Synthetic Route of 118863-62-0,Some common heterocyclic compound, 118863-62-0, name is 3-(4-Bromophenyl)-1H-[1,2,4]triazole, molecular formula is C8H6BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.5 g of 3 -(4-bromophenyl)- 1H- 1,2, 4-triazole prepared in Step 2 was dissolved in 5.0 mL of N,N-dimethylformamide, and the resulting reaction mixture was cooled to 0C. To the reaction mixture, 0.32 g of sodium hydride was added, and then the reaction mixture was stirred for 30 minutes. 1.67 g of (2-(chloromethoxy)ethyl)trimethylsilane was added thereto and the reaction mixture was then stirred at 0C for 15 minutes and additionally stirred for 2 hours further. Distilled water was added and the reaction mixture was extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give a residue as a yellow liquid. The residue was purified with silica gel column chromatography (developing solvent: n-hexane/ethyl acetate = 2/1) to give 1.1 g of the title compound as a yellow solid (yield: 46.3 %). 1H-NMR (CDCl3, 400 MHz) d 8.25(s, 1H), 8.0l(d, 2H), 7.58(d, 2H), 5.52(s, 2H), 3.69(t, 2H), 0.96(t, 2H), 0.00(s, 9H)
The synthetic route of 118863-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YUHAN CORPORATION; HAN, Tae Dong; TAK, Hee Jae; KIM, Eun Kyung; CHOI, Su Bin; KIM, Dong Hoon; PARK, Sol; JUNG, Eun Hye; CHOI, Hyun Ho; KIM, Tae Wang; JU, Mi Kyeong; HA, Na Ry; (305 pag.)WO2019/180644; (2019); A1;,
1,2,3-Triazole – Wikipedia,
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