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Search for chemical structures by a sketch :1H-1,2,4-Triazol-5-amine

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Suzuki, S; Hasegawa, A; Uebori, M; Shinomiya, M; Yoshida, Y; Ookubo, K; Takino, M; Hasegawa, H; Takazawa, M; Takemine, S or concate me.

Safety of 1H-1,2,4-Triazol-5-amine. Authors Suzuki, S; Hasegawa, A; Uebori, M; Shinomiya, M; Yoshida, Y; Ookubo, K; Takino, M; Hasegawa, H; Takazawa, M; Takemine, S in WILEY published article about in [Suzuki, Shigeru; Uebori, Michiko; Takazawa, Mari] Chubu Univ, Grad Sch Biosci & Biotechnol, 1200 Matsumoto, Kasugai, Aichi 4878501, Japan; [Hasegawa, Atsuko] Kanagawa Environm Res Ctr, Environm Conservat Div, 1-3-39,Shinomiya, Hiratsuka, Kanagawa 2540014, Japan; [Shinomiya, Miho] Saitama Prefectural Univ, Sch Hlth & Social Serv, 820 Sannomiya, Koshigaya 3438540, Japan; [Yoshida, Yasuko] Sumica Chem Anal Serv Ltd, Environm Hlth & Safety Div, Bunkyo Ku, Sumitomo Fudosan Hongo Bldg 9F,22-5,Hongo 3 Chome, Tokyo 1130033, Japan; [Ookubo, Kaori] Saga Prefectural Inst Publ Hlth & Pharmaceut Res, Phys & Chem Res & Investigate Div, 1-20 Hacchonawatemachi, Saga 8490925, Japan; [Takino, Masahiko] Agilent Technol Japan Ltd, Chromatog & Mass Spectrometry Div, 9-1 Takakura Machi, Hachioji, Tokyo 1920033, Japan; [Hasegawa, Hitomi] Nagoya City Environm Sci Res Inst, Water Qual Div, Minami Ku, 5-16-8 Toyoda, Nagoya, Aichi 4570841, Japan; [Takazawa, Mari] Publ Works Res Inst, Water Environm Res Grp, 1-6 Minamihara, Tsukuba, Ibaraki, Japan; [Takemine, Shusuke] Ctr Environm Sci Saitama, Chem Subst Team, 914 Oaza Kamitanadare,Kisai Machi, Kazo, Saitama 3470115, Japan in 2021.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Despite the increasing detection of emerging substances in the environment, the identity of most are left unknown due to the lack of efficient identification methods. We developed a non-target analysis method for identifying unknown substances in the environment by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) with a product ion and neutral loss database (PNDB). The present analysis describes an elucidation method with elemental compositions of the molecules, product ions, and corresponding neutral losses of the unknown substance: (1) with the molecular formula, possible molecular structures are retrieved from two chemical structure databases (PubChem and ChemSpider); then (2) with the elemental compositions of product ions and neutral losses, possible partial structures are retrieved from the PNDB; and finally, (3) molecular structures that match the possible partial structures are listed in order of number of hits. A molecular structure with a higher number of hits is more similar to the structure of the analyzed substance. The performance of the non-target method was evaluated by simulated analysis of 150 LC/HRMS spectra registered in MassBank. First, all substances of the same mass data (41/41) and 68% (39/57) of the mass data of the same substances not registered in the PNDB were elucidated. It was demonstrated that 14% (7/52) and 31% (16/52) of the substances with no mass spectral data registered in the PNDB were obtained at the first and within the fifth place, respectively. Owing to the fact that 10 of the total hits occurred in product ions and neutral losses, almost 50% of the substances evaluated with this method were placed at the top 4 positions in the similarity ranking. Importantly, the proposed method is effective for analyzing mass spectral data that has not been registered in the PNDB and thus is expected to be used for a variety of non-target analyses.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Downstream Synthetic Route Of 61-82-5

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY or concate me.

Recently I am researching about COORDINATION POLYMERS; CRYSTAL-STRUCTURES; UNITS; SEPARATION; CH4; CO2; PERFORMANCE; STABILITY; TOPOLOGY; LIGANDS, Saw an article supported by the Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_2109]; Natural Science Foundation of Jiangsu Normal University, China [17XLR044]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Two metal-organic frameworks, [Zn-2(atrz)(2)(bpdc)]center dot 0.5H(2)O (1) and [Zn-2(mtrz)(2)(azdc)]center dot DMA center dot CH3OH center dot H2O (2), with 3-substitued 1,2,4-triazole (Hatrz = 3-amino-1,2,4-triazole, Hmtrz = 3-methyl-1,2,4-triazole) have been constructed. Both MOFs possess 3D self-penetrated frameworks featuring Zn-triazolate layers pillared by dicarboxylate ligands (H(2)bdc = 1,4-benzenedicarboxylate, H(2)azdc = azobenzene-4,4′-dicarboxylate). In particular, 2 exhibits a rare rob network with the dimeric Zn-triazolate as the 6-connected nodes, which resulted from the synergistic effects of both 3-substitued group of triazolate and size-alterable dicarboxylate pillar on the final frameworks. Detailed structural analysis of 1 and 2 and its comparison with commonly observed pcu net in pillared-layer structure has been presented. Pore-size tuning and functionalities have also been achieved related to diverse molecular length of pillars. 2 with long pillar displays suitable pore size, and consequently, demonstrates selective CO2 uptake and efficient dyes adsorption in aqueous solution based on size-exclusion effect. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, J; Wei, YH; Bao, FL; Li, GX; Liu, HY; Wang, HY or concate me.

Brief introduction of C2H4N4

SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.

Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP in [Goncharova, O. A.; Kuznetsov, D. S.; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia published Chamber Inhibitors of Corrosion of AMg6 Aluminum Alloy in 2020.0, Cited 17.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (potentiometric anode polarization and electrochemical impedance spectroscopy), and corrosion (periodic moisture condensation test) methods, the properties of adsorption films formed on the AMg6 aluminum alloy surface by the chamber method in vapors of some amines of heterocyclic compounds, carboxylic acids, and their salts are studied. It is established that the use of the studied compounds in the chamber processing of the alloy increases-though not effectively enough-its corrosion resistance in a humid atmosphere. The most promising inhibitors are carboxylic acids themselves; the optimum temperature for surface treatment with them is 140 degrees C. One-hour treatment of steel with pairs of oleic, neodecanoic acid, and carboxylic acid A at this temperature gives rise to the formation of nanoscale adsorption films on the AMg6 alloy, which slightly hydrophilize the surface, but possess a protective aftereffect. Apparently, further improvement of chamber protection methods of the AMg6 alloy should consist in the selection of synergists for chamber corrosion inhibitors of the carboxylate type.

SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.

You Should Know Something about C2H4N4

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, PD; Wu, XQ; He, T; Xie, LH; Chen, Q; Li, JR or concate me.

In 2020.0 CHEM COMMUN published article about PROPANE in [Li, Jian-Rong] Beijing Univ Technol, Beijing Key Lab Green Catalysis & Separat, Coll Environm & Energy Engn, Beijing 100124, Peoples R China; Beijing Univ Technol, Dept Chem & Chem Engn, Coll Environm & Energy Engn, Beijing 100124, Peoples R China in 2020.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

The selective adsorption/separation of C-2 hydrocarbons has been realized in a flexible-robust MOF, Zn-2(Atz)(2)Ox. Owing to the distinctive guest-dependent multistep adsorption behaviors and suitable guest-framework interactions, this MOF shows outstanding separation performance for C2H2/C2H4 mixtures in a wide range of temperature confirmed by a column breakthrough experiment.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, PD; Wu, XQ; He, T; Xie, LH; Chen, Q; Li, JR or concate me.

Search for chemical structures by a sketch :61-82-5

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Chen, S; Wang, YT; An, ZH; Ma, M; Shi, YQ; Wang, X or concate me.

An article Stability, antibacterial ability, and inhibition of zinc burning of amitrole as thermal stabilizer for transparent poly(vinyl chloride) WOS:000470329700008 published article about DERIVATIVES; EFFICIENCY; FRAMEWORKS; MECHANISM; PVC in [Chen, Si; Wang, Yating; An, Zhihang; Ma, Meng; Shi, Yanqin; Wang, Xu] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Amitrole is reported as a novel kind of transparent poly(vinyl chloride) (PVC) thermal stabilizer that has both excellent inhibition of zinc burning thermal stability and antibacterial ability in this paper, which provide the possibility of applying the whole PVC industry into medical and food packaging, artificial leather, wire and cable, indoor decoration, and so on. From the results of Congo red test, discoloration test, and dynamic thermal stability test, we could clearly find out that amitrole could effectively replace the unstable chlorine atom and inhibit zinc burning of transparent PVC, while the long-term stability should be improved. Next, the stabilization mechanism of amitrole was also confirmed. The antibacterial activity of amitrole was measured by the bacteriostatic ring experiments. It was observed that the PVC films had good antibacterial properties after modified by amitrole. At last, optimal design of the amitrole/ZnSt(2) (1:1)/ESBO formulation was studied, which have strong potential as thermal stabilizer to prepare super transparency and antibacterial PVC resin.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Chen, S; Wang, YT; An, ZH; Ma, M; Shi, YQ; Wang, X or concate me.

Never Underestimate The Influence Of 1H-1,2,4-Triazol-5-amine

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

I found the field of Microbiology very interesting. Saw the article A pilin chaperone required for the expression of electrically conductive Geobacter sulfurreducens pili published in 2019.0. Safety of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Zhou, SG (corresponding author), Fujian Agr & Forestry Univ, Coll Resources & Environm, Fujian Prov Key Lab Soil Environm Hlth & Regulat, Fuzhou, Fujian, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Mechanisms controlling the expression of the electrically conductive pili (e-pili) of Geobacter species are of interest because of the important role of e-pili in diverse biogeochemical processes, anaerobic digestion and electromicrobiological applications. We investigated the function of the protein, designated Spc (short pilin chaperone), encoded by the gene immediately downstream from the gene for PilA, the monomer that assembles into e-pili. Multiple lines of evidence suggest that Spc forms an oligomer that is associated with the inner membrane. Mutating the start codon of spc to prevent translation increased the transcript abundance of pilA but greatly diminished the abundance of PilA, and e-pili could no longer be detected. Cross-linking, protein capture and two-hybrid studies demonstrated that Spc and PilA interacted. Two sites in PilA for electrostatic interaction with Spc were identified. The results demonstrate that Spc is required for PilA stability prior to incorporation into e-pili, suggesting that Spc has a chaperone function that may be specific to the relatively short PilA monomers that assemble into e-pili. These results are important for identifying microorganisms likely to express e-pili from (meta)genomic data and for the construction of microbial strains expressing e-pili.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, X; Zhan, J; Jing, XY; Zhou, SG; Lovley, DR or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

When did you first realize you had a special interest and talent in61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.. COA of Formula: C2H4N4

An article Mesoporous Polymeric Cyanamide-Triazole-Heptazine Photocatalysts for Highly-Efficient Water Splitting WOS:000558656000001 published article about GRAPHITIC CARBON NITRIDE; HYDROGEN EVOLUTION; FACILE SYNTHESIS; SEMICONDUCTORS; REDUCTION; NITROGEN; PERFORMANCE; PRECURSORS; NANOSHEETS; STRATEGY in [Wu, Chongbei; Yu, Guanhang; Yin, Yue; Wang, Yuze; Chen, Li; Han, Qing; Wang, Bo] Beijing Inst Technol, Key Lab Cluster Sci, Key Lab Photoelect Electrophoton Convers Mat, Minist Educ China,Sch Chem & Chem Engn, Beijing 100081, Peoples R China; [Tang, Junwang] UCL, Dept Chem Engn, London WC1E 7JE, England in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

Conjugated polymers are promising light harvesters for water reduction/oxidation due to their simple synthesis and adjustable bandgap. Herein, both cyanamide and triazole functional groups are first incorporated into a heptazine-based carbon nitride (CN) polymer, resulting in a mesoporous conjugated cyanamide-triazole-heptazine polymer (CTHP) with different compositions by increasing the quantity of cyanamide/triazole units in the CN backbone. Varying the compositions of CTHP modulates its electronic structures, mesoporous morphologies, and redox energies, resulting in a significantly improved photocatalytic performance for both H(2)and O(2)evolution under visible light irradiation. A remarkable H(2)evolution rate of 12723 mu mol h(-1)g(-1)is observed, resulting in a high apparent quantum yield of 11.97% at 400 nm. In parallel, the optimized photocatalyst also exhibits an O(2)evolution rate of 221 mu mol h(-1) g(-1), 9.6 times higher than the CN counterpart, with the value being the highest among the reported CN-based bifunctional photocatalysts. This work provides an efficient molecular engineering approach for the rational design of functional polymeric photocatalysts.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.. COA of Formula: C2H4N4

An overview of features, applications of compound:C2H4N4

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wang, S; Zhao, LJ; Shi, XJ; Ding, LN; Yang, LL; Wang, ZZ; Shen, DD; Tang, K; Li, XJ; Mamun, MAA; Li, HJ; Yu, B; Zheng, YC; Wang, SM; Liu, HM or concate me.

An article Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction WOS:000461537000036 published article about CULLIN-RING LIGASES; NEDD8-ACTIVATING ENZYME; E3 LIGASE; DEGRADATION; NEDDYLATION; DISCOVERY; CARCINOMA; UBIQUITINATION; AMPLIFICATION; PROGRESSION in [Wang, Shuai; Zhao, Lijie; Shi, Xiao-Jing; Ding, Lina; Wang, Zhi-Zheng; Shen, Dandan; Tang, Kai; Li, Xiao-Jing; Mamun, M. A. A.; Li, Huiju; Yu, Bin; Zheng, Yi-Chao; Wang, Shaomeng; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Wang, Shuai; Zhao, Lijie; Shi, Xiao-Jing; Ding, Lina; Wang, Zhi-Zheng; Shen, Dandan; Tang, Kai; Li, Xiao-Jing; Mamun, M. A. A.; Li, Huiju; Yu, Bin; Zheng, Yi-Chao; Wang, Shaomeng; Liu, Hong-Min] Zhengzhou Univ, Inst Drug Discovery & Dev, Zhengzhou 450001, Henan, Peoples R China; [Wang, Shaomeng] Univ Michigan, Dept Internal Med, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Dept Pharmacol, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA; [Wang, Shaomeng] Univ Michigan, Dept Med Chem, 1600 Huron Pkwy, Ann Arbor, MI 48109 USA; [Wang, Shuai; Zhao, Lijie; Shi, Xiao-Jing; Ding, Lina; Wang, Zhi-Zheng; Shen, Dandan; Tang, Kai; Li, Xiao-Jing; Mamun, M. A. A.; Li, Huiju; Yu, Bin; Zheng, Yi-Chao; Liu, Hong-Min] Coinnovat Ctr Henan Prov New Drug R&D Preclin Saf, Zhengzhou 450001, Henan, Peoples R China; [Wang, Shuai; Zhao, Lijie; Shi, Xiao-Jing; Ding, Lina; Wang, Zhi-Zheng; Shen, Dandan; Tang, Kai; Li, Xiao-Jing; Mamun, M. A. A.; Li, Huiju; Yu, Bin; Zheng, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Minist Educ China, Key Lab Adv Technol Drug Preparat Technol, Zhengzhou 450001, Henan, Peoples R China; [Yang, Linlin] Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou 450001, Henan, Peoples R China; [Yu, Bin] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China in 2019.0, Cited 53.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The cullin-RING ubiquitin ligases (CRLs) are responsible for about 20% of cellular protein degradation and regulate diverse cellular processes, and the dysfunction of CRLs is implicated in human diseases. Targeting the CRLs has become an emerging strategy for the treatment of human diseases. Herein, we describe the discovery of a hit compound from our in-house library and further structure-based optimizations, which have enabled the identification of new triazolo[1,5-a]pyrimidine-based inhibitors targeting the DCN1-UBC12 interaction. Compound WS-383 blocks the DCN1-UBC12 interaction (IC50 = 11 nM) reversibly and shows selectivity over selected kinases. WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells. WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27, and NRF2. Collectively, targeting the DCN1-UBC12 interaction would be a viable strategy for selective neddylation inhibition of Cul3/1 and may be of therapeutic potential for disease treatment in which Cul3/1 is dysregulated.

New learning discoveries about 1H-1,2,4-Triazol-5-amine

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JH; Jin, B; Peng, RF; Niu, CH; Xiao, LPC; Guo, ZC; Zhang, QC or concate me.

An article Novel strategies for synthesizing energetic materials based on BTO with improved performances WOS:000479086800023 published article about SENSITIVITY; COCRYSTAL; SALTS; DESIGN in [Zhang, Jinhao; Jin, Bo; Peng, Rufang; Niu, Chunhuan; Xiao, Lipengcheng; Guo, Zhicheng; Zhang, Qingchun] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Sichuan, Peoples R China in 2019.0, Cited 40.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

The layer-by-layer assembly of molecules is ubiquitous in nature. Highly ordered structures formed in this manner often exhibit fascinating material properties. A layer hydrogen bonding pairing approach allows the development of tunable energetic materials with targeted properties. A series of unusual energetic compounds based on 1H,1 ‘ H-5,5 ‘-bistetrazole-1,1 ‘-diolate (1), such as the salts of 3-amino-1,2,4-triazolium (2), aminoguanidinium (3), and hydrazinium (4), and the cocrystals of 4-amino-1H-pyrazole (5), 2-methylimidazole (6), and imidazole (7), were synthesized using this strategy. The structures of the obtained products 2-7 were fully characterized by elemental analysis, IR spectroscopy, H-1 NMR and C-13 NMR spectroscopy, and single-crystal X-ray analysis. Their thermal decomposition behavior was studied by differential scanning calorimetry and thermogravimetry. Their mechanical sensitivities and detonation performances were also analyzed in detail. Results show that products 2-7 exhibit higher density, better detonation performances, and more excellent sensitivities than those of the same species of cation salts previously reported.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JH; Jin, B; Peng, RF; Niu, CH; Xiao, LPC; Guo, ZC; Zhang, QC or concate me.

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Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Colombo, M; Masiero, S; Rosa, S; Caporali, E; Toffolatti, SL; Mizzotti, C; Tadini, L; Rossi, F; Pellegrino, S; Musetti, R; Velasco, R; Perazzolli, M; Vezzulli, S; Pesaresi, P or concate me.

An article NoPv1: a synthetic antimicrobial peptide aptamer targeting the causal agents of grapevine downy mildew and potato late blight WOS:000585845700018 published article about PLASMOPARA-VITICOLA; PESTICIDE-RESIDUES; CELLULOSE SYNTHASE; RESISTANCE; MECHANISMS; PATHOGEN; EXPOSURE; DEFENSE; DOMAIN; BIOSYNTHESIS in [Colombo, Monica; Perazzolli, Michele; Vezzulli, Silvia] Fdn Edmund Mach, Res & Innovat Ctr, San Michele All Adige, Italy; [Masiero, Simona; Rosa, Stefano; Caporali, Elisabetta; Mizzotti, Chiara; Tadini, Luca; Pesaresi, Paolo] Univ Milan, Dept Biosci, Milan, Italy; [Toffolatti, Silvia Laura] Univ Milan, Dept Agr & Environm Sci DISAA, Milan, Italy; [Rossi, Fabio] Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Milan, Italy; [Pellegrino, Sara] Univ Milan, DISFARM Dept Pharmaceut Sci, Milan, Italy; [Musetti, Rita] Univ Udine, Dept Agr Food Environm & Anim Sci, Udine, Italy; [Velasco, Riccardo] CREA Res Ctr Viticulture & Enol, Conegliano, TV, Italy; [Perazzolli, Michele] Univ Trento, Ctr Agr Food Environm C3A, San Michele All Adige, Italy in 2020.0, Cited 81.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Grapevine (Vitis vinifera L.) is a crop of major economic importance. However, grapevine yield is guaranteed by the massive use of pesticides to counteract pathogen infections. Under temperate-humid climate conditions, downy mildew is a primary threat for viticulture. Downy mildew is caused by the biotrophic oomycete Plasmopara viticola Berl. & de Toni, which can attack grapevine green tissues. In lack of treatments and with favourable weather conditions, downy mildew can devastate up to 75% of grape cultivation in one season and weaken newly born shoots, causing serious economic losses. Nevertheless, the repeated and massive use of some fungicides can lead to environmental pollution, negative impact on non-targeted organisms, development of resistance, residual toxicity and can foster human health concerns. In this manuscript, we provide an innovative approach to obtain specific pathogen protection for plants. By using the yeast two-hybrid approach and the P. viticola cellulose synthase 2 (PvCesA2), as target enzyme, we screened a combinatorial 8 amino acid peptide library with the aim to identify interacting peptides, potentially able to inhibit PvCesa2. Here, we demonstrate that the NoPv1 peptide aptamer prevents P. viticola germ tube formation and grapevine leaf infection without affecting the growth of non-target organisms and without being toxic for human cells. Furthermore, NoPv1 is also able to counteract Phytophthora infestans growth, the causal agent of late blight in potato and tomato, possibly as a consequence of the high amino acid sequence similarity between P. viticola and P. infestans cellulose synthase enzymes.