On August 26, 2021, Wiles, Jason Allan; Gadhachanda, Venkat Rao published a patent.Application In Synthesis of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate The title of the patent was Preparation of pyrimidine-containing compounds for the treatment of Complement factor D – mediated disorders. And the patent contained the following:
The invention relates to preparation of pyrimidine-containing compounds of formulas (I) and (II) or pharmaceutically acceptable salts thereof, as inhibitors of complement factor D. Compounds I and II wherein R1 is halo or C1-2 haloalkyl; R2 is H, halo, C1-3 haloalkyl, etc.; R3 is halo, C1-3 alkyl, or C1-3 haloalkyl; R4 and R5 each independently is H, halo, CN, etc., are claimed. Compds I and II are targeting complement factor D, and inhibit or regulate the complement cascade. The example compound III was prepared via 3-step synthesis using (1R,2S,5S)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid as starting material (procedure given). Compounds I and II are inhibitors of factor D, and reducers of the excessive activation of complement (data given). Compounds I and II can be useful in treatment of Complement factor D – mediated disorders. The experimental process involved the reaction of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate(cas: 1159811-32-1).Application In Synthesis of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
The Article related to pyrimidine preparation complement d disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics