The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Methylnicotinic acid(SMILESS: O=C(O)C1=CN=C(C)C=C1,cas:3222-47-7) is researched.Application of 13958-93-5. The article 《Escaping from flatland: Substituted bridged pyrrolidine fragments with inherent three-dimensional character》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:3222-47-7).
The pressure to deliver new medicines to the patient continues to grow along with increases in compound failure rate, thus putting the current R&D model at risk. Anal. has shown that increasing the three-dimensionality of potential drug candidates decreases the risk of failure and improves binding selectivity and frequency. For this reason many workers have taken a new look at the power of photochem. as a means to generate novel sp3 rich scaffolds for use in drug discovery programs. Here we report the design, synthesis, and computational structural anal. of a series of 2,4-methanoprolines having inherent 3D character (PMI and PBF scores) significantly higher than that of the broader AbbVie Rule of 3 (Ro3) collection.
The article 《Escaping from flatland: Substituted bridged pyrrolidine fragments with inherent three-dimensional character》 also mentions many details about this compound(3222-47-7)SDS of cas: 3222-47-7, you can pay attention to it, because details determine success or failure
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics