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Cui, Menghan’s team published research in Journal of Organic Chemistry in 2022 | CAS: 288-36-8

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Category: triazoles

In 2022,Cui, Menghan; Wang, Rong; Yang, Qing; Kuang, Chunxiang published an article in Journal of Organic Chemistry. The title of the article was 《Copper-Promoted One-Pot Sandmeyer-Type Reaction for the Synthesis of N-Aryltriazoles》.Category: triazoles The author mentioned the following in the article:

Herein, the copper-catalyzed one-pot Sandmeyer-type reaction of aromatic amines with triazoles to afford N-aryl-1,2,3-triazoles such as I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R = H, 4-Me, 3-Me, 4-C(O)OMe, 4-Ph; X1 = N, CH; X2 = N, CH;] was reported. Diazonium salts, formed from aromatic amines and tert-Bu nitrite in the presence of fluoroboric acid, reacted with triazoles in a copper-catalyzed Sandmeyer-type reaction. The reaction proceeded under mild conditions to afford N-aryltriazoles such as I in moderate to good yields. This method was amenable to a wide range of aromatic amines and triazoles and showed diverse functional group tolerance. Inhibition of the reaction upon the addition of free radical scavengers suggested a radical pathway, in which the aryl radical, copper, and triazole formed a complex that underwent reductive elimination to gave aryltriazole compounds such as I; this was consistent with the mechanism underlying the Sandmeyer reaction. Thus, a new effective strategy for the construction of C-N bonds via Sandmeyer-type reactions and a valuable alternative approach for the synthesis of aryltriazole derivs such as I was demonstrated. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Huang, Yulin’s team published research in Journal of Chemical Research in 2019 | CAS: 288-36-8

In 2019,Journal of Chemical Research included an article by Huang, Yulin; Lei, Jiaying; Fu, Xinliang; Xie, Wenlin; Li, Xiaofang. Category: triazoles. The article was titled 《Synthesis of 1,2,3-triazole-substituted 6,7-dihydroindolizin-8(5H)-one derivatives mediated by Selectfluor》. The information in the text is summarized as follows:

The 1,2,3-triazole and 1H-1,2,3-benzotriazole-substituted 6,7-dihydroindolizin-8(5H)-one derivatives I [R = 1-triazolyl, 1-benzotriazolyl; Ar = Ph, 4-ClC6H4, 4-MeC6H4,etc.] were synthesized by the reaction of (E)-7-(arylmethylidene)-6,7-dihydroindolizin-8(5H)-ones with 1,2,3-triazole and 1H-1,2,3-benzotriazole in the presence of selectfluor in moderate yield. The structures of all the products were characterized thoroughly by NMR, IR, and high-resolution mass spectrometry together with X-ray crystallog. anal. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles) was used in this study.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kuzevanova, Iryna S.’s team published research in Dalton Transactions in 2021 | CAS: 288-36-8

《Spin crossover in iron(II) Hofmann clathrates analogues with 1,2,3-triazole》 was written by Kuzevanova, Iryna S.; Kucheriv, Olesia I.; Hiiuk, Volodymyr M.; Naumova, Dina D.; Shova, Sergiu; Shylin, Sergii I.; Kotsyubynsky, Volodymyr O.; Rotaru, Aurelian; Fritsky, Igor O.; Gural’skiy, Il’ya A.. HPLC of Formula: 288-36-8This research focused ontriazolyl iron palladium platinum cyanometallate preparation crystal mol structure; spin crossover iron Hofmann clathrate analog triazolyl iron clathrate. The article conveys some information:

Hofmann-like cyanometallic complexes represent one of the biggest and well-known classes of FeII spin-crossover compounds In this paper, authors report on the first FeII Hofmann clathrate analogs with unsubstituted 1,2,3-triazole, which exhibit temperature induced spin transition. Two new coordination polymers with the general formula [FeII(1,2,3-triazole)2MII(CN)4] (M = Pt, Pd) undergo abrupt hysteretic spin crossover in the range of 190-225 K as revealed by magnetic susceptibility measurements. Two compounds are isostructural and are built of infinite cyanometallic layers which are supported by 1,2,3-triazole ligands. The thermal hysteresis loop is very stable at different scan rates from 0.5 to 10 K min-1. The compounds display strong thermochromic effect, changing their color from pink in the low-spin state to white in the high-spin state. Their findings show that 1,2,3-triazole is suitable for elaboration of spin-crossover Hofmann clathrate analogs, and its use instead of more classical azines can advantageously expand this family of complexes. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Singh, Rakesh’s team published research in Asian Journal of Chemistry in 2021 | CAS: 288-36-8

Recommanded Product: 288-36-8In 2021 ,《1,2,3-triazoles: lead molecules for promising drugs: a review》 appeared in Asian Journal of Chemistry. The author of the article were Singh, Rakesh; Kaur, Harpreet; Gupta, Pankaj. The article conveys some information:

A review. A large number of heterocyclic compounds with five membered rings as the parent nucleus such as tetrazoles, imidazoles, triazoles, oxadiazoles, thiadiazoles, thiazoles, etc. have been studied extensively owing to their fascinating biol. properties like anticancer, antifungal, antimicrobial, antitumor, anticonvulsant, antiviral, etc. 1,2,3-Triazoles are important class of five-membered biol. active heterocyclic compounds as they exhibit wide range of pharmacol. activities. Triazoles are of two types viz. 1,2,3-triazole and 1,2,4-triazole. These compounds have drawn great attention from chemists and biologists since their discovery. In recent years, triazoles has emerged as an interesting field in drug design for many researchers due to their enormous pharmacol. scope. The present review aims to sum up the medicinal significance of 1,2,3-triazoles as one of the most significant structures for the development of drug mols. like anticancer, antibacterial, HIV protease inhibitors, antifungal, anti-inflammatory (COX-1/COX-2 inhibitors), antiprotozoal, anticonvulsant, antioxidant and others, which are under clin. trials. Various benzyl and benzyl-halide functionalized 1,2,3-triazole derivatives like rufinamide, mubritinib (TAK-165) and suvorexant showing excellent biol. activities have been used as medicine. In present review, more stress has been laid on the major developments in the therapeutic aspects of triazole pharmacophore for the last two decades. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 288-36-8)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kumar Ghosh, Asim’s team published research in Journal of Organic Chemistry in 2022 | CAS: 288-36-8

In 2022,Kumar Ghosh, Asim; Neogi, Sukanya; Das, Krishna Kanta; Hajra, Alakananda published an article in Journal of Organic Chemistry. The title of the article was 《Organocatalytic Oxidative C-H Amination of Aldehyde Hydrazones with Azoles at Ambient Temperature》.Safety of 1H-1,2,3-Triazole The author mentioned the following in the article:

An efficient, metal-free, and direct oxidative amination of aldehyde-derived hydrazones R1CH=N-N(CH2)2X(CH2)2- (R1 = Ph, 2-bromo-5-chlorophenyl, naphthalen-1-yl, 2-methylphenyl, etc.; X = O, CH2) with azoles e.g., I has been developed using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an organocatalyst under ambient temperature This protocol provides a wide range of aminated hydrazone derivatives II (R2 = 3,5-dimethyl-1H-pyrazol-1-yl, 2H-indazol-2-yl, 4-phenyl-1H-1,2,3-triazol-1-yl, etc.) in a step and atom economical fashion. The reaction possibly follows a radical mechanism.1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole) was used in this study.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Mingyue’s team published research in Inorganic Chemistry Communications in 2021 | CAS: 288-36-8

Li, Mingyue; Fu, Yaomei; You, Siqi; Yang, Yu; Qin, Chao; Zhao, Liang; Su, Zhongmin published an article in 2021. The article was titled 《Hexanuclear nickel-based [P4Mo11O50] with photocatalytic reduction of CO2 activity》, and you may find the article in Inorganic Chemistry Communications.Related Products of 288-36-8 The information in the text is summarized as follows:

A new polyoxometalate based organic-inorganic hybrid [Ni6(trz)2(Htrz)13][H4P4Mo11O50]·7H2O (1), constructed from a hexanuclear [Ni6(trz)2(Htrz)13] building block and a new polyoxometalate [H4P4Mo11O50] cluster, was synthesized under a hydrothermal condition. In this 3D structure, each [Ni6(trz)2(Htrz)13] secondary building unit (SBU) connects with four neighbored [Ni6(trz)2(Htrz)13] and four [H4P4Mo11O50] clusters, forming an eight-connected node. While each [H4P4Mo11O50] cluster bridges four [Ni6(trz)2(Htrz)13] SBUs as a four-connected node. So the 3D framework of 1 can be simplified to a binodal (4,8)-connected gsp2 topol. with point symbol [44·62][416·612]. The photocatalytic reduction of CO2 under visible light reveals that the highest yield of CO was 689.86μmol g-1 when 1 is used as catalyst, Ru(bpy)3Cl2 as a photosensitizer and TEOA as a sacrificial agent. The mechanism of the photoreduction of CO2 is confirmed by Mott-Schottky, photocurrent, and fluorescence quenching experiments This research provides a new strategy for the design of cheap and efficient POM-based photocatalysts. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yan, Wei’s team published research in Pesticide Biochemistry and Physiology in 2019 | CAS: 288-36-8

In 2019,Pesticide Biochemistry and Physiology included an article by Yan, Wei; Wang, Xing; Li, Ke; Li, Tian-Xi; Wang, Jia-Jie; Yao, Kai-Cheng; Cao, Ling-Ling; Zhao, Shuang-Shuang; Ye, Yong-Hao. Category: triazoles. The article was titled 《Design, synthesis, and antifungal activity of carboxamide derivatives possessing 1,2,3-triazole as potential succinate dehydrogenase inhibitors》. The information in the text is summarized as follows:

Succinate dehydrogenase (SDH) is demonstrably one of the most important mol. targets in development of new fungicide. In our continuous efforts to discover novel SDH inhibitors, forty-two carboxamide derivatives containing 1,2,3-triazole ring were designed and synthesized, which were precisely characterized by 1H NMR, ESI-MS, elemental anal. and X-ray single-crystal diffraction. The compounds were screened for antifungal activities against phytopathogenic fungi by mycelia growth inhibition assay in vitro. Compound A3-3 exhibited significant antifungal activity against Sclerotinia sclerotiorum, Botrytis cinerea, Rhizoctonia cerealis and Gaeumannomyces graminsis with EC50 values of 1.08, 8.75, 1.67 and 5.30μg/mL, resp., comparable to those of com. SDHI boscalid. In vivo testing demonstrated that A3-3 was effective for suppressing rape sclerotinia rot, cucumber gray mold and wheat powdery mildew caused by S. sclerotiorum, B. cinerea and Blumeria graminis at a dosage of 200μg/mL. Inhibition activities against SDH test proved the designed analogs were effective in the enzyme level. The mol. docking simulation revealed that A3-3 interacted with ARG43, TYR58 and TRP173 of the SDH through hydrogen bond and pi-pi interaction, which could explain the probable mechanism of action between the inhibitor and target protein.1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles) was used in this study.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Brehm, Martin’s team published research in Journal of Physical Chemistry B in 2019 | CAS: 288-36-8

《Triazolium-Based Ionic Liquids: A Novel Class of Cellulose Solvents》 was written by Brehm, Martin; Pulst, Martin; Kressler, Joerg; Sebastiani, Daniel. Safety of 1H-1,2,3-TriazoleThis research focused ontriazolium ionic liquid cellulose solvent solubility synthesis MD simulation. The article conveys some information:

We present first results on triazolium-based ionic liquids (ILs) as a novel class of nonderivatizing solvents for cellulose. Despite their chem. similarity to imidazolium cations, the 1,2,3-triazolium cation lacks the isolated ring proton, leading to reduced formation of N-heterocyclic carbenes (NHCs) and therefore to lower reactivity and less unwanted side reactions. We synthesized six ILs based on 1,2,3-triazolium and 1,2,4-triazolium cations. The acetates are room-temperature ionic liquids and dissolve a similar amount of cellulose as the corresponding imidazolium salt. From NMR spectroscopy of the solution, we rule out polymer degradation The cellulose solubility rises with increasing anion basicity, while being almost independent of the cation. We perform mol. dynamics simulations and compute enthalpies of solvation, which quant. fit the exptl. solubilities. Trajectory anal. reveals strong hydrogen bonds between acetate anions and cellulose hydroxyl groups, while the cations do not form strong hydrogen bonds with cellulose. Thus, the simulations provide an atomistic explanation of our exptl. observations. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kan, Liang’s team published research in ACS Applied Materials & Interfaces in 2020 | CAS: 288-36-8

《Highly Selective Separation of C3H8 and C2H2 from CH4 within Two Water-Stable Zn5 Cluster-Based Metal-Organic Frameworks》 was written by Kan, Liang; Li, Guanghua; Liu, Yunling. HPLC of Formula: 288-36-8This research focused ontriazole zinc triazolediyldiisophthalate terphenyltetracarboxylate metal organic framework preparation structure; crystal structure triazole zinc triazolediyldiisophthalate terphenyltetracarboxylate MOF; propane acetylene methane gas separation triazole zinc triazolediyldiisophthalate terphenyltetracarboxylate; JLU MOF66 MOF67 preparation crystal mol structure gas separation; acetylene; gas separation; metal−organic frameworks; propane; water stability. The article conveys some information:

Adopting the mixed ligands approach, two water-stable Zn5 cluster-based MOFs, [Zn10(TZ)12(TADIPA)2(DMF)4]·DMF·6H2O (JLU-MOF66) and [Zn10(TZ)12(TPTA)2(DMA)2]·2DMA·4H2O (JLU-MOF67), have been constructed (H4TADIPA = 5,5′-(1H-1,2,4-triazole-3,5-diyl)diisophthalic acid, H4TPTA = [1,1′:3′,1”-terphenyl]-3,3”,5,5”-tetracarboxylic acid, and HTZ = 1H-[1,2,3]triazole). Both compounds with [Zn5(TZ)6] clusters exhibit extraordinary stability (pH = 2-11) and selectivity of C3H8/CH4 (308 for JLU-MOF66, and 287 for JLU-MOF67). Compared to JLU-MOF67, JLU-MOF66 with functional groups exhibits higher CO2 and C2H2 uptake capacity and excellent selective separation for C2H2/CH4 (86, 1:1). Such high separation and chem. stability render them as promising materials for industrial applications. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Andreeva, Anastasia B.’s team published research in Chemistry of Materials in 2021 | CAS: 288-36-8

Andreeva, Anastasia B.; Le, Khoa N.; Kadota, Kentaro; Horike, Satoshi; Hendon, Christopher H.; Brozek, Carl K. published their research in Chemistry of Materials in 2021. The article was titled 《Cooperativity and Metal-Linker Dynamics in Spin Crossover Framework Fe(1,2,3-triazolate)2》.COA of Formula: C2H3N3 The article contains the following contents:

Cooperative interactions are responsible for the useful properties of spin crossover (SCO) materials-large hysteresis windows, critical temperatures near room temperature, and abrupt transitions-with hybrid framework materials exhibiting the greatest cooperativity and hysteresis of all SCO systems. However, little is known about the chem. origin of cooperativity in frameworks. Here, the authors present a combined exptl.-computational approach for identifying the origin of cooperativity in the metal-organic framework (MOF) Fe(1,2,3-triazolate)2 (Fe(TA)2), which exhibits the largest known hysteresis window of all SCO materials and unusually high transition temperatures, as a roadmap for understanding the manipulation of SCO behavior in general. Variable-temperature vibrational spectroscopy provides evidence that soft modes associated with dynamic metal-linker bonding trigger the cooperative SCO transition. Thermodn. anal. also confirms a cooperativity magnitude much larger than those of other SCO systems, while electron d. calculations of Fe(TA)2 support previous theor. predictions that large cooperativity arises in materials where SCO produces considerable differences in metal-ligand bond polarities between different spin states. Taken together, this combined exptl.-computational study provides a microscopic basis for understanding cooperative magnetism and highlights the important role of dynamic bonding in the functional behavior of framework materials. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics