Some common heterocyclic compound, 162848-16-0, name is 4-[1,2,4]Triazol-1-yl-benzoic acid, molecular formula is C9H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 162848-16-0
General procedure: To a solution of benzoic acid derivative (0.50 mmol, 1 equiv.) in CH2Cl2 (7.5 mL) cooled in an ice-bath, Et3N (1.50 mmol, 3 equiv.) and TBTU (0.65 mmol, 1.3 equiv.) were added. After 10 min, the corresponding amine (0.50 mmol, 1 equiv.) was added, and the reaction mixture was left to react for 1 h at room temperature. The reaction mixture was diluted with CH2Cl2 (30 mL) and the organic phase was washed with 1 M aqueous HCl (3 15 mL), saturated aqueous solution of NaHCO3 (3 15 mL), and brine (30 mL), and dried over Na2SO4. The solvent was evaporated under reduced pressure.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 162848-16-0, its application will become more common.
Reference:
Article; Pajk, Stane; ?ivec, Matej; ?ink, Roman; Sosi?, Izidor; Neu, Margarete; Chung, Chun-Wa; Martinez-Hoyos, Maria; Perez-Herran, Esther; Alvarez-Gomez, Daniel; Alvarez-Ruiz, Emilio; Mendoza-Losana, Alfonso; Castro-Pichel, Julia; Barros, David; Ballell-Pages, Lluis; Young, Robert J.; Convery, Maire A.; Encinas, Lourdes; Gobec, Stanislav; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 252 – 257;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics