Category: 288-36-8

Singh, Amrit; Singh, Amritpal; Amanjot; Singh, Kulvinder; Singh, Gurjaspreet; Saroa, Amandeep published their research in Structural Chemistry in 2021. The article was titled 《Role of non-conventional hydrogen bonding in controlling regioselectivity for nucleophilic aromatic substitution of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers: a computational studies》.Electric Literature of C2H3N3 The article contains the following contents:

Abstract: The nucleophilic aromatic substitution reactions of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers, i.e., 1H-1,2,3-triazole and 2H-1,2,3-triazole, have been investigated theor. using DFT/B3LYP calculations employing 6-31G(d,p) basis set in gas phase as well as in solvent phase. The computational studies have supported the formation of transition states via one-step concerted mechanism for the nucleophilic aromatic displacement of nitro groups with 1,2,3-triazoles rather than intermediate formation via two-step addition-elimination mechanism. The amination of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers have revealed regioselectivity of peri-attack despite sterically favorable para-attack. The regioselectivity is attributed to the stabilization of the transition state through intra-mol. hydrogen bond C-H···O=C. This work presents the role of C-H bond as an effective hydrogen bond donor. The mol. interactions through hydrogen bonding have been investigated using AIM method. This work shall result in the synthesis of new regioselective 1,2,3-triazole-derived phthalimide compounds possessing potential biol. candidature. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Evaluation of N-binding through N1, N2 or N3 of 4-R-1,2,3-Triazolate to [CuCO]+ Complexes》 was written by Franco, Mauricio P.; Carvalho, Beatriz B.; Ribeiro, Marcos A.; Spada, Rene F. K.. Electric Literature of C2H3N3This research focused ontriazole copper complex isomer substituent effect. The article conveys some information:

We computationally investigated eight 4-R-1,2,3-triazolates and their three possible N-binding modes. Optimization of the pre-ligands to verify NPA charges were done with M06-2X/def2-TZVPP. The complexes with [CuCO]+ were optimized with M06 L/def2-TZVPP and the electronic energies were improved with DLPNO-CCSD(T)/cc-pVTZ. Our calculations with pre-ligands indicated the NPA charge of N2 as less neg. than N1 and N3 by at least ∼0.100 e. Taking into account the complexes energies and vibrations, coordination via N2 is the most stable among all three nitrogens in gas-phase by at least, 8 kJ/mol and the vibrational anal. of the νCO indicates linkage isomer N2 as the best electron d. donor among the three linkage isomers. The results exhibit a fine-tuning of ligand donation properties that can be achieved by selecting different R groups in 4-R-1,2,3-triazoles. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Mokariya, Jaydeep A.; Kalola, Anirudhdha G.; Prasad, Pratibha; Patel, Manish P. published an article in Molecular Diversity. The title of the article was 《Simultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation》.Safety of 1H-1,2,3-Triazole The author mentioned the following in the article:

An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindoles, chloroacetic acid/ester and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives I [R = OH, OEt, Ph, etc.; R1 = H, Me] aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time was described. Further, acid derivatives I [R = OH; R1 = H, Me] were subjected to acid-amine coupling reaction with secondary amines in the presence of HATU to afford triazoles II [R2 = 4-methylpiperidin-1-yl, 2-morpholino, 1,2,3-triazol-1-yl, etc.]. The perspective of this protocol was to get rid of the hectic preparation and handling of organic azide which are generated in situ. Consequently, this protocol blossomed the click process by making it environment benign, user-friendly, safe and clean technique. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against a panel of pathogenic strains. The majority of compounds possessed noticeably inhibitory action against E. Coli, S. Typhi, P. Aeruginosa, C. tetani, S. aureus and B. subtillis. Among all compounds, I [R1 = H, R2 = 4-methylpiperidin-1-yl; R1 = Me, R2 = 4-methylpiperazin-1-yl] exhibited excellent inhibitory action against E.Coli and P. Aeruginosa strain, resp., as compared to standard drug. One compound I [R = Me, R1 = OEt] showed remarkable potency against fungal strain. Mol. docking study was carried out to understand binding of compound with protein. In silico ADME prediction was carried out to check physicochem. properties of synthesized compound1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, Ban; Mccabe, Gavin E.; Parrish, Mitchell J.; Singh, Jujhar; Zeller, Matthias; Deng, Yongming published an article in 2022. The article was titled 《Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles》, and you may find the article in Advanced Synthesis & Catalysis.Computed Properties of C2H3N3 The information in the text is summarized as follows:

Disclosed herein was a photoinduced selective hydroamination of ynamides with nitrogen heteroaromatic nucleophiles. By using an organocatalytic photoredox system, a direct method to construct a diverse of (Z)-α-aryl enamides I [R1 = Ph, n-hexyl, 4-MeC6H4, etc.; R2 = Me, t-Bu, Bn; R3 = Ms, Ts, Ns; Ar = pyrazol-1-yl, triazol-1-yl, (5-methyltetrazol-2-yl), etc.] from ynamides and pyrazoles, as well as triazoles, benzotriazoles, indazoles, and tetrazoles, was developed, thus providing a photocatalytically synthetic route to heterocyclic motifs common in medicinal agents. Based on the mechanistic studies, the hydroamination was postulated to operate via a mechanism in which the single-electron oxidation of ynamide and the intermediacy of an alkyne radical cation, was responsible for the observed reactivity. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Computed Properties of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Computed Properties of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Nanobundles of Iron Phosphide Fabricated by Direct Phosphorization of Metal-Organic Frameworks as an Efficient Hydrogen-Evolving Electrocatalyst》 was written by Zhao, Ruo; Gao, Song; Wu, Yingxiao; Liang, Zibin; Zhang, Hao; Xia, Wei; Li, Shuai; Zhao, Yusheng; Zou, Ruqiang. Safety of 1H-1,2,3-Triazole And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Transition-metal-based phosphides (TMPs) have been considered as attractive electrocatalysts for water splitting due to their earth-abundance and remarkable catalytic activity. As a representative type of precursors, metal-organic frameworks (MOFs) provide ideal plateaus for the design of nanostructured TMPs. In this work, the hierarchically structured iron phosphide Nanobundles (FeP-500) were fabricated by one-step phosphorization of an iron-based MOF (MET(Fe)) precursor. The derived FeP-500 nanobundles were constructed by quasi-paralleled one-dimensional nanorods with uneven surface, which provided channels for electrolyte penetration, mass transport, and effective exposure of active sites during the water-splitting process. With the addition of conductive Super P, the obtained FeP-500-S exhibited a good electrocatalytic performance towards the hydrogen evolution reaction in alk. electrolyte (1 mol L-1 KOH). Furthermore, to investigate the effect of secondary metal doping, a series of isoreticular MOF precursors and bimetallic TMPs were fabricated. The results indicated that the catalytic performance is structure dominated. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Bioactive 1,2,3-Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications》 was written by da S. M. Forezi, Luana; Lima, Carolina G. S.; Amaral, Adriane A. P.; Ferreira, Patricia G.; de Souza, Maria Cecilia B. V.; Cunha, Anna C.; de C. da Silva, Fernando; Ferreira, Vitor F.. COA of Formula: C2H3N3This research focused ontriazole structural diversity biol active mol; biological activity; cycloaddition; diazocompounds; heterocycles; synthetic methods. The article conveys some information:

The triazole heterocycle is a privileged scaffold in medicinal chem., since its structure is present in a large number of biol. active mols., including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chem. in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biol. active mols. using classical approaches. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis of 1,2,3-triazole group-containing isomannide-based aromatic new polyurethanes》 was written by Bayrak, Fatih; Ay, Emriye; Oral, Ayhan; Karayildirim, Tamer; Ay, Kadir. Name: 1H-1,2,3-TriazoleThis research focused ontriazole group isomannide aromatic polyurethane surface property. The article conveys some information:

Ten new carbohydrate-based aromatic polyurethanes have been synthesized using isomannide and/or a new 1,2,3-triazole isomannide derivative, IV, as the diol source in the polymerization reactions. As the isocyanate source, 1,4-phenylene diisocyanate or 2,4-toluene diisocyanate was used. To synthesize compound IV, isomannide was tosylated, the tosyl groups were substituted with azide, the triazole ring was formed by reaction with 2,4-pentane dione and finally carbonyl groups were converted into oximes. The synthesis of copolymers and terpolymers was performed using different proportions of diisocyanate and diol sources in DMF. The structural elucidation of the synthesized compounds and polymers was performed using spectroscopic techniques such as FTIR, 1D- and 2D-NMR and HRMS. The thermal behavior and mol. weight distribution of polymers were analyzed by thermal gravimetric anal. and gel permeation chromatog., resp. The surface properties of the polymers were analyzed using SEM. A comparative study on thermal behavior of the synthesized polymers showed that polymers containing a higher amount of compound IV displayed better thermal stability. The average mol. weights of copolymers were observed to vary from 7,900 (PUR-3) to 21,000 (PUR-4) whereas for terpolymers, values of 19,000 (PUR-5), 5,100 (PUR-6), 22,000 (PUR-8) and 28,000 (PUR-9) were found. The diisocyanate source was found to have more effect on the surface properties of polymers than the diol source: when 2,4-toluene diisocyanate was used in polymer synthesis, the resultant polymers had a spongy morphol. with cavities while a polymer matrix containing spheres and platelets was obtained when 1,4-toluene diisocyanate was used. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sandahl, Alexander F.; Nguyen, Thuy J. D.; Hansen, Rikke A.; Johansen, Martin B.; Skrydstrup, Troels; Gothelf, Kurt V. published an article in 2021. The article was titled 《On-demand synthesis of phosphoramidites》, and you may find the article in Nature Communications.Product Details of 288-36-8 The information in the text is summarized as follows:

Automated chem. synthesis of oligonucleotides is of fundamental importance for the production of primers for the polymerase chain reaction (PCR), for oligonucleotide-based drugs, and for numerous other medical and biotechnol. applications. The highly optimized automised chem. oligonucleotide synthesis relies upon phosphoramidites as the phosphate precursors and one of the drawbacks of this technol. is the poor bench stability of phosphoramidites. Here, we report on the development of an on-demand flow synthesis of phosphoramidites from their corresponding alcs., which is accomplished with short reaction times, near-quant. yields and without the need of purification before being submitted directly to automated oligonucleotide synthesis. Sterically hindered as well as redox unstable phosphoramidites are synthesized using this methodol. and the subsequent couplings are near-quant. for all substrates. The vision for this technol. is direct integration into DNA synthesizers thereby omitting manual synthesis and storage of phosphoramidites. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Copper-Catalyzed Oxidative C-H Bond Functionalization of N-Allylbenzamide for Regioselective C-N and C-O Bond Formation》 was written by Ranjith, Jala; Krishna, Palakodety Radha. Synthetic Route of C2H3N3This research focused ontriazole allylbenzamide copper catalyst oxidative carbon nitrogen bond formation; amino imide preparation; allylbenzamide copper catalyst hydrogen carbon oxygen bond functionalization regioselective; imide preparation; copper; imides; oxidative coupling; oxo-amination; regioselectivity. The article conveys some information:

Copper-catalyzed oxidative couplings of N-allylbenzamides for C-N and C-O bond formations have been developed through C-H bond functionalization. To demonstrate the utility of this approach, it was applied to the synthesis of β-aminoimides and imides. To the best of our knowledge, these are the first examples in which different classes of N-containing compounds have been directly prepared from the readily available N-allylbenzamides using an inexpensive catalyst/oxidant/base (CuSO4/TBHP/Cs2CO3) system. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,3-TriazoleIn 2021 ,《Azole as privileged heterocycle for targeting the inducible cyclooxygenase enzyme》 appeared in Drug Development Research. The author of the article were Prasher, Parteek; Sharma, Mousmee. The article conveys some information:

A review. An over-expression of COX-2 isoenzyme belonging to the Cyclooxygenase Enzyme Family triggers the overproduction of pro-inflammatory prostaglandins that instigate the development of chronic inflammation and related disorders. Hence, the rationally designed drugs for mitigating over-activity of COX-2 isoenzyme play a regulatory role toward the alleviation of the progression of these disorders. However, a selective COX-2 inhibition chemotherapy prompts several side effects that necessitate the identification of novel mol. scaffolds for deliberating state-of-the-art drug designing strategies. The heterocyclic “”azole”” scaffold, being polar and hydrophilic, possesses remarkable physicochem. advantages for designing physiol. active mols. capable of interacting with a wide range of biol. components, including enzymes, peptides, and metabolites. The substituted derivatives of azole nuclei enable a comprehensive SAR anal. for the appraisal of bioactive profile of the deliberated mols. for obtaining the rationally designed compounds with prominent activities. The comprehensive SAR anal. readily prompted the identification of Y-shaped mols. and the eminence of bulkier group for COX-2 selective inhibition. This review presents an epigrammatic collation of the pharmacophore-profile of the chemotherapeutics based on azole motif for a selective targeting of the COX-2 isoenzyme. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics