Adding a certain compound to certain chemical reactions, such as: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7170-01-6, name: 3-Methyl-1H-1,2,4-triazole
A mixture of 20 (1.1 g, 3.5 mmol) and 3-methyl-1H-1,2,4-triazole (1.4 g, 17.5 mmol) was stirredat 170 C for 2 h. After cooled down to room temperature, the reaction mixture was diluted with H2O(30 mL) and extracted with DCM (30 mL ¡Á 2). The combined organic phases were washed with brine(30 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Theresidue was purified by column chromatography (silica gel, 0-100% EtOAc in petroleum ether) togive 21 (732 mg, 58.2% yield) as a yellow solid. LC-MS (ESI): m/z [M + 1]+ = 360.35
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-1,2,4-triazole, and friends who are interested can also refer to it.
Reference:
Article; Meuser, Megan E.; Rashad, Adel A.; Ozorowski, Gabriel; Dick, Alexej; Ward, Andrew B.; Cocklin, Simon; Molecules; vol. 24; 8; (2019);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics