Category: 288-36-8

《A fast and simple SPE-LC-MS/MS procedure for extraction and quantitative analysis of 1,2,4-triazole, N,N-dimethylsulfamide, and other small polar organic compounds in groundwater》 was written by Bollmann, Ulla E.; Badawi, Nora. Application of 288-36-8This research focused ontriazole dimethylsulfamide organic compound groundwater; ENVI-Carb; Hypercarb; LC-MS/MS; PMOCs; SPE; Solid phase extraction. The article conveys some information:

Small polar organic pollutants have been discovered to be great threats to the groundwater, as they often are highly mobile and persistent in the environment. 1,2,4-Triazole and N,N-dimethylsulfamide, two well-known examples of small polar compounds, are frequent pollutants of upper groundwater. Both are degradation products of several fungicides commonly or previously used in agriculture, but also in wood-preserving paints. A common trait in the anal. of these small polar compounds is the lack of sufficient pre-concentration methods to lower the limit of detection and enable quant. anal. at nano-scale concentrations To date, they are analyzed only by direct injection in HPLC-MS/MS, with detection limits just below the European threshold value for pesticides in groundwater of 0.1μg/L. Based on a comprehensive method development, a solid phase extraction method was developed. As known LC methods for anal. of 1,2,4-triazole are based on Thermo Fisher’s Hypercarb column, emphasis was placed on testing various carbon-based materials. The final, thoroughly validated extraction protocol is based on Supelco’s ENVI-Carb Plus cartridges. With extraction recoveries close to 100% for 1,2,4-triazole and N,N-dimethylsulfamide and quantification limits of around 0.003μg/L, the method enables extraction and quantification of polar pollutants at nano-scale concentration from groundwater samples. In addition, the method is very promising to be used for other small polar pollutants. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,3-TriazoleIn 2021 ,《1,2,3-Triazole hybrids with anti-HIV-1 activity》 appeared in Archiv der Pharmazie (Weinheim, Germany). The author of the article were Feng, Lian-Shun; Zheng, Man-Jie; Zhao, Feng; Liu, Duan. The article conveys some information:

A review. The human immunodeficiency virus type 1 (HIV-1) is the major etiol. agent responsible for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease and remains one of the most prevalent problems at present. Currently, combined antiretroviral therapy is the primary modality for the treatment and management of HIV/AIDS, but the long-term use can result in major drawbacks such as the development of multidrug-resistant viruses and multiple side effects. 1,2,3-Triazole is the common framework in the development of new drugs, and its derivatives have the potential to inhibit various HIV-1 enzymes such as reverse transcriptase, integrase, and protease, consequently possessing a potential anti-HIV-1 activity. This review covers the recent advances regarding the 1,2,3-triazole hybrids with potential anti-HIV-1 activity; it focuses on the chem. structures, structure-activity relationship, and mechanisms of action, covering articles published from 2010 to 2020. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of 1H-1,2,3-TriazoleIn 2021 ,《Characterizing and Contrasting Structural Proton Transport Mechanisms in Azole Hydrogen Bond Networks Using Ab Initio Molecular Dynamics》 appeared in Journal of Physical Chemistry Letters. The author of the article were Atsango, Austin O.; Tuckerman, Mark E.; Markland, Thomas E.. The article conveys some information:

Imidazole and 1,2,3-triazole are promising hydrogen-bonded heterocycles that conduct protons via a structural mechanism and whose derivatives are present in systems ranging from biol. proton channels to proton exchange membrane fuel cells. Here, the authors leverage multiple time-stepping to perform ab initio mol. dynamics of imidazole and 1,2,3-triazole at the nanosecond time scale. Despite the close structural similarities of these compounds, their proton diffusion constants vary by over an order of magnitude. The authors’ simulations reveal the reasons for these differences in diffusion constants, which range from the degree of hydrogen-bonded chain linearity to the effect of the central nitrogen atom in 1,2,3-triazole on proton transport. In particular, the authors uncover evidence of two “”blocking”” mechanisms in 1,2,3-triazole, where covalent and hydrogen bonds formed by the central nitrogen atom limit the mobility of protons. The authors’ simulations thus provide insights into the origins of the exptl. observed 10-fold difference in proton conductivity After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Quality Control of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Quality Control of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,International Journal of Molecular Sciences included an article by Harej, Anja; Macan, Andrijana Mescic; Stepanic, Visnja; Klobucar, Marko; Pavelic, Kresimir; Pavelic, Sandra Kraljevic; Raic-Malic, Silvana. Synthetic Route of C2H3N3. The article was titled 《The antioxidant and antiproliferative activities of 1,2,3-triazolyl-L-ascorbic acid derivatives》. The information in the text is summarized as follows:

The novel 4-substituted 1,2,3-triazole L-ascorbic acid (L-ASA) conjugates with hydroxyethylene spacer as well as their conformationally restricted 4,5-unsaturated analogs were synthesized as potential antioxidant and antiproliferative agents. An evaluation of the antioxidant activity of novel compounds showed that the majority of the 4,5-unsaturated L-ASA derivatives showed a better antioxidant activity compared to their saturated counterparts. m-Hydroxyphenyl (7j), p-pentylphenyl (7k) and 2-hydroxyethyl (7q) substituted 4,5-unsaturated 1,2,3-triazole L-ASA derivatives exhibited very efficient and rapid (within 5 min) 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging activity (7j, 7k: IC50 = 0.06 mM; 7q: IC50 = 0.07 mM). In vitro scavenging activity data were supported by in silico quantum-chem. modeling. Thermodn. parameters for hydrogen-atom transfer and electron-transfer radical scavenging pathways of anions deprotonated at C2-OH or C3-OH groups of L-ASA fragments were calculated The structure activity anal. (SAR) through principal component anal. indicated radical scavenging activity by the participation of OH group with favorable reaction parameters: the C3-OH group of saturated C4-C5(OH) derivatives and the C2-OH group of their unsaturated C4 = C5 analogs. The antiproliferative evaluation showed that p-bromophenyl (4e: IC50 = 6.72 μM) and p-pentylphenyl-substituted 1,2,3-triazole L-ASA conjugate (4k: IC50 = 26.91 μM) had a selective cytotoxic effect on breast adenocarcinoma MCF-7 cells. Moreover, compound 4e did not inhibit the growth of foreskin fibroblasts (IC50 > 100 μM). In MCF-7 cells treated with 4e, a significant increase of hydroxylated hypoxia-inducible transcription factor 1 alpha (HIF-1α) expression and decreased expression of nitric oxide synthase 2 (NOS2) were observed, suggesting the involvement of 4e in the HIF-1α signaling pathway for its strong growth-inhibition effect on MCF-7 cells. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, thermal properties, conductivity and lifetime of proton conductors based on nanocrystalline cellulose surface-functionalized with triazole and imidazole》 was written by Tritt-Goc, J.; Lindner, L.; Bielejewski, M.; Markiewicz, E.; Pankiewicz, R.. Synthetic Route of C2H3N3This research focused ontriazole imidazole functionalized cellulose nanocrystal proton exchange membrane. The article conveys some information:

A new proton conductor based on 1H-1,2,3-triazole doped nanocrystalline cellulose (2.66 CNC-Tri) has been synthesized for possible use as an electrolyte in proton exchange membrane (PEM) cells. The physicochem. properties of 2.66 CNC-Tri were determined and compared with those of imidazole-doped nanocrystalline (1.17 CNC-Im) and pure nanocrystalline cellulose (CNC). The composites were obtained in the form of a film and their synthesis proceeded under vacuum. The maximum conductivity of 2.66 CNC-Tri was measured to be 0.1 x 10-4 S/m at 175°C and that of 1.17 CNC-Im to be 1.6 x 10-2 S/m at 155°C, in the anhydrous state. The composite 2.66 CNC-Tri, compared to 1.17 CNC-Im, has much better thermal properties manifested as stability of the matrix and durability of the heterocyclic mol. The lifetimes of 2.66 CNC-Tri fulfills the requirements of the U.S. Department of Energy for the min. lifetimes of a PEM based fuel cell for cars. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Taming Ambident Triazole Anions: Regioselective Ion Pairing Catalyzes Direct N-Alkylation with Atypical Regioselectivity》 was written by Dale, Harvey J. A.; Hodges, George R.; Lloyd-Jones, Guy C.. COA of Formula: C2H3N3This research focused ontriazole regioselective alkylation organocatalysis ion pairing. The article conveys some information:

Controlling the regioselectivity of ambident nucleophiles toward alkylating agents is a fundamental problem in heterocyclic chem. Unsubstituted triazoles are particularly challenging, often requiring inefficient stepwise protection-deprotection strategies and prefunctionalization protocols. Herein we report on the alkylation of archetypal ambident 1,2,4-triazole, 1,2,3-triazole, and their anions, analyzed by in situ 1H/19F NMR, kinetic modeling, diffusion-ordered NMR spectroscopy, X-ray crystallog., highly correlated coupled-cluster computations [CCSD(T)-F12, DF-LCCSD(T)-F12, DLPNO-CCSD(T)], and Marcus theory. The resulting mechanistic insights allow design of an organocatalytic methodol. for ambident control in the direct N-alkylation of unsubstituted triazole anions. Amidinium and guanidinium receptors are shown to act as strongly coordinating phase-transfer organocatalysts, shuttling triazolate anions into solution The intimate ion pairs formed in solution retain the reactivity of liberated triazole anions but, by virtue of highly regioselective ion pairing, exhibit alkylation selectivities that are completely inverted (1,2,4-triazole) or substantially enhanced (1,2,3-triazole) compared to the parent anions. The methodol. allows direct access to 4-alkyl-1,2,4-triazoles (rr up to 94:6) and 1-alkyl-1,2,3-triazoles (rr up to 99:1) in one step. Regioselective ion pairing acts in effect as a noncovalent in situ protection mechanism, a concept that may have broader application in the control of ambident systems. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Jiu, Alexander Y.; Slocumb, Hannah S.; Yeung, Charles S.; Yang, Xiao-Hui; Dong, Vy M. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Addition of Pyrazoles to Dienes》.Application of 288-36-8 The article contains the following contents:

We report the first enantioselective addition of pyrazoles to 1,3-dienes [e.g., 1H-pyrazole + (E)-1-phenyl-1,3-butadiene → I (91%, 96:4 er)]. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lin, Yu-Diao; Zhu, Zeng-Kui; Ge, Rui; Yu, Hao; Li, Zhong; Sun, Cai; Sun, Yan-Qiong; Li, Xin-Xiong; Zheng, Shou-Tian published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Proton conductive polyoxoniobate frameworks constructed from nanoscale {Nb68O200} cages》.Electric Literature of C2H3N3 The article contains the following contents:

Nanoscale {Nb68O200} cages have been successfully employed as flexible and stable secondary building units to combine with bridging copper-amine complexes to construct two proton conductive polyoxoniobate frameworks, demonstrating a promising strategy for making new porous materials. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Environmental Science and Pollution Research included an article by Pelizaro, Bruno Ivo; Braga, Felipe Camargo; Crispim, Bruno do Amaral; de Barros, Luiz Guilherme Maiolino Lacerda; Pessatto, Lucas Roberto; Oliveira, Edwin Jose Torres; Vani, Juliana Miron; de Souza, Antonio Pancracio; Grisolia, Alexeia Barufatti; Antoniolli-Silva, Andreia Conceicao Milan Brochado; de Lima, Denis Pires; dos Santos Jaques, Jeandre Augusto; Beatriz, Adilson; Oliveira, Rodrigo Juliano. Quality Control of 1H-1,2,3-Triazole. The article was titled 《Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models》. The information in the text is summarized as follows:

The amphyphylic triazoanilines recently synthesized 1-(4-(3-aminophenyl)-1H-1,2,3- triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (1) and 1-(4-(4-aminophenyl)-1H- 1,2,3-triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (2), synthesized from cardanol and glycerol, have photophys. properties which allow their use in the development of fluorescent biomarkers with applicability in the biodiesel quality control. Based on this, the present research evaluated the toxic effects of both compounds in different biol. models through the investigation of survival and mortality percentages as a measure of acute toxicity on Daphnia similis and Oreochromis niloticus, larvicidal assay against Aedes aegypti, and cytotoxic activity on mammary cells. Results demonstrate that these triazoanilines 1 and 2 have shown low acute toxicity to the biol. models investigated in this study up to the following concentrations: 4.0 mg L-1 (D. similis), 4.0 mg L-1 (A. aegypti larvae), 1.0 mg L-1 (O. niloticus), and 1.0 mg mL-1 (mammary cells). This fact suggests the potential for safe use of compounds 1 and 2 as fluorescent markers for the monitoring of biodiesel quality, even in the case of environmental exposure. Besides all of that, the reuse of cardanol and glycerol, both industrial wastes, favors the maintenance of environmental health and is in agreement with the assumptions of green chem. The experimental process involved the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Quality Control of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Quality Control of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Diamine-mediated N2-selective β-selenoalkylation of triazoles with alkenes》 was written by Zhu, Li-Li; Tian, Lifang; Cai, Bin; Liu, Guanglu; Zhang, Hui; Wang, Yahui. Computed Properties of C2H3N3This research focused ontriazole derivative regioselective preparation; alkene triazole regioselective selenoalkylation diamine. The article conveys some information:

A N2-selective β-selenoalkylation of 1,2,3-triazoles with alkenes mediated by diamines has been developed. The reaction proceeds presumably via the interaction of diamines with both the triazole moiety and selenium/alkene complex to construct a U-shaped reaction intermediate. This activation mode will block the N1 position on triazoles and thus favor the N2-selective selenoamination. This stereospecific anti-addition method enables an efficient N2-selective β-selenoalkylation of 1,2,3-triazoles under mild and open-air conditions and might find applications in the synthesis of biol. active mols. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Computed Properties of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Computed Properties of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics