Application of 103755-58-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 103755-58-4 name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of primary alcohol intermediate 43 (1.7 g, 9.71 mmol) in anhydrous DCM (20 mL) was added PBr3 (7.89 g, 29.13 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. The reaction mixture was quenched by adding H2O (20 mL) slowly, adjusted the pH to 7-8 with NaHCO3. The organic phase was separated and aqueous layer was extracted with DCM (20 mL ¡Á 2). The combined organic layers were dried over Na2SO4. The solvent was removed in vacuo and the residue was purified by silica gel column (PE/EtOAc = 4:1) to afford bromine intermediate 44 (1.11 g, 48%) as a white solid. Mp: 126-130 C, TLC Rf = 0.70 (PE/EtOAc = 2:1); 1H NMR (600 MHz, CDCl3, delta ppm): 8.02 (s, 1H), 7.74-7.72 (m, 2H), 7.56-7.53 (m, 2H), 7.48-7.45 (m, 1H), 4.66 (s, 2H); MS (ESI) m/z calcd for C9H8BrN3 [M +2 + H]+: 240.0, found: 240.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Qin, Yinhui; Teng, Yuetai; Ma, Ruixin; Bi, Fangchao; Liu, Zhiyang; Zhang, Panpan; Ma, Shutao; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 321 – 339;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics