In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 7411-23-6
a) 3 ,5-Dibromo- 1 -(4-methoxy-benzyl)- 1 H-[ 1 ,2,4]triazole 3,5-dibromo-lH-l,2,4-triazole (1.5 g, 6.61 mmol, Eq: 1.00), potassium iodide (110 mg, 661 muiotaetaomicron, Eq: 0.10), 4-methoxybenzyl chloride (1.14 g, 990 mu, 7.27 mmol, Eq: 1.1) and N,N- diisopropylethylamine (1.71 g, 2.31 ml, 13.2 mmol, Eq: 2.0) was stirred in acetonitrile (23.0 ml) overnight at roomtemperature. The crude material was applied on silica gel and purified by column chromatography using heptane / ethyl acetate gradient as eluent to afford 3,5-dibromo-l- (4-methoxy-benzyl)-lH-[l,2,4]triazole (1.79 g / 78.0%) as a white solid. MS: m/e= 345/6/8/50/51 (M+H+), mp: 75.7C
The synthetic route of 7411-23-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KUHN, Bernd; LERNER, Christian; RUDOLPH, Markus; SCHAFFHAUSER, Herve; WO2013/178572; (2013); A1;,
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