Recently I am researching about CYTOTOXIC ACTIVITY; DERIVATIVES, Saw an article supported by the Natural Science Foundation of Shaanxi Province of ChinaNatural Science Foundation of Shaanxi Province [2018JQ2033]; Key Research and Development Project of Shaanxi Province of China [2018ZDXM-NY-064]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21402156]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Fan, NJ; Tang, JJ; Li, YF; Bai, YB; Zhao, XM. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. COA of Formula: C2H4N4
A facile strategy for the synthesis of steroidal [1,2,4]triazolo[1,5-a]pyrimidines 5a-g and 6a-g has been accomplished via a one-pot reaction of steroidal ketones, aromatic aldehydes and 3-amino-1,2,4-triazole in the presence of potassium tert-butoxide in refluxing tert-butanol. All the synthesized heterosteroids were evaluated for in vitro antiproliferative activity against human cancer cells by sulforhodamine B (SRB) assays. The preliminary results showed that compounds 6a and 6e possessed potent antiproliferative activities.
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics