61-82-5 -| Page 105 of 154

New learning discoveries about 61-82-5

Computed Properties of C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, DC; Xin, YY; Li, XQ; Ning, HL; Wang, YD; Yao, DD; Zheng, YP; Meng, ZY; Yang, ZY; Pan, YT; Li, PP; Wang, HN; He, ZJ; Fan, WD or send Email.

In 2021.0 ACS APPL MATER INTER published article about CARBON; MEMBRANES; SEPARATION; UIO-66; NANOPARTICLES; ADSORPTION; SIMULATION; DIFFUSION; CAPACITY; PLATFORM in [Wang, Dechao; Xin, Yangyang; Li, Xiaoqian; Wang, Yudeng; Yao, Dongdong; Zheng, Yaping; Wang, Hongni; He, Zhongjie; Fan, Wendi] Northwestern Polytech Univ, Sch Chem & Chem Engn, Xian 710129, Peoples R China; [Ning, Hailong; Meng, Zhuoyue; Yang, Zhiyuan] Xian Univ Sci & Technol, Coll Chem & Chem Engn, Xian 710021, Peoples R China; [Pan, Yuting] Northwestern Polytech Univ, Queen Mary Univ London, Engn Sch, Xian 710129, Shaanxi, Peoples R China; [Li, Peipei] Xidian Univ, Sch Adv Mat & Nanotechnol, Xian 710071, Shaanxi, Peoples R China; [Yang, Zhiyuan] Minist Nat Resources, Key Lab Coal Resources Explorat & Comprehens Util, Xian 710021, Peoples R China in 2021.0, Cited 74.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

Porous liquids (PLs), an emerging kind of liquid materials with permanent porosity, have attracted increasing attention in gas capture. However, directly turning metal-organic frameworks (MOFs) into PLs via a covalent linkage surface engineering strategy has not been reported. Additionally, challenges including reducing the cost and simplifying the preparation process are daunting. Herein, we proposed a general method to transform Universitetet i Oslo (UiO)-66-OH MOFs into PLs by surface engineering with organosilane (OS) and oligomer species via covalent bonding linkage. The oligomer species endow UiO-66OH with superior fluidity at room temperature. Meanwhile, the resulting PLs showed great potential in both CO2 adsorption and CO2/N-2 selective separation. The residual porosity of PLs was verified by diverse characterizations and molecular simulations. Besides, CO2 selective capture sites were determined by grand canonical Monte Carlo (GCMC) simulation. Furthermore, the universality of the covalent linkage surface engineering strategy was confirmed using different classes of oligomer species and another MOF (ZIF-8-bearing amino groups). Notably, this strategy can be extended to construct other PLs by taking advantages of the rich library of oligomer species, thus making PLs promising candidates for further applications in energy and environment-related fields, such as gas capture, separation, and catalysis.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

How did you first get involved in researching 1H-1,2,4-Triazol-5-amine

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Fahim, AM; Shalaby, MA or send Email.

An article Synthesis, biological evaluation, molecular docking and DFT calculations of novel benzenesulfonamide derivatives WOS:000449310600041 published article about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES in [Fahim, Asmaa M.] Natl Res Ctr, Dept Green Chem, POB 12622, Cairo, Egypt; [Shalaby, Mona A.] Damietta Univ, Fac Sci, Dept Chem, New Damietta 34517, Egypt in 2019.0, Cited 88.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Fahim, AM; Shalaby, MA or send Email.

Discover the magic of the 61-82-5

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Ilager, D; Seo, H; Shetti, NP; Kalanur, SS or send Email.

I found the field of Engineering very interesting. Saw the article CTAB modified Fe-WO3 as an electrochemical detector of amitrole by catalytic oxidation published in 2020.0. Product Details of 61-82-5, Reprint Addresses Shetti, NP (corresponding author), KLE Inst Technol, Ctr Electrochem Sci & Mat, Dept Chem, Hubballi 580027, Karnataka, India.; Kalanur, SS (corresponding author), Ajou Univ, Dept Mat Sci & Engn, Suwon 16499, South Korea.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The increasing health risk associated with the exposure to mutagenic, teratogenic and carcinogenic herbicide the environment has encouraged a significant interest towards the development of rapid and cheaper detection technologies for the accurate quantification. The present work involves the exploitation of catalytic oxidation herbicide, amitrole (AMT) at iron doped tungsten oxide (Fe-WO3) nanoparticles and cationic surfactant cetyltrimethylammonium bromide (CTAB) based carbon paste electrode for the sensitive quantification. The working electrode assembly of Fe-WO3/CTAB causes the catalytic oxidation via faster electron transfer compared to bare electrode. Furthermore, the physiochemical properties and thermodynamic properties of AMT were explored. Under the optimized conditions, the modified sensor exhibits good linear detection range (5.0 x 10(-8) M to 8.0 x 10(-5) M), lower limit of detection (0.82 nM) and limit of quantification (2.82 nM) by square wave voltammetric (SWV) technique. Hence, developed senor showed an intensification of peak current of AMT with significant sensitivity, selectivity and reproducibility for AMT analysis and received acceptable results indicates the application of sensors for the analysis of AMT in water as well as soil samples.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Ilager, D; Seo, H; Shetti, NP; Kalanur, SS or send Email.

Discovery of 61-82-5

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Abdelhamid, AO; Gomha, SM; El-Enany, WAMA or send Email.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry very interesting. Saw the article Efficient Synthesis and Antimicrobial Evaluation of New Azolopyrimidines-Bearing Pyrazole Moiety published in 2019.0, Reprint Addresses Gomha, SM (corresponding author), Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt.; Gomha, SM (corresponding author), Islamic Univ Almadinah Almonawara, Fac Sci, Dept Chem, Almadinah Almonawara 42351, Saudi Arabia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Sodium salt of 3-hydroxy-1-(1-aryl-5-methylpyrazolyl)propenone derivatives was used as a precursor for synthesis of various fused azolopyrimidine ring systems as pyrazolopyrimidines, triazolopyrimidines, and pyrimidobenzimidazoles following many procedures. The identity of the prepared compounds was elucidated by their spectral data and elemental analyses. The in vitro antimicrobial activity of 13 new compounds was evaluated, and many derivatives showed good to moderate activity.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Abdelhamid, AO; Gomha, SM; El-Enany, WAMA or send Email.

Never Underestimate The Influence Of 1H-1,2,4-Triazol-5-amine

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Wei, YJ; Gao, J; Feng, Y; Wang, N; Gao, JF or send Email.

Recently I am researching about EFFICIENT CARBOCATALYST; NANOPARTICLES; GRAPHENE; ACID; NANOSPHERES; PERFORMANCE; ELECTRODES; OXIDATION, Saw an article supported by the project of Hebei Province Natural and Scientific Foundation [B2017101022, B2017101018]; project of Chengde Science and Technology Bureau [201606A069]; young foundation project of Hebei Province Educational Bureau [QN2017408]; top talent project of Hebei Province Educational Bureau [BJ2018208]; science and technology Support Program of Hebei Province [16211113]. Recommanded Product: 1H-1,2,4-Triazol-5-amine. Published in WORLD SCIENTIFIC PUBL CO PTE LTD in SINGAPORE ,Authors: Zhou, SH; Xu, HB; Wei, YJ; Gao, J; Feng, Y; Wang, N; Gao, JF. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Heteroatom-doped ordered mesoporous carbons (OMCs) have currently been considered as promising electrode materials for electrochemical sensors due to the combined advantages of ordered mesoporous materials and heteroatom-doped carbon materials. Herein, a novel nitrogen and sulfur co-doped OMCs (N,S-OMC) has been prepared via a nanocasting strategy with an inexpensive methylene blue as single precursor. The obtained mesoporous carbon has platelet morphology, short mesoporous channel together with a large surface area (549 m(2)/g) as well as rich N- and S-containing functional groups (6.8 at.% N and 2.3 at.% S). Compared with the graphene (GR) and carbon nanotube (CNT) electrode material, the N,S-OMC exhibited a higher electrochemical activity towards the oxidation of herbicide amitrole, ascribable to N,S-OMC’s open mesoporous structures and abundant electroactive defect sites on the carbon skeleton. And, an amitrole electrochemical sensor with N,S-OMC modified electrode as working electrode was fabricated, exhibiting a good selectivity, stability, reproducibility and wide linear range of 3-750 mu M. Moreover, the N,S-OMC-based electrochemical sensor was proved feasible in river water sample analyses, showing a satisfied recovery ranging from 97.03% to 105.42%. The results not only demonstrate cheap methylene blue can be used as single precursor for the N,S-OMC preparation, but also confirm the N,S-OMC is promising in amitrole sensor fabrication.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhou, SH; Xu, HB; Wei, YJ; Gao, J; Feng, Y; Wang, N; Gao, JF or send Email.

When did you first realize you had a special interest and talent in61-82-5

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Voitekhovich, SV; Grigoriev, YV; Lyakhov, AS; Matulis, VE; Ivashkevich, LS; Bogomyakov, AS; Lavrenova, LG; Ivashkevich, OA or send Email.

I found the field of Chemistry; Crystallography very interesting. Saw the article 1-(1,2,4-Triazol-3-yl)-1H-tetrazoles and their complexation with copper (II) chloride published in 2020.0. Product Details of 61-82-5, Reprint Addresses Voitekhovich, SV (corresponding author), Belarusian State Univ, Res Inst Phys Chem Problems, Leningradskaya 14, Minsk 220006, BELARUS.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

1-(1,2,4-Triazol-3-yl)-1H-tetrazole (trt) and 1-(1-tert-butyl-1,2,4-triazol-3-yl)-1H-tetrazole (btrt) were synthesized by heterocyclization of corresponding amines with triethyl orthoformate and sodium azide. The interaction of trt with copper(II) chloride in ethanol in the presence of hydrochloric acid was found to result in 10 coordination polymer [CuCl2(trt)(H2O)](n)center dot nH(2)O. N-tert-butylated ligand btrt reacts with the copper salt in ethanol giving 2D coordination polymer [CuCl2(btrt)](n). Tetrazole ring-opening reaction with the formation of [CuCl2(3-amino-1,2,4-triazolium)(2)][CuCl4]center dot 2H(2)O was observed in the interaction of trt with copper(II) chloride in aqueous hydrochloric acid. The temperature-dependent magnetic susceptibility measurements of [CuCl2(btrt)](n) revealed that the copper(II) ions were weakly ferromagnetically coupled showing a coupling constant J of 1.2 cm(-1). (C) 2019 Elsevier Ltd. All rights reserved.

Archives for Chemistry Experiments of C2H4N4

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, Z; Lu, Y; Zhang, S; Sun, XW; Dang, TY; Zhang, Z; Tian, HR; Liu, SX or send Email.

Recently I am researching about METAL-ORGANIC FRAMEWORKS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21872021, 21671033]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Li, Z; Lu, Y; Zhang, S; Sun, XW; Dang, TY; Zhang, Z; Tian, HR; Liu, SX. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. HPLC of Formula: C2H4N4

Nowadays, the research of proton conductive materials has been extended from traditional sulfonated polymers to novel crystalline solid materials. It is important but still challenging to develop high-performance proton-conducting materials suitable for proton exchange membrane fuel cells (PEMFCs). Considering the features of molybdenum oxide and triazole in the construction of proton-conducting material, two triazole-modified molybdenum oxides, [MoO3(trz)(0.5)]1and [H(atrz)(4)[(atrz)(2)(gamma-Mo8O26)] . 2H(2)O2(trz=1,2,4-triazole, atrz=3-amino-1,2,4-triazole), were re-synthesized under optimized synthetic conditions, and their proton-conducting performances were investigated.1and2show high proton conductivities of 1.94×10(-2) S cm(-1)(85 degrees C, 95 % RH) and 1.3×10(-3) S cm(-1)(65 degrees C, 95 % RH), respectively.

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, Z; Lu, Y; Zhang, S; Sun, XW; Dang, TY; Zhang, Z; Tian, HR; Liu, SX or send Email.

When did you first realize you had a special interest and talent in1H-1,2,4-Triazol-5-amine

SDS of cas: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact El Sayed, MT; Sarhan, AE; Ahmed, E; Khattab, RR; Elnaggar, M; El-Messery, SM; Shaldam, MA; Hassan, GS or send Email.

In 2020.0 CHEMISTRYSELECT published article about TRANSITION-METAL COMPOUNDS; DENSITY-FUNCTIONAL THEORY; MOLECULAR-STRUCTURES; DOCKING; MOLYBDENUM; INDOLES; MANNICH; BONDS in [El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Dokki 12311, Egypt; [Sarhan, Alaadin E.] Natl Res Ctr, Pharmaceut Div, Therapeut Chem Dept, Dokki 12311, Egypt; [Ahmed, Entsar] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, Cairo, Egypt; [Khattab, Reham R.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Dokki 12311, Egypt; [Elnaggar, Mohamed] Univ Sharjah, Fac Sci, Chem Dept, Sharjah 27272, U Arab Emirates; [El-Messery, Shahenda M.] Mansoura Univ, Fac Pharm, Dept Organ Pharmaceut Chem, POB 35516, Mansoura, Egypt; [Shaldam, Moataz A.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, Kafr Al Sheikh 33516, Egypt; [Hassan, Ghada S.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt in 2020.0, Cited 39.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

In the present investigation, some novel nitro Mannich bases derived from Michael type addition of activated nitro olefin, beta-nitrostyrene with various amines either primary or secondary including some amino sugars were designed and synthesized. The produced Mannich bases have been full characterized through different spectroscopic techniques. Antimicrobial evaluation has been performed against the Gram positive S. aureus and methicillin-resistant S. aurues (MRSA) infections. 5 of the synthesized compounds represent the best candidates in the biological screening, they have exhibited good activity with MIC values range from 100 to 250 mu g/ml. The active agents have been tested for pyruvate kinase inhibition activity with % of inhibition range from 30 to 79 % with IC50 in a nano molar range. They also exhibited significant Pyruvate kinase inhibition in nanomolar range with IC50 of 1066, 662, 1887, 418 and 1128 ng/ml, respectively (versus 196 ng/ml for AZD7545). Molecular docking calculations for active agents were performed. A complete conformational analysis molecular modeling utilizing Gaussian 09 program (HF/DFT) was used to verify the mode of bonding through the optimized geometries as well as essential quantum parameters were calculated using frontier energies (EHOMO & ELUMO) for the active candidates indicating the overall stability of the structure.

Chemical Research in C2H4N4

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or send Email.

An article Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins WOS:000486630100009 published article about KINASE INHIBITORS; STRUCTURAL BASIS; ATPASE; P97; CANCER; MECHANISMS; UBIQUITIN; VCP/P97; SPASTIN; POTENT in [Pisa, Rudolf; Cupido, Tommaso; Steinman, Jonathan B.; Jones, Natalie H.; Kapoor, Tarun M.] Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA; [Pisa, Rudolf; Jones, Natalie H.] Rockefeller Univ, Triinst PhD Program Chem Biol, New York, NY 10065 USA; [Steinman, Jonathan B.] Weill Cornell Rockefeller Sloan Kettering Triinst, New York, NY 10065 USA in 2019.0, Cited 45.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or send Email.

A new application about61-82-5

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Lauar, MR; Blanch, GT; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or send Email.

An article Anti-hypertensive effect of hydrogen peroxide acting centrally WOS:000535871700001 published article about RENIN-ANGIOTENSIN SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANTEROVENTRAL 3RD-VENTRICLE AV3V; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; RENAL-HYPERTENSION; PRESSOR-RESPONSES; BLOOD-PRESSURE; RENOVASCULAR HYPERTENSION; CARDIOVASCULAR-RESPONSES in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ, Dent Sch, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil; [Blanch, Graziela T.] Pontifical Catholic Univ Goias, Sch Med Pharm & Biomed, Goiania, Go, Brazil in 2020.0, Cited 69.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 mu mol/1 mu l) or ATZ (5 nmol/1 mu l) icv reduced the pressor responses to ANG II (50 ng/1 mu l) icv in SHRs (11 +/- 3 and 17 +/- 4 mmHg, respectively, vs. 35 +/- 6 mmHg) and 2K1C hypertensive rats (3 +/- 1 and 16 +/- 3 mmHg, respectively, vs. 26 +/- 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.