One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 77-85-0, Name is 1,1,1-Tris(hydroxymethyl)ethane, formurla is C5H12O3. In a document, author is Kasemsuk, Teerapich, introducing its new discovery. Formula: C5H12O3.
A novel synthetic acanthoic acid analogues and their cytotoxic activity in cholangiocarcinoma cells
A novel series of acanthoic acid analogues containing triazole moiety were synthesized through esterification and CuAAC reaction. Evaluation of their biological activities against four cell lines of cholangiocarcinoma cells showed that 3d exhibited the strongest activity with an IC50 value of 18 mu M against KKU-213 cell line, which was 8 fold more potent than acanthoic acid. Interestingly, the triazole ring and nitro group on benzyl ring play very significant role in cytotoxic activity. The computational studies revealed that 3d occupies the binding energy of -12.7 and -10.8 kcal/mol with CDK-2 and EGFR protein kinases, respectively. This result might provide a beginning for the development of acanthoic acid analogues as an anticancer agent.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 77-85-0 help many people in the next few years. Formula: C5H12O3.