In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1H-[1,2,3]Triazole-4-carboxylic acid
[0674] Compound 10 (32 mg, 75 fllllOl, 1.0 eq.) was dissolvedinDMF(500 f.LL). lH-1,2,3-triazole-4-carboxylic acid(25 mg, 221 f.tmol, 3.0 eq.) was dissolved in DMF (500 f.LL),followed by the additionofDIPEA (51 f.LL, 297 f.tmol, 4.0 eq.)and HATU ( 42 mg, 111 f.tmol, 1.5 eq.). The solutions werestirred at room temperature for 20 minutes, then combinedand stirred at room temperature for an additional 20 minutesand when the reaction was complete (as determined byLC/MS analysis), the mixture was diluted with water (0.5mL), the pH adjusted to 4 with 10% citric acid, then washedwith EtOAc (2×20 mL). The aqueous phase was discardedand the combined organics were extracted with saturatedaqueous NaCl (10 mL). The aqueous phase was discarded andthe organic phase was dried over Na2S04 , filtered, and concentratedin vacuo, and purified by preparative HPLC to yieldthe title compound (11 mg; purity 99.6% ). LCMS (ESI): calc.C27H31N50 4=489; obs. M+H=490.2. Retention time: 4.23mm.
The synthetic route of 16681-70-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics