Reference of 7170-01-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0907] A suspension of 6-bromo-7 -( dimethoxymethyl)-1,2,3,4-tetrahydro-1 ,8-naphthyridine (intermediate 12) (300mg, 1.045 mmol), 3-methyl-lH-1,2,4-triazole (104 mg,1.254 mmol), Cs2C03 (720 mg, 2.210 mmol) and Cui ( 40 mg,0.210 mmol) in DMF (2 ml) was heated to 120 C. forapproximately 6 h. The reaction mixture was diluted withethyl acetate and water, layers were separated and the aqueouslayer was extracted with ethyl acetate (3x). Organic layerswere combined, washed with water and brine, dried usingNa2S04 , filtered, evaporated. The crude product was purifiedby silica gel colunm chromatography eluting with a gradientof MeOH (1-10%) in DCM. Product fractions were combined,evaporated and dried to yield the title compound as anorange resin. (UPLC-MS 3) tR 0.57 min; ESI-MS 290.1[M+H]+. 1HNMR(400MHz, CDCI3 ) o8.21 (s, lH), 7.21 (s,lH), 5.35 (s, lH), 4.95 (s, lH), 3.51-3.41 (m, 2H), 3.36 (s,6H), 2.75 (t, 2H), 2.47 (s, 3H), 1.97-1.86 (m, 2H).
By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 3-Methyl-1H-1,2,4-triazole.
Reference:
Patent; Novartis AG; Buschmann, Nicole; Fairhurst, Robin Alec; Furet, Pascal; Knoepfel, Thomas; Leblanc, Catherine; Liao, Lv; Mah, Robert; Nimsgern, Pierre; Ripoche, Sebastien; Xiong, Jing; Han, Bo; Wang, Can; Zhao, Xianglin; US2015/119385; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics