Synthetic Route of 143426-50-0,Some common heterocyclic compound, 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, molecular formula is C9H9N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of (4-(1 H-1 ,2,4-triazol-1-yl)phenyl)methanol (133 mg, 0.76 mmol) in dry DCM (2 mL), SOCI2 (0.1 mL, 1.52 mol) was added at 0 C and the resulting mixture was stirred for 3 h at RT. The completion of the reaction was monitored by TLC. The reaction mixture was concentrated under vacuum and the resulting product was co-distilled with DCM (2 x 10 mL) to get the title compound that was used without any further purification. Yield: 60% (1 10 mg, pale yellow solid). 1H NMR (400 MHz, DMSO -cfe): d 9.33 (s, 1 H), 8.26 (s, 1 H), 7.89 (d, 8.8 Hz, 2H), 7.64 (d, J = 8.8 Hz, 2H), 4.85 (s, 2H). LCMS: (Method A) 194.1 (M+H), Rt.1.73 min, 79.10% (Max).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, its application will become more common.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics