Category: 56602-33-6

In 2015,Konno, Hiroyuki; Abumi, Kanako; Sasaki, Yasuhiro; Yano, Shigekazu; Nosaka, Kazuto published 《Structure activity relationship study of burkholdine analogues toward simple antifungal agents》.Bioorganic & Medicinal Chemistry Letters published the findings.COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:

Cyclic and linear lipopeptides, burkholdine analogs, were synthesized by conventional Fmoc-SPPS (Fmoc = tert-butoxycarabonyle) and cyclization with DIPC/HOBt in the solution phase. Synthesized peptides were evaluated for antifungal activities with MIC values against Saccharomyces cerevisiae and Aspergillus oryzae. As a result, the stereochem. of the amino acid residues and sequences of burkholdine analogs exerted a significant influence on antifungal activities. In addition, we found a linear burkholdine analog with moderate antifungal activities. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core》 was written by Wang, Yueliang; Xing, Li; Ji, Yinchun; Ye, Jiqing; Dai, Yang; Gu, Wangting; Ai, Jing; Song, Zilan. Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)This research focused ontyrosine kinase AXL kinase inhibitor pyrazine antiproliferative cancer; AXL Kinase; Cancer; Pyrazine. The article conveys some information:

Starting from the recently launched FLT3/AXL multi-targeted inhibitor Gilteritinib (5), we conducted a side-chain ring closure medicinal chem. approach leading to the identification of compound 15c as a highly potent AXL inhibitor in the biochem. and cellular anti-proliferative assays, with IC50 values of 1.2 and 0.3 nM, resp. Compared with the reference compound 5, our new discovered AXL inhibitor 15c is more potent in both assays. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2015 ,《Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: Use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group》 appeared in Organic & Biomolecular Chemistry. The author of the article were ElMarrouni, Abdellatif; Heras, Montserrat. The article conveys some information:

The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic substitution reaction between 4-[4-(benzyloxy)benzyloxy]-2-(benzylsulfonyl)pyrimidine and the nucleophilic side chain of several Nα-Boc amino esters (Boc = tert-butoxycarbonyl), as the key step, followed by a series of standard protecting group transformations. P-Benzyloxybenzyloxy is efficiently removed under mild acid conditions to recover the 4(3H)-pyrimidinone system. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Sciortino, Flavien; Rydzek, Gaulthier; Grasset, Fabien; Kahn, Myrtil L.; Hill, Jonathan P.; Chevance, Soizic; Gauffre, Fabienne; Ariga, Katsuhiko published 《Electro-click construction of hybrid nanocapsule films with triggered delivery properties》.Physical Chemistry Chemical Physics published the findings.HPLC of Formula: 56602-33-6 The information in the text is summarized as follows:

Hollow nanocapsules (named Hybridosomes) possessing a polymer/nanoparticle shell were used to covalently construct hybrid films in a 1-pot fashion. The alkyne bearing organic/inorganic Hybridosomes were reticulated with azide bearing homobifunctional polyethyleneglycol (PEG) linkers, by using an electro-click reaction on F-SnO2 (FTO) electrodes. The coatings were obtained by promoting the Cu(I)-catalyzed click reaction between alkyne and azide moieties in the vicinity of the electrode by the electrochem. generation of Cu(I) ions. The physicochem. properties of the covalently reticulated hybrid films obtained were studied by SEM, AFM, UV-visible and fluorescence spectroscopy. The 1-pot covalent click reaction between the nanocapsules and the PEG linkers in the film did not affect the desirable features of the Hybridosomes i.e. their hollow nanostructure their chem. versatility and their pH-sensitivity. Consequently, both the composition and the cargo-loading of the Hybridosomes films could be tuned, demonstrating the versatility of these hybrid coatings. For example, the Hybridosome films were used to encapsulate and release a bodipy fluorescent probe in response to either a pH drop or the application of an oxidative +1 V potential (vs. Ag/AgCl) at the substrate. By advancing the field of electro-synthesized films a step further toward the design of complex physicochem. interfaces, these results open perspectives for multifunctional coatings where chem. versatility, controllable stability and a hollow nanostructure are required. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6HPLC of Formula: 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.HPLC of Formula: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2019 ,《Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors》 was published in ACS Chemical Neuroscience. The article was written by Yadav-Samudrala, Barkha J.; Eltit, Jose M.; Glennon, Richard A.. The article contains the following contents:

Synthetic cathinones are, primarily, stimulant drugs of abuse that act at monoamine transporters (e.g., the dopamine transporter or DAT) as releasing agents or as reuptake inhibitors. In the past few years, the emergence of >150 new synthetic cathinones has attracted considerable attention from medical and law enforcement communities. Threo-Methylphenidate (tMP), used clin. for the treatment of ADHD and narcolepsy, is also a DAT reuptake inhibitor. TMP is somewhat structurally similar to abused cathinone stimulants, and the structure-activity relationships (SAR) of tMP have been well-defined. Hence, available tMP literature might assist in understanding the SAR of synthetic cathinones, about which less is known. In the present study, we synthesized and examined eight 2-benzoylpiperidine analogs to determine if tMP SAR might be applicable to cathinone SAR. The benzoylpiperidine analogs were evaluated in a competition assay using live-cell imaging against APP+ in HEK293 cells stably expressing hDAT and in cells coexpressing DAT and voltage-gated Ca2+ channels. All compounds were found to be DAT reuptake inhibitors, and a significant correlation was obtained between the potency of the benzoylpiperidines and tMP binding data (r = 0.91), suggesting that the SAR of tMP analogs might be directly applicable to certain synthetic cathinones as DAT reuptake inhibitors. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Application In Synthesis of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: triazolesIn 2016 ,《Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors》 appeared in European Journal of Medicinal Chemistry. The author of the article were Camarasa, Marta; Puig de la Bellacasa, Raimon; Gonzalez, Alex L.; Ondono, Raul; Estrada, Roger; Franco, Sandra; Badia, Roger; Este, Jose; Martinez, Miguel Angel; Teixido, Jordi; Clotet, Bonaventura; Borrell, Jose I.. The article conveys some information:

The design and selection of a combinatorial library of pyrido[2,3-d]pyrimidin-7(8H)-ones allowed the synthesis of 121 compounds, using known and new synthetic methodologies and the evaluation of the inhibitory activity against hepatitis C virus (HCV) genotype 1b replicon. Among these compounds, I and II presented very high activities [EC50 = 0.027 μM (CC50 = 5.3 μM) and EC50 = 0.034 μM (CC50 = 13.5 μM), resp.] and high selectivity indexes, 196 and 397. These values are similar to the EC50 reported for sofosbuvir (2) (0.048 μM) using a similar methodol. approach and the same virus subtype. Compounds I and II and were obtained through shorter synthetic itineraries than sofosbuvir and II was achiral contrary to sofosbuvir which presented 4 stereogenic centers. In-silico studies suggested that I and II inhibited NS5B polymerase through allosteric site binding. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Category: triazoles)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2015,Suhina, Tomislav; Weber, Bart; Carpentier, Chantal E.; Lorincz, Kinga; Schall, Peter; Bonn, Daniel; Brouwer, Albert M. published 《Fluorescence Microscopy Visualization of Contacts Between Objects》.Angewandte Chemie, International Edition published the findings.HPLC of Formula: 56602-33-6 The information in the text is summarized as follows:

The area of contact between two objects was detected by using the strong enhancement of the fluorescence of rigidochromic probe mols. attached to one of the surfaces. Confinement of the mols. suppresses nonradiative decay and turns on the fluorescence. The approach is demonstrated by imaging of the contact area of a plastic sphere in contact with a flat glass surface. Our results agree excellently with the prediction of Hertz’s classical theory based on elastic deformation. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6HPLC of Formula: 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.HPLC of Formula: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,Gross, Andrew J.; Chen, Xiaohong; Giroud, Fabien; Travelet, Christophe; Borsali, Redouane; Cosnier, Serge published 《Redox-active glyconanoparticles as electron shuttles for mediated electron transfer with bilirubin oxidase in solution》.Journal of the American Chemical Society published the findings.SDS of cas: 56602-33-6 The information in the text is summarized as follows:

We demonstrate the self-assembly, characterization, and bioelectrocatalysis of redox-active cyclodextrin-coated nanoparticles. The nanoparticles with host-guest functionality are easy to assemble and permit entrapment of hydrophobic redox mols. in aqueous solution Bis-pyrene-ABTS encapsulated nanoparticles were investigated electrochem. and spectroscopically. Their use as electron shuttles was demonstrated via an intra-electron transfer chain between neighboring redox units of clustered particles (Dh,DLS = 195 nm) and the mono- and trinuclear Cu sites of bilirubin oxidases. Enhanced current densities for mediated O2 reduction were observed with the redox nanoparticle system compared to equivalent bioelectrode cells with a dissolved mediator. Improved catalytic stability over 2 days was also observed with the redox nanoparticles, highlighting a stabilizing effect of the polymeric architecture. Bioinspired nanoparticles as mediators for bioelectrocatalysis promises to be valuable for future biofuel cells and biosensors. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6SDS of cas: 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.SDS of cas: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Erhart, Theresia; Vergeiner, Stefan; Kreutz, Christoph; Kraeutler, Bernhard; Mueller, Thomas published 《Chlorophyll breakdown in a fern – Discovery of phyllobilin isomers with a rearranged carbon skeleton》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 56602-33-6 The information in the text is summarized as follows:

All structure-based information on chlorophyll (Chl) breakdown in the higher plants relies on studies with angiosperms. Here, the 1st investigation of a fern is reported, revealing a novel type of Chl catabolites (phyllobilins) in leaves of this large division of vascular plants, and providing structural insights into an astounding metabolic process of the higher plants that appears to have played a role even in early phases of plant evolution. The tetrapyrrolic Chl catabolites in the cosmopolitan bracken fern (Pteridium aquilinum) were discovered to be phyllobilin isomers with an unprecedented skeleton, proposed to be the striking result of a rearrangement of a hypothetical phyllobilin precursor. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Recommanded Product: 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Recommanded Product: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lai, Thu Hang; Toussaint, Magali; Teodoro, Rodrigo; Dukic-Stefanovic, Sladjana; Kranz, Mathias; Deuther-Conrad, Winnie; Moldovan, Rares-Petru; Brust, Peter published an article in 2021. The article was titled 《Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor》, and you may find the article in International Journal of Molecular Sciences.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

The adenosine A2A receptor (A2AR) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomog. (PET) is of utmost importance to monitor the receptor expression and occupancy during an A2AR-tailored therapy. Aiming at the development of a PET radiotracer, we herein report the design of a series of novel fluorinated analogs (TOZ1-TOZ7) based on the structure of the A2AR antagonist tozadenant, and the preclin. evaluation of [18F]TOZ1. Autoradiog. proved A2AR-specific in vitro binding of [18F]TOZ1 to striatum of mouse and pig brain. Investigations of the metabolic stability in mice revealed parent fractions of more than 76% and 92% of total activity in plasma and brain samples, resp. Dynamic PET/magnetic resonance imaging (MRI) studies in mice revealed a brain uptake but no A2AR-specific in vivo binding. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics