In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6523-49-5 as follows. Formula: C8H8N4
The product from step 1 (645 mg) was heated in DMF-DMA (4 ml) for 2 h. On cooling the mixture was concentrated and triturated with ether / petrol to give the formamidine as a solid (664 mg). A portion of this material (56 mg) was treated with 4- triazoryl-aniline (35 mg) in AcOH (1.5 ml) at 100 for 2 h, cooled and diluted with water (25 ml). Basified with NaOH, filtered and the solid dried to give the title compound (66 mg).1H NMR delta 10.04 (IH, s), 9.24 (IH, s), 9.13 (2H, s), 8.86 (IH5 s), 8.63 (IH, s), 8.25 (2H, m), 8.04 (2H, m), 7.89 (3H, m), 3.99 (3H, s); LC-MS rt 2.32 m/z 395 ES-.
According to the analysis of related databases, 6523-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
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