Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid
A solution of 2-(2H-1,2,3-triazol-2-yl)benzoic acid (P. Coleman, J. Schreier, WO2007/126934) (1 g, 4.1 mmol) in SOCl2 (10 mL) was stirred at 80 C for 30 min. The solvent was removed under reduced pressure and toluene (10 mL) was added to give solution A. The product from step 4 (1 g, 4.1 mmol) was dissolved in DCM (10 mL), DIEA (1.58 g, 12 mmol) added, and then solution A added at 0 C. The resulting mixture was stirred at RT for 2 h, then poured into water (10 mL) and extracted with DCM (10 mL x 3). The combined organic layers were washed with brine (10 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by chromatography on silica (petroleum ether : EtOAc = 10 : 1 to = 3 : 1) then purified by prep. TLC (petroleum ether : EtOAc = 1 : 1) to give the title compound (0.2 g). LRMS m/z (Mu+Eta) 416.0, 418.0 found, 416.1, 418.1 required.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, in my other articles.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; BESHORE, Douglas, C.; KUDUK, Scott, D.; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/20930; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics