These common heterocyclic compound, 584-13-4, name is 4H-1,2,4-Triazol-4-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 584-13-4
In a 500 ml three-necked flask, 8.40 g (0.1 mol) of 4-amino-1,2,4-triazole and 200 ml of acetonitrile solvent were successively added.After the solid matter was completely dissolved, 84.4 g (0.1 mol) of iodomethane was added dropwise to the solution in portions while stirring.After the addition was complete, the solution was slowly warmed to 40 C and reacted for 8 h.After purification treatment, an intermediate 1-methyl-4-amino-1,2,4-triazole iodide salt is obtained, which is then reacted with a solution containing 17 g (0.1 mol) of silver nitrate in methanol (200 ml) and distilled under reduced pressure to obtain Liquid state1-methyl-4-amino-1,2,4-triazole nitrate 14.6 g,The yield is 90.7%.
The synthetic route of 4H-1,2,4-Triazol-4-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hubei Space Flight Chemical Technology Institute; Du Fang; Li Lei; Fu Xiaomeng; Hu Jianjiang; Wang Rui; Wang Ning; He Tieshan; (5 pag.)CN107868061; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics