Category: 4922-98-9

4922-98-9, Adding some certain compound to certain chemical reactions, such as: 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4922-98-9.

Part C; A reaction mixture of compound 14-2 (50 mg, 0.2 mmol) and 3-phenyl-1 H- 1 ,2,4-triazol-5-amine (32 mg, 0.2 mmol) in AcOH (1 mL) was stirred at 160 0C for 20 minutes in microwave. Purification using reverse phase HPLC gave compound 14-3 after lyophilization.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4922-98-9.

Reference:
Patent; SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann; WO2010/56631; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4922-98-9. 4922-98-9

Example 11; Part A; A reaction mixture of 3-phenyl-1 H-1 ,2,4-tpiazol-5-amiotane (160 mg, 1 mmol) and dimethyl but-2-ynediotaoate (123 mul_, 1 mmol) in methanol (2 ml_) was stirred at room temperature for overnight Purification using reverse phase HPLC gave compound 11-1 as a solid after lyophilization HPLC-MS RT= 3 08 mm, mass calculated for formula Ci3H10N4O3270 08, observed LCMS m/z 271 28 (M+H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Phenyl-1H-1,2,4-triazol-3-amine.

Reference:
Patent; SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann; WO2010/56631; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

4922-98-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of the appropriate 1,2,4-triazole 8a-t (1 mmol)in dry pyridine (5 mL) cooled at ?5 ¡ãC was added 3?,4?,5?-trimethoxybenzoylchloride (252 mg, 1.1 mol, 1.1 equiv.) in small portions. For the preparation of compounds 5u and 5v, 3?,4?-dimethoxybenzoylchloride (221 mg, 1.1 mmol, 1.1 equiv.) or 4?-methoxybenzoyl chloride(188 mg, 1.1 mmol, 1.1 equiv.), respectively, were added to derivative 5k. The reaction mixture was kept for 30 min at ?5 ¡ãC and then overnight at room temperature. Pyridine was removed by evaporation under reduced pressure. To the residue was added CH2Cl2, and the organic phase was washed with saturated aq. NaHCO3, water and brine and dried. The reaction mixture was filtered, and the solvent was removed in vacuo. The crude residue was suspended in ethyl ether(15 mL), the resulting suspension stirred for 30 min, filtered and the residue filtered under reduced pressure to furnish the 1-aroyl-3-aryl-5-amino-1H-1,2,4-triazole derivatives 5a-v. Compounds 5a, 5e, 5f and 5hwere characterized by spectroscopic and analytical data, and our datawere in agreement with those previously reported [30]. 5.1.4.1. (5-Amino-3-phenyl-1H-1,2,4-triazol-1-yl) (3,4,5-trimethoxyphenyl)methanone (5a). Synthesized according to method C, derivative 5a wasobtained as a white solid (yield 66percent); mp 225?227 ¡ãC. 1HNMR(d6-DMSO)delta: 3.80 (s, 3H), 3.87 (s, 6H), 7.47 (m, 3H), 7.68 (s, 2H), 7.86 (bs, 2H), 8.03(m, 2H). 13C NMR (d6-DMSO) delta: 55.96 (2C), 60.13, 108.92 (2C), 126.22(2C), 126.42, 128.70 (2C), 130.02, 130.64, 141.60, 152.00 (2C), 159.05,159.40, 166.39. MS (ESI): [M+1]+=355.37. Anal. calcd forC18H18N4O4. C, 61.01; H, 5.12; N, 15.81; found: C, 60.78; H, 5.01; N,15.67.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro; Bioorganic Chemistry; vol. 80; (2018); p. 361 – 374;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4922-98-9. 4922-98-9

6.02.04.37 5-bromo-3-phenyl-lH-(l, 2, 4) triazole 115 mL bromine hydro acid was added to 9.5 g 5-phenyl-2H-(l, 2, 4) triazol-3-ylamine and 12.3 g sodiumnitrite at -5¡ãC. The reaction was warmed to RT and refluxed for 20 min. Then the mixture was cooled and basicfied with sodiumdicarbonate and extracted with ethyl acetate. The organic layer was dried and evaporated to give 11 g of the desired product. Rt: 1.07 min (method B), (M+H)+: 223/225

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Phenyl-1H-1,2,4-triazol-3-amine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WO2013/107761; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics