Electric Literature of 288-88-0,Some common heterocyclic compound, 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 474-( 1 H-1 ,2,4-triazol-1 -yl)-benzoic acidTo a solution of ethyl 4-fluoro-benzoate (1 .68 g) in N-methyl-pyrrolidinone (10 mL) is added 1 ,2,4-triazole (2.5 g) and K2CO3 (1 .5 g) and the mixture is heated at 190 C in a microwave oven for 30 min. After cooling to room temperature, the mixture is acidified with 2 M aqueous HCI and the precipitate is filtered off, washed with a small amount of water and methanol/dichloromethane and dried by suction to give the acid.
The synthetic route of 288-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; HECKEL, Armin; BLUM, Andreas; BREITFELDER, Steffen; HIMMELSBACH, Frank; LANGKOPF, Elke; NOSSE, Bernd; WELLENZOHN, Bernd; ASHWEEK, Neil, J.; HARRIOTT, Nicole; WO2012/123449; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics