In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,5-Dibromo-1H-1,2,4-triazole
2-(2-bromoethoxy)tetrahydro-2H-pyran (10.0 g, 7.23 ml, 47.8 mmol, Eq: 1.00) and DIPEA (6.18 g, 8.35 ml, 47.8 mmol, Eq: 1.00) were added to a suspension of 3,5-dibromo-lH- l,2,4-triazole (10.9 g, 47.8 mmol, Eq: 1.00) in MeCN (90 ml) and then stirred at 90 C for 20 hr. The reaction mixture was cooled to RT, and concentrated in vacuo. The residue was purified by flash column chromatography over silica gel (eluent: EtOAc/ heptane from 10/90 to 60/40) to yield 3, 5-dibromo-l-(2-tetrahydropyran-2-yloxyethyl)-l, 2, 4-triazole (12.08 g, 33.7 mmol, 70% yield) as a light yellow oil. MS (ES+) m/z 356.0 [(M+H)+],
The synthetic route of 7411-23-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; RATNI, Hasane; CARTER, Jennifer Louise; (54 pag.)WO2020/48904; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics