In 2015,Berchel, Mathieu; Haddad, Jimmy; Le Corre, Stephanie S.; Haelters, Jean-Pierre; Jaffres, Paul-Alain published 《Synthesis of lipid-based unsymmetrical O,O-dialkylphosphites》.Tetrahedron Letters published the findings.Formula: C12H22F6N6OP2 The information in the text is summarized as follows:
An efficient method for the synthesis of unsym. lipid-based O,O-dialkylphosphites is reported. The reaction implies the use of H-phosphonates monoester ammonium salt which is coupled with a fatty alc. in the presence of an optimized quantity of pivaloyl chloride (Piv-Cl) as coupling reagent. The reaction conditions offer access to a wide panel of unsym. O,O-dialkylphosphites including either non-functionalized lipid derivatives (lauryl, dodecyl tetradecyl, hexadecyl, octadecyl), lipid (phytanyl), unsaturated lipids (oleyl, linoleyl) or ω-functionalized alkyl alcs. (azide, propargyl, alkenyl). The experimental part of the paper was very detailed, including the reaction process of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Formula: C12H22F6N6OP2)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Formula: C12H22F6N6OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics