An article Anti-hypertensive effect of hydrogen peroxide acting centrally WOS:000535871700001 published article about RENIN-ANGIOTENSIN SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANTEROVENTRAL 3RD-VENTRICLE AV3V; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; RENAL-HYPERTENSION; PRESSOR-RESPONSES; BLOOD-PRESSURE; RENOVASCULAR HYPERTENSION; CARDIOVASCULAR-RESPONSES in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ, Dent Sch, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil; [Blanch, Graziela T.] Pontifical Catholic Univ Goias, Sch Med Pharm & Biomed, Goiania, Go, Brazil in 2020.0, Cited 69.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 mu mol/1 mu l) or ATZ (5 nmol/1 mu l) icv reduced the pressor responses to ANG II (50 ng/1 mu l) icv in SHRs (11 +/- 3 and 17 +/- 4 mmHg, respectively, vs. 35 +/- 6 mmHg) and 2K1C hypertensive rats (3 +/- 1 and 16 +/- 3 mmHg, respectively, vs. 26 +/- 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.
Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Lauar, MR; Blanch, GT; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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