Category: 39876-84-1

Synthesis of new 1,2,3-triazolo[1,2-a]benzotriazole derivatives or substituted 2,3-benzo-1,3a,6,6a-tetraazapentalenes. II was written by Biagi, Giuliana;Giorgi, Irene;Livi, Oreste;Manera, Clementina;Scartoni, Valerio;Barili, Pier Luigi. And the article was included in Journal of Heterocyclic Chemistry in 1997.Synthetic Route of C8H8N4 The following contents are mentioned in the article:

The synthesis of new 1,2,3-triazolo[1,2-a]benzotriazoles or 2,3-benzo-1,3a,6,6a-tetraazapentalenes is reported. The derivatives were obtained by deoxycyclization reactions of appropriate nitrophenyl-1,2,3-triazole derivatives and by thermal decomposition of appropriate azidophenyl-1,2,3-triazoles. Some attempts to extend these synthetic routes to the preparation of 1,2,4-triazolo[1,2-a]benzotriazoles and 1,2,3-triazolo[1,2-b]-4H-1,2,3-benzotriazines completely failed. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Synthetic Route of C8H8N4).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C8H8N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A catalytic intramolecular nitrene insertion into a copper(I)-N-heterocyclic carbene bond yielding fused nitrogen heterocycles was written by Fauche, Kevin;Nauton, Lionel;Jouffret, Laurent;Cisnetti, Federico;Gautier, Arnaud. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.HPLC of Formula: 39876-84-1 The following contents are mentioned in the article:

N-(2-Azidophenyl)azolium salts were easily prepared and reacted with Cu(I) under conditions allowing the formation of NHC complexes. Under these conditions, the formation of benzimidazo-fused heterocycles occurred under catalytic, efficient and very mild conditions. This reaction is proposed to proceed via dinitrogen elimination and imido/nitrene-NHC cyclization. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1HPLC of Formula: 39876-84-1).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.HPLC of Formula: 39876-84-1

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of heterocyclic compounds. III. Aryl-1,2,4-triazoles was written by Khan, Misbahul Ain;Polya, J. B.. And the article was included in Revista Latinoamericana de Quimica in 1972.Safety of 2-(1,2,4-Triazol-1-yl)aniline The following contents are mentioned in the article:

The aryltriazoles I-III (R = H, o-, p-NO2, o-, m-, p-Ph) were prepared An RC6H4NHNH2 reacted with Me2NCH:NCH:N+Me2 Cl- to give I. RC6H4NH2 condensed with HCONHNHCHO to give II. The Gomberg-Bauchmann arylation reaction of III (R = NH2) gave III (R = Ph, o-NO2C6H4, p-NO2C6H4). This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Safety of 2-(1,2,4-Triazol-1-yl)aniline).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Safety of 2-(1,2,4-Triazol-1-yl)aniline

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A Unified Strategy Towards N-Aryl Heterocycles by a One-Pot Copper-Catalyzed Oxidative C-H Amination of Azoles was written by Subramanian, Parthasarathi;Kaliappan, Krishna P.. And the article was included in European Journal of Organic Chemistry in 2014.Product Details of 39876-84-1 The following contents are mentioned in the article:

An efficient one-pot synthesis of N-aryl-substituted heterocycles, e.g. I (R¹ = H; R¹₂ = CH:CHCH:CH; R² = Ph, 2-pyridyl, 4-methyl-2-pyridyl, 2-naphthyl), by a Cu-catalyzed two-fold C-N bond formation is reported. This strategy involves a Cu^I-catalyzed C-N bond-forming reaction between o-aminoaryl-substituted azoles, e.g. II, and electron-deficient bromoarenes R²Br followed by an intramol. sp² C-H amination. The product I (R¹₂ = CH:CHCH:CH; R² = 6-methyl-2-pyridyl) thus formed has been successfully used as a ligand for the synthesis of a Pd complex. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Product Details of 39876-84-1).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Product Details of 39876-84-1

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An efficient synthesis of 4-Thiocyanato anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H₂O was written by Dass, Reuben;Singleton, Justin D.;Peterson, Matt A.. And the article was included in Tetrahedron Letters in 2022.SDS of cas: 39876-84-1 The following contents are mentioned in the article:

Treatment of a variety of 2(3)-mono-substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.2 equiv) in DMSO:H₂O (9:1) at 70°C gave the corresponding 4-thiocyanato-2(3)-substituted anilines ArSC≡N [Ar = 4-OH-3-MeC₆H₃, 4-NH₂-3-BrC₆H₃, 3-isoquinolyl, etc.] in excellent isolated yields (60-99%; ave. yield for all anilines = 90%). The reaction worked well for substrates with 2-halo, 2-alkoxy, 2-aryloxy, 2-alkyl, 2-dialkylamino, 2-N-sulfonylamino, 2-alkyn-1-yl, 2-cyano, 2-acyl, 2-sulfonyl, and 2-heteroaryl substitution. 3-Substituted, 3,5- or 2,6-disubstituted anilines and substituted phenols were also well tolerated. 4-Substituted anilines gave the corresponding 2-aminobenzothiazole products ArSC≡N, whereas 4-, 5-, 6-, or 7-substituted indoles were not reactive. Regioselective thiocyanation of 2-quinoline, 3-amino-1-methylpyrazole, 2-amino-4-phenylthiazole, and 2-phenylimidazo[1,2-a] pyridine was achieved in 93-99% yield, thus demonstrating the broad-substrate scope for this thiocyanation reaction. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1SDS of cas: 39876-84-1).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.SDS of cas: 39876-84-1

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists was written by Miah, Afjal H.;Copley, Royston C. B.;O’Flynn, Daniel;Percy, Jonathan M.;Procopiou, Panayiotis A.. And the article was included in Organic & Biomolecular Chemistry in 2014.Category: triazoles The following contents are mentioned in the article:

A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesized and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimization program. X-ray diffraction studies were used to identify the pyrazole ring as a moiety that could bring about intramol. hydrogen bonding with the sulfonamide NH and provide a clip or orthogonal conformation that was believed to be the preferred active conformation. Replacement of the core Ph ring with a pyridine, and replacement of the 2,3-dichlorobenzenesulfonamide with 5-chlorothiophenesulfonamide provided compound I which has excellent physicochem. properties and represents a good starting point for a lead optimization program. Electronic structure calculations indicated that the preference for the clip or orthogonal conformation found in the small mol. crystal structures of II and III was in agreement with the order of potency in the biol. assay. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Category: triazoles).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of Highly Functionalized Polycyclic Quinoxaline Derivatives Using Visible-Light Photoredox Catalysis was written by He, Zhi;Bae, Minwoo;Wu, Jie;Jamison, Timothy F.. And the article was included in Angewandte Chemie, International Edition in 2014.Application In Synthesis of 2-(1,2,4-Triazol-1-yl)aniline The following contents are mentioned in the article:

A mild and facile method for preparing highly functionalized pyrrolo[1,2-a]quinoxalines and other nitrogen-rich heterocycles, each containing a quinoxaline core or an analog thereof, has been developed. The novel method features a visible-light-induced decarboxylation and radical coupling of ortho-substituted aryl isocyanides and radicals generated from phenyliodine(III) dicarboxylate reagents and exhibits excellent functional group compatibility. A wide range of quinoxaline heterocycles have been prepared Finally, a telescoped preparation of these polycyclic compounds by integration of the in-line isocyanide formation and photochem. cyclization has been established in a three-step continuous-flow system. The title compounds thus formed included derivatives of imidazo[1,2-a]quinoxaline, pyrrolo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, benzimidazo[1,2-a]quinoxaline, pyrazolo[1,5-a]quinoxaline, [1,2,4]triazolo[1,5-a]quinoxaline, [1,2,3]triazolo[1,5-a]quinoxaline, tetrazolo[1,5-a]quinoxaline, pyrido[3,2-e][1,2,4]triazolo[1,5a]pyrazine. Under optimized conditions the synthesis of the target compounds was achieved using tris[2-(2-pyridinyl-κN)phenyl-κC]iridium [i.e., fac-Ir(ppy)₃, photoredox catalyst] as a catalyst. Starting materials included bis(benzoato-κO)phenyliodine and bis(acetato-κO)phenyliodine. Key intermediates included isocyanides (isonitriles), such as 1-(2-isocyanophenyl)pyrrole, 1-(2-isocyanophenyl)-1H-indole and similar azole derivatives Reactants included carboxylic acids, such as benzenepropanoic acid, cyclohexaneacetic acid, pentanedioic acid 1-Me ester, (4S)-2,2-dimethyl-5-oxo-1,3-dioxolane-4-acetic acid, 10-undecenoic acid (fatty acid), 5-pentynoic acid. Amino acids included N-[(1,1-dimethylethoxy)carbonyl]-β-alanine, N-[(1,1-dimethylethoxy)carbonyl]-L-aspartic acid ester., N-[(1,1-dimethylethoxy)carbonyl]-L-glutamic acid ester. (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid (cholalic acid) and (3α,5β)-3-(hydroxy)cholan-24-oic acid (lithocholic acid, bile acid) were also used as reactants. This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Application In Synthesis of 2-(1,2,4-Triazol-1-yl)aniline).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Application In Synthesis of 2-(1,2,4-Triazol-1-yl)aniline

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics