New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 4314-22-1, name is 2-(1H-1,2,3-Triazol-1-yl)acetic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 4314-22-1
To a stirred mixture of 5 (65 mg, 0.173 mmol), 1 – 1 ,2,3-triazoleacetic acid (6, 22 mg, 0.173 mmol), and Hunig’s base (0.091 mL, 0.522 mmol) in DMF (2 ml) was added HATU (66 mg, 0.174 mmol) and the reaction mixture was stirred for 30 min. The crude mixture was directly purified by prep. HPLC to give 7 (39 mg, 46%). -NMR (400MHz, d6-DMSO): 513.0 (s, IH), 8.34 (bs, IH), 8.16-8.1 1 (m, 2H), 8.00-7.95 (m, 2H), 7.71 (s, IH), 7.55-7.42 (m, 2H), 7.19 (q, IH), 5.51-5.43 (2s, 2H), 4.86-4.83 (m, 2H), 3.81-3.52 (m, 4H), 3.13-3.12 (2s, 3H), 3.04-2.97 (2s, 3H), 2.64-2.63 (2s, 3H). MS (EI) for C24H27N, ,0, found 486 (MH+).
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Reference:
Patent; EXELIXIS, INC.; LEAHY, James, William; WO2012/37204; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics