New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles
To a solution of l-chloro-2-(4-methoxybenzyloxy)-4-nitrobenzene (15 g, 51.1 mmol) in DMSO (45 mL) was added potassium hydroxide (4.3 g, 77 mmol) followed by methyl triazole (6.39 g, 77 mmol) at room temperature. The reaction mixture was heated at 95 C for 18 h. The reaction mixture was poured onto crushed ice (1.5 Kg) and extracted with ethyl acetate (3 x 250 mL). It was then washed with brine (3 x 250 mL) and dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was dissolved in dichloromethane (25 mL) and absorbed onto silica (25 g). The resultant slurry of the compound on silica was subjected to flash chromatography using a Teledyne Isco instrument (120 g RediSep silica column, with 50% ethyl acetate in pet-ether) to get Intermediate J(2) (6 g, 34.5%) as a yellow solid and Intermediate J(3) (4.5 g, 24.9%) as a dark brown solid.Analytical data of J(2): LC-MS (M+H)+ = 341.2. IH NMR (400 MHz, CDC13) delta ppm 8.83 (IH, s), 8.13 (IH, d, J=8.8 Hz), 8.06 (IH, s), 8.09 (IH, d, J= 8.8 Hz), 7.35 (2H, d, J=8.4 Hz), 6.94 (2H, d, J= 6.4 Hz), 5.29 (2H, s), 3.83 (3H, s), 2.47 (3H, s).Analytical data of J(3): LC-MS (M+H)+ = 341.2. IH NMR (400 MHz, CDC13) delta ppm 8.03-7.96 (3H, m), 7.57 (IH, d, J= 8.8 Hz), 7.20 (2H, d, J=8.4 Hz), 6.89 (2H, d, J=8.8 Hz), 5.13 (2H, s), 3.80 (3H, s), 2.32 (3H, s).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 3-Methyl-1H-1,2,4-triazole ,and how the biochemistry of the body works.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; THOMPSON III, Lorin A.; WU, Yong-Jin; ZHANG, Yunhui; WO2012/9309; (2012); A1;,
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