Reference of 16681-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
3H-l,2,3-triazole-5-carboxylic acid (2.5 mg, 22 muiotaetaomicron) was combined with HATU (8.4 mg, 22 muiotaetaomicron) in DMF (0.3 mL) and stirred for 10 minutes; Et3N (1 eq.) was added and the mixture was stirred for 1 minute. Compound 2 (22 muiotaetaomicron) was dissolved in DMF (0.5 mL) and Et3N (3.1 mu, 22 muiotaetaomicron) was added, followed by addition of the activated acid solution. The mixture was stirred for 30 minutes, concentrated, and purified by preparative HPLC to yield the title compound. MS m/z [M+H]+ calc’d for C27H31CIFN5O4, 544.21 ; found 544.2.
The chemical industry reduces the impact on the environment during synthesis 1H-[1,2,3]Triazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics