Synthetic Route of 3641-13-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.
3-Nitro-1,2,4-triazole-5-carboxylic acid (HCANT) was made by amodified literature method for conversion of amino-triazoles to thenitro derivative [12]. After addition of NaNO2 (1.10 g, 15.9 mmol) to7 mL of H2SO4 at -5 C, glacial CH3CO2H (15 mL) and finely ground3-amino-1,2,4-triazole-5-carboxylic acid (2.00 g, 15.6 mmol) wereadded. The mixture was then stirred for 10 min to dissolve most ofthe triazole; H2O (25 mL) was then added at a temperature of aroundzero. The resulting yellow solutionwas then added dropwise to a nitritesolution (200 g NaNO2 in 200mL H2O) at 50 C (a rapid addition generatesa hot foam of diazonium salts, with contents erupting from theflask). The green product solution on heating for 2 h at 50 C becomescolourless, and is then extracted with EtOAc (4 ¡Á 50 mL); evaporationof the extracts gives HCANT (1.41 g, 57%). IR: 3416 (N-H, s), 3257(O-H, m), 1710 (C=O, s), 1574 (NO2, m), 1383 (NO2, m), 1268 (m),720 (m). ESI-MS: 159 (M+). Anal. Calcd. for C3H2N4O4: C, 22.78; H,1.28; N, 35.44. Found: C, 22.5; H, 1.4; N, 35.4.
The synthetic route of 5-Amino-4H-1,2,4-triazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kennedy, David C.; James, Brian R.; Inorganic Chemistry Communications; vol. 78; (2017); p. 32 – 36;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics