NP or concate me.

I found the field of Chemistry very interesting. Saw the article Electrocatalytic behavior of a heterostructured nanocomposite sensor for aminotriazole published in 2020.0. Formula: C2H4N4, Reprint Addresses Malode, SJ; Shetti, NP (corresponding author), KLE Inst Technol, Ctr Electrochem Sci & Mat, Dept Engn Chem, Hubballi 580027, Karnataka, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Aminotriazole (AT), an organic heterocyclic compound, is an unselective herbicide used to deal with a large assortment of weeds by preventing the biosynthesis of carotenoids. It is a malignant agent to human beings as well as to animals. This study is focused on the nanomolar detection of AT with multiwalled carbon nanotubes along with calcium-doped zinc oxide nanoparticles adapted for a nano-composite dependent glassy carbon electrode (MWCNTs/Ca-ZnO/GCE). The developed MWCNTs/Ca-ZnO/GCE showed an excellent electrocatalytic response to AT in 3.0 pH of 0.2 M phosphate buffer solution (PBS). There was an increase in the peak current of AT, i.e., 7.726 mu A, with MWCNTs/Ca-ZnO/GCE when it was compared with the peak current of AT at the bare glassy carbon electrode (GCE), 3.478 mu A, due to the semiconducting properties of the doped nanoparticles. Various techniques were employed to study the different parameters such as scan rate, pH variations, and concentration variations by cyclic voltammetry (CV), square wave voltammetry (SWV), and linear sweep voltammetry (LSV) in order to probe the mechanism, number of participating electrons, type of process, detection limit, and quantification limit. The Ca-ZnO nanoparticles (NPs) were synthesized at the proportion of 5.0% and these were characterized by energy dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The developed sensor was applied for real sample analysis like soil and water by quantifying the AT in the samples and the output was found to be precise with good recovery results.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Malode, SJ; Prabhu, KK; Shetti, NP or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Something interesting about 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN or concate me.. Name: 1H-1,2,4-Triazol-5-amine

An article Development of a Multiresidue Method for Endocrine-Disrupting Pesticides by Solid Phase Extraction and Determination by UHPLC-MS/MS from Drinking Water Samples WOS:000537475500002 published article about TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN HEALTH-RISK; ORGANOCHLORINE PESTICIDES; TRACE DETERMINATION; POLAR PESTICIDES; HPLC-DAD; PHARMACEUTICALS; RIVER; SPE in [Liu, Shaoying; Huang, Xihui; Hu, Kejun; Jin, Quan] Hangzhou Ctr Dis Control & Prevent, Lab Chem & Phys, Hangzhou, Peoples R China; [Zhu, Guonian] Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou, Peoples R China in 2020.0, Cited 44.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A rapid and efficient method based on solid phase extraction and liquid chromatography-tandem mass spectrometry was validated, allowing the determination of the endocrine-disrupting herbicides (acetochlor, alachlor, amitrole and atrazine), fungicides (carbendazim, triadimefon, penconazole and propiconazole), and insecticides (carbaryl and carbofuran) in drinking water. Low method detection limits (0.01-0.64 ng/L) and method quantification limits (0.03-2.13 ng/L) were obtained with satisfactory recoveries and precision for the endocrine-disrupting pesticides. The method was applied for real drinking water samples collected in the area of the city of Hangzhou (Zhejiang, China); the results showed that carbendazim, atrazine and acetochlor were detected in the drinking water samples and acetochlor was the most detected analyte.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN or concate me.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

More research is needed about 1H-1,2,4-Triazol-5-amine

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

I found the field of Biochemistry & Molecular Biology very interesting. Saw the article Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins published in 2019.0. Product Details of 61-82-5, Reprint Addresses Kapoor, TM (corresponding author), Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics