Application of 288-88-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 288-88-0, Name is 1H-1,2,4-Triazole, SMILES is N1N=CN=C1, belongs to Triazoles compound. In a article, author is Lawal, Nasir S., introduce new discover of the category.
Cu(I) mediated hydrogen borrowing strategy for the alpha-alkylation of aryl ketones with aryl alcohols
New triazolium Schiff bases (TSBs) were synthesised via a simple and high throughput process. The new salts were successfully characterised. When reacted with Cu(CH3CN)(4)PF6, the TSB salts formed mononuclear triazole Schiff base copper(I) complexes and dinuclear complexes that were also characterised. The copper complexes were generated in situ (mixtures of TSB salts with Cu(CH3CN)(4)PF6) and applied as homogeneous catalysts for the C-C coupling of a variety of aryl ketones with aryl alcohols, from which significant reactivity was observed. Reaction conditions were optimised, and the results indicate that the catalyst systems are very robust. A catalyst concentration of 10 mol% efficiently and selectively catalysed the alpha-alkylation of methyl phenyl ketone and its derivatives to afford up to 94% yield of 1,3-diphenylpropan-1-one and its analogues. The process is adaptable with analogues of acetophenone and benzyl alcohol bearing various regulating substituents tolerated. Graphic abstract
Application of 288-88-0, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 288-88-0 is helpful to your research.