Category: 105020-39-1

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 105020-39-1, name is Methyl 2-Methyl-1,2,3-triazole-4-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Formula: C5H7N3O2

Step 2:; 2-methyl 2H-1 ,2,3-triazole-4-carboxylic acid methyl ester (263 mg, 1.86 mmol) is charged in a round-bottom flask, then THF (15 mL), 1 M solution NaOH (9.3 mL, 9.3 mmol, 5.0 equiv) and MeOH (5 mL) are measured and mixed in a graduated cylinder, then added to the flask. The solution is stirred at RT. After 4 h, 1 M HCI is added (10 mL) and the solvent is evaporated. EtOAc is added and the layers are separated. The solvent is evaporated which affords the product R2j.1H NMR (400 MHz,DMSO-d6): delta 8.17 (s, 1 H), 4.22 (s, 3H).

If you are hungry for even more, make sure to check my other article about 105020-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET, Montse; BORDELEAU , Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, Benoit; O’MEARA, Jeffrey; WO2011/63501; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105020-39-1, name is Methyl 2-Methyl-1,2,3-triazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate

Step2:; 2-methyl 2H-1 ,2,3-triazole-4-carboxylic acid methyl ester (263 mg, 1 .86 mmol) is charged in a round-bottom flask, then THF (15 mL), 1 M solution NaOH (9.3 mL, 9.3 mmol, 5.0 equiv) and MeOH (5 mL) are measured and mixed in a graduated cylinder, then added to flask. Solution is stirred at room temperature. After 4 h, 1 M HCI is added (10 mL) and solvent is evaporated. EtOAc is added and layers are separated. Solvent is evaporated. Desired product R2I is obtained as a white solid (215 mg, 91 %).1H NMR (400 MHz,DMSO-d6): delta 8.17 (s, 1 H), 4.22 (s, 3H).

According to the analysis of related databases, 105020-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET , Montse; BORDELEAU, Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, Benoit; O’MEARA, Jeffrey; WO2011/63502; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

105020-39-1, name is Methyl 2-Methyl-1,2,3-triazole-4-carboxylate, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H7N3O2

Step 2:; 2-methyl 2H-1 ,2,3-triazole-4-carboxylic acid methyl ester (263 mg, 1.86 mmol) is charged in a round-bottom flask, then THF (15 mL), 1 M solution NaOH (9.3 mL, 9.3 mmol, 5.0 equiv) and MeOH (5 mL) are measured and mixed in a graduated cylinder, then added to the flask. The solution is stirred at RT. After 4 h, 1 M HCI is added (10 mL) and the solvent is evaporated. EtOAc is added and the layers are separated. The solvent is evaporated which affords the product R2j.1H NMR (400 MHz,DMSO-d6): delta 8.17 (s, 1 H), 4.22 (s, 3H).

The synthetic route of 105020-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET, Montse; BORDELEAU , Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, Benoit; O’MEARA, Jeffrey; WO2011/63501; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics