Category: 16681-70-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 16681-70-2

H. (2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid isopropyl ester (R4=H; R7=-CH(CH3)2) (2S,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid (76 mg, 242 mumol) in MeCN (0.4 mL, 8 mmol) and 4 M HCl in 1,4-dioxane (242 muL, 969 mumol) was combined with propan-2-ol (0.5 mL) at 60 C. The resulting mixture was stirred until solid precipitation was observed (~30 minutes). The solvent was evaporated under vacuum and the solids were azeotroped in toluene and dried under vacuum. 1,2,3-Triazole-4-carboxylic acid (0.0274 g, 0.242 mmol), DIPEA (169 muL, 969 mumol) and HATU (92 mg, 242 mumol) were combined in DMF (0.2 mL) and stirred for 5 minutes at room temperature. This was then combined with the dried solids, predissolved in DMF (0.2 mL) and DIPEA (0.5 eq.). The resulting mixture was stirred for 15 minutes and the reaction was quenched with AcOH. The product was purified by preparative HPLC and lyophilized to yield the title compound (38 mg; purity 95%). MS m/z [M+H]+ calc’d for C25H30N4O4, 451.23. found 451.4.

According to the analysis of related databases, 16681-70-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THERAVANCE, INC.; US2012/213806; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1H-[1,2,3]Triazole-4-carboxylic acid

1,2,3-Triazole-4-carboxylic acid (14 mg, 124 mumol), DIPEA (86.3 muL, 496 mumol) and HATU (47.1 mg, 124 mumol) were combined in DMF (0.2 mL) and stirred for 5 minutes at room temperature. This was then combined with (2S,4R)-4-amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid ethoxycarbonyloxymethyl ester (51 mg, 120 mumol). The resulting mixture was stirred for 15 minutes and the reaction was quenched with AcOH. The product purified by preparative HPLC and lyophilized to yield the title compound (5 mg; purity 90%). MS m/z [M+H]+ calc’d for C26H30N4O2, 511.21. found 511.6.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16681-70-2.

Reference:
Patent; THERAVANCE, INC.; US2012/213806; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 1H-[1,2,3]Triazole-4-carboxylic acid

[0618] 3H-1,2,3-triazole-5-carboxylic acid (1.1 mg, 10.0f.tmol) was combined with HATU (3.0 mg, 7.8 flillOI) in DMF(0.5 mL) and stirred for 10 minutes; DIPEA (1.0 eq.) wasadded and the mixture was stirred for 1 minute. Compound 2(4.9 mg, 11 f.tmol) was dissolved in DMF (1 mL) and DIPEA(5.8 f.LL, 33 mmol) was added, followed by addition of theactivate acid solution. The mixture was stirred for 30 minutesto yield Compound 3.

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 16681-70-2, The chemical industry reduces the impact on the environment during synthesis 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

[0864] lH-1,2,3-triazole-4-carboxylic acid (9.8 mg, 87f.tmol) and HATU (36.4 mg, 96 f.tmol) were combined in DMF(3.0 mL) and stirred at room temperature for 15 minutes. Compound 2 (40.3 mg, 87 fllllOl) and DIPEA (46 f.LL, 261f.tmol) were added and the resulting solution was stirred atroom temperature for 15 minutes, after which time LCMSindicated desired product formation. The solvent wasremoved in vacuo and the crude residue was purified byreverse phase chromatography to yield Compound c (34.5mg) as a TFA salt. MS m/z [M+Ht calc’d forC28H33ClFN50 4 , 558.22. found 558.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, COA of Formula: C3H3N3O2

cyanopyrrolidin-1 -yl)-2-oxoethyl)-1 H-1 ,2,3-triazole-5-carboxamide 1 H-1 ,2,3-triazole-4-carboxylic acid (0,092 g, 0,814 mmol) was dispersed in dry dioxane (3m L) in a round bottom flask with nitrogen. To this 1 -chloro-N,N,2-trimethylprop-1 -en-1 -amine (0,151 ml, 1 ,139 mmol) was added and the reaction was stirred for 30 minutes at room temperature. The starting material dissolves over time, Then (S)-1 -(2-aminoacetyl)pyrrolidine-2-carbonitrile hydrochloride (0,247 g, 1 ,302 mmol) with N-ethyl-N-isopropylpropan-2-amine (0,307 ml, 1 ,709 mmol) was added and the mixture was stirred for 2h, evaporated to dryness and redissolved in ethyl acetate. Followed by washing with 0.1 N citric acid and saturated sodium bicarbonate and – – brine. After drying over sodium sulfate, filtration and evaporation, the product was purified using column chromatography. Yield: 34mg, 40% 1 H NMR (400 MHz, DMSO) (9/1 mixture of trans/cis amide rotamers) delta 15.53 (s, 1 H), 8.58 – 8.44 (s, 1 H), 8.39 (s, 1 H), 5.28 – 5.22 (m, 0.1 H), 4.77 (dd, J = 3.76, 7.32 Hz, 1 H), 4.30 (dd, J = 5.61 , 16.77 Hz, 0.2H), 4.10 (d, J = 5.76 Hz, 2H), 3.68 (ddd, J = 4.04, 7.68, 9.39 Hz, 1 H), 3.50 (td, J = 6.84, 9.09 Hz, 1 H), 2.31 – 1 .88 (m, 4H). UPLC I (ESI) Rt 0.72 min, m/z 249.6 [M+H]+ (96%) ; LC-MS (l-B) Rt 4.0 min, m/z 249.0 [M+H]+ (96%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITEIT ANTWERPEN; FOX CHASE CANCER CENTER; JANSEN, Koen; DE MEESTER, Ingrid; HEIRBAUT, Leen; CHENG, Jonathan D; JOOSSENS, Jurgen; AUGUSTYNS, Koen; VAN DER VEKEN, Pieter; WO2013/107820; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 16681-70-2, The chemical industry reduces the impact on the environment during synthesis 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

lH-l,2,3-triazole-5-carboxylic acid (55.9 mg, 494 muiotaetaomicron) was combined with HATU (188 mg, 494 mupiiotaomicron) in DMF (0.5 mL) and stirred for 10 minutes; DIPEA (1.5 eq.) was added and the mixture was stirred for 1 minute. Compound 3 (200 mg, 494 muiotaetaomicron) was dissolved in DMF (1 mL) and DIPEA (259 mu^, 1.5 mmol) was added, followed by addition of the activated acid solution. The mixture was stirred for 30 minutes and the solvent was evaporated. The mixture was purified by normal phase chromatography (0-100% (0791) EtOAc/hexanes) to yield Compound 4 (100 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1H-[1,2,3]Triazole-4-carboxylic acid

[0674] Compound 10 (32 mg, 75 fllllOl, 1.0 eq.) was dissolvedinDMF(500 f.LL). lH-1,2,3-triazole-4-carboxylic acid(25 mg, 221 f.tmol, 3.0 eq.) was dissolved in DMF (500 f.LL),followed by the additionofDIPEA (51 f.LL, 297 f.tmol, 4.0 eq.)and HATU ( 42 mg, 111 f.tmol, 1.5 eq.). The solutions werestirred at room temperature for 20 minutes, then combinedand stirred at room temperature for an additional 20 minutesand when the reaction was complete (as determined byLC/MS analysis), the mixture was diluted with water (0.5mL), the pH adjusted to 4 with 10% citric acid, then washedwith EtOAc (2×20 mL). The aqueous phase was discardedand the combined organics were extracted with saturatedaqueous NaCl (10 mL). The aqueous phase was discarded andthe organic phase was dried over Na2S04 , filtered, and concentratedin vacuo, and purified by preparative HPLC to yieldthe title compound (11 mg; purity 99.6% ). LCMS (ESI): calc.C27H31N50 4=489; obs. M+H=490.2. Retention time: 4.23mm.

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, Safety of 1H-[1,2,3]Triazole-4-carboxylic acid

To a stirred solution of 9-3 (2.Og, 3.6mMol), HOBT (0.5g, 3.9mMol), and 1H-1,2,3- triazole-4-carboxylic acid (0.4g, 3.9mMol) in anhydrous DMF (2OmL) was added DIEA (1.2mL, 7.2mMol) followed by EDC (0.76g, 3.9mMol). The solution was stirred at ambient temperature overnight. The solution was then treated with 2mL of acetic acid and was heated to 800C for 3hrs. Upon cooling to room temperature, the solution was filtered through a syringe filter and purified on a C18 reverse phase HPLC to give 9-4 as a solid. Mass (M+l) calculated: 631.2789 observed: 631.2778

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 16681-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

3H-l,2,3-triazole-5-carboxylic acid (2.5 mg, 22 muiotaetaomicron) was combined with HATU (8.4 mg, 22 muiotaetaomicron) in DMF (0.3 mL) and stirred for 10 minutes; Et3N (1 eq.) was added and the mixture was stirred for 1 minute. Compound 2 (22 muiotaetaomicron) was dissolved in DMF (0.5 mL) and Et3N (3.1 mu, 22 muiotaetaomicron) was added, followed by addition of the activated acid solution. The mixture was stirred for 30 minutes, concentrated, and purified by preparative HPLC to yield the title compound. MS m/z [M+H]+ calc’d for C27H31CIFN5O4, 544.21 ; found 544.2.

The chemical industry reduces the impact on the environment during synthesis 1H-[1,2,3]Triazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 16681-70-2,Some common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0780] 3H-1,2,3-triazole-5-carboxylic acid (2.5 mg, 22f.tmol) was combined with HATU (8.4 mg, 22 f.tmol) in DMF(0.3 mL) and stirred for 10 minutes; Et3N (1 eq.) was addedand the mixture was stirred for 1 minute. Compound 2 (22f.tmol) was dissolved in DMF (0.5 mL) and Et3N (3.1 f.LL, 22f.tmol) was added, followed by addition of the activated acidsolution. The mixture was stirred for 30 minutes, concentrated,and purified by preparative HPLC to yield the titlecompound. MS m/z [M + Ht calc’ d for C24H27CIFN 50 3 , 488.18; found 488.2.

The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics