In 2016,Hu, Bei-Bei; Yuan, Yue; Zhou, Xiao-Ping; Li, San-Ming published 《Synthesis and properties of a novel bolaamphiphile surfactant derived from proline》.Chinese Chemical Letters published the findings.COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:
A novel bolaamphiphile surfactant N,N’-(octane-1,8-diyl)bis(pyrrolidine-2-carboxamide) (DAOP), was designed and synthesized from proline and 1,8-diaminooctane, as the hydrophilic part and hydrophobic part, resp. After separation and purification, the structures of the synthesized bola surfactants were verified by IR, MS and 1H NMR. The pKa was measured by a titration experiment, the turbidity was determined using a Shimadzu UV-1750 spectrophotometer, and the critical micelle concentration (CMC) values of the synthesized surfactants in water were obtained using the conductivity and fluorescence probe measurements. The synthesized bolaamphiphile surfactants demonstrate the ability of self-assemble to form vesicles that were confirmed with dynamic light scattering and transmission electron microscopy. The results showed that the novel bolaamphiphile surfactant derived from proline might potentially be an excellent carrier for drug delivery. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics