16681-70-2 -| Page 19 of 30

Simple exploration of 16681-70-2

The synthetic route of 1H-[1,2,3]Triazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 16681-70-2

[0870] lH-1,2,3-triazole-4-carboxylic acid (9.8 mg, 87f.tmol) and HATU (36.4 mg, 96 f.tmol) were combined in DMF(3.0 mL) and stirred at room temperature for 15 minutes.Compound 1 (49.3 mg, 106 f.tmol) and DIPEA (46 f.LL, 261f.tmol) were added and the resulting solution was stirred atroom temperature for 15 minutes, after which time LCMSindicated desired product formation. The solvent wasremoved in vacuo and the crude residue was purified byreverse phase chromatography.

The synthetic route of 1H-[1,2,3]Triazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The important role of 16681-70-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, Computed Properties of C3H3N3O2

HATU (79 mg, 207 mumol) was added to a stirred solution of 1H-1,2,3-triazole-4-carboxylic acid (23 mg, 207 mumol) in DMF (1.3 mL) and stirred for 10 minutes. DIPEA (49 mg, 376 mumol) was added and after 5 minutes, Compound 2 (66 mg, 188 mumol) pre-dissolved in DMF and DIPEA (1.3 mL, 2 eq.) was added. After 90 minutes LCMS indicated the major product. The mixture was then concentrated in vacuo. The product was determined to be a mixture of the isomers with an additional impurity. The product was purified by preparative HPLC to yield the title isomer a (2.75 min retention time; 1.1 mg) and b (2.68 min retention time; 3.1 mg) as TFA salts.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/209352; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 16681-70-2

The chemical industry reduces the impact on the environment during synthesis 1H-[1,2,3]Triazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

Electric Literature of 16681-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 11-3 (0.2g, 0.36mMol), HOBT (0.05g, 0.4mMol), and IH-1, 2,3- triazole-4-carboxylic acid (0.05g, 0.4mMol) in anhydrous DMF (2mL) was added DIEA (0.18mL, 1. ImMoI) followed by EDC (0.08g, 0.4mMol). The solution was heated in the microwave reactor for 30 minutes at 800C. Solution was then treated with 0.5mL of acetic acid and was heated to 800C in the microwave reactor for lOmin. Upon cooling to room temperature, the solution was passed through a EPO syringe filter and purified on a C18 reverse phase HPLC to give 11-4 as a solid. Mass (M+l) calculated: 632.2742 observed: 632.274

The chemical industry reduces the impact on the environment during synthesis 1H-[1,2,3]Triazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The important role of 16681-70-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-[1,2,3]Triazole-4-carboxylic acid, its application will become more common.

Synthetic Route of 16681-70-2,Some common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 3 (30 mg, 199 muiotaetaomicron) was combined with 3H-[l,2,3]triazole-4- carboxylic acid (22 mg, 199 muiotaetaomicron), HATU (76 mg, 199 muiotaetaomicron) and DIPEA (104 mu, 596 muiotaetaomicron) in DMF (1 mL) and stirred at room temperature for 20 minutes then concentrated in vacuo and the crude residue was purified by normal phase chromatography (0-100% EtOAc/hexanes). The intermediate (30 mg, 67 muiotaetaomicron) was dissolved in THF (1 mL) and 10N NaOH (268 mu^, 268 muiotaetaomicron) and stirred at room temperature for 1 hour. The mixture was acidified with AcOH and purified by preparative HPLC to yield Compound 4 (10 mg).

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Simple exploration of 16681-70-2

Related Products of 16681-70-2,Some common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0625] (2S,4S)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-cyanomethylpentanoic acid ethyl ester (55 mg, 141f.tmol) was combined with 3H-[1,2,3]triazole-4-carboxylicacid (19.2 mg, 170 f.tmol), HATU (64.5 mg, 170 flillOI) andDIPEA (79 f.LL, 453 f.tmol) in DMF (2 mL) and was stirred atroom temperature for 30 minutes then concentrated in vacuo and the crude residue was purified by normal phase chromatography(0-100% EtOAc/hexanes) to yield Compound 1.55mg).

Introduction of a new synthetic route about 16681-70-2

0867] lH-1,2,3-triazole-5-carboxylic acid (15.3 mg, 135f.tmol) andHATU (51.4mg, 135 fJ.mol)weremixedinDMF (4mL) and stirred at room temperature for 15 minutes. (2S,4S)-4-Amino-2-(1-amino-l-methylethyl)-5-( 5′-chloro-2′-fluorobiphenyl-4-yl)pentanoic acid ethyl ester (50 mg, 123 f.tmol)and DIPEA (64 f.LL, 369 f.tmol) were added. The resultingsolution was stirred at room temperature for 15 minutes, atwhich point LC/MS showed reaction completion. The solventwas removed in vacuo and the crude residue was diluted inEtOH (4 mL). A solution of IN LiOH (983 f.LL, 983 f.tmol) inwater was then added. The resulting solution was stirred at60 C. for 2 days, at which point LC/MS showed reactioncompletion. The solvent was removed in vacuo and the cruderesidue was purified by preparative HPLC to yield the titlecompound (4.2mg) as a TFA salt. MS rn/z [M+Ht calc’dforC23H25ClFN50 3 , 474.16. found 474.2.

New learning discoveries about 16681-70-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 16681-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.

1H-1,2,3-triazole-4-carboxylic acid (3.3 mg, 29 imol) and HATU (10.5 mg, 28 .imol) were dissolved in DMF (2.0 mL) and stirred for 15 minutes at room temperature. 2- [(R)-2-Amino-3 -(5?-chloro-2?-fluorobiphenyl-4-yl)propyl] -2-methylmalonic acid (12.0 mg, 32 .imol) and DIPEA (9.2 .iL, 53 .imol) were added, and the resulting mixture was stirred for 15 minutes at room temperature, at which time LCMS indicated the mass of the desiredcompound. The mixture was concentrated in vacuo and the residue was purified by preparative HPLC to yield the title compound (5 mg) as a TFA salt. MS m/z [M+H] calc?d for C22H20C1FN405, 475.11; found 475.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116760; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The important role of 16681-70-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 16681-70-2

[0708] 18-1,2,3-triazole-5-carboxylic acid (1.1 mg, 10.0f.tmol) was combined with HATU (3.0 mg, 7.8 flillOl) in DMF(0.5 mL) and stirred for 10minutes; DIPEA (1 eq.)was addedand the mixture was stirred for 1 minute. Compound 2 (5.0mg, 11 f.tmol) was dissolved in DMF (1 mL) and DIPEA (5.8f.LL, 33 flillOl) was added, followed by addition of the activatedacid solution. The mixture was stirred for 30 minutes to yieldCompound3.

Continuously updated synthesis method about 16681-70-2

The synthetic route of 1H-[1,2,3]Triazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

[0784] 1H-1,2,3-triazole-5-carboxylic acid (3.4 mg, 30f.tmol) was combined with HATU (11 mg, 30 f.tmol) in DMF(0.3 mL) stirred at room temperature for 10 minutes; DIPEA(1 eq.) was added and the mixture was stirred for 1 minute.Compound 2 (10 mg, 30 f.tmol) was dissolved in DMF (0.5mL) and DIPEA (5.2 f.LL, 30 f.tmol) was added, followed byaddition of the activated acid solution. The mixture wasstirred at room temperature for 30 minutes, after which timeLCMS indicated desired product formation. Half of the crudeproduct was purified using reverse phase chromatography toyield Compound a as a TFA salt (1 mg). MS m/z [M+Htcalc’d for C26H31CIFN50 4 , 532.21. found 532. Half of thecrude product was carried to the next step without furtherpurification.

The synthetic route of 1H-[1,2,3]Triazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Continuously updated synthesis method about 16681-70-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-[1,2,3]Triazole-4-carboxylic acid, and friends who are interested can also refer to it.

[0769] 3H-1,2,3-triazole-5-carboxylic acid (2.5 mg, 22f.tmol) was combined with HATU (8.4 mg, 22 flillOI) in DMF(0.3 mL) and stirred for 10 minutes; Et3N (1 eq.) was addedand the mixture was stirred for 1 minute. Compound 2 (22f.tmol) was dissolved in DMF (0.5 mL) and Et3N (3.1 f.LL, 22f.tmol) was added, followed by addition of the activated acidsolution. The mixture was stirred for 30 minutes, concentrated,and purified by preparative HPLC to yield Compounda (8 mg) as a TFA salt. MS m/z [M+Ht calc’d forC26H29CIFN50 3 , 514.19. found 514.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-[1,2,3]Triazole-4-carboxylic acid, and friends who are interested can also refer to it.