In an article, author is Laxio Arenas, Jose, once mentioned the application of 288-88-0, Product Details of 288-88-0, Name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, molecular weight is 69.0653, MDL number is MFCD00005228, category is Triazoles. Now introduce a scientific discovery about this category.
Fluorinated Triazole Foldamers: Folded or Extended Conformational Preferences
Fluorinated peptidomimetic foldamers are still in their infancy. We report here the easy access to fluorinated triazolamers based on 2-amino-3,3,3-trifluoropropyl-1,4-triazolyl acetic acid (CF3-1,4-Tz) and on aminomethyl-1,4-triazolyl-difluoroacetic acid (1,4-Tz-CF2). Both CF3-1,4-Tz and 1,4-Tz-CF2 amino acids were efficiently prepared by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Their conformational preferences were studied by 2D NMR analyses and molecular dynamic simulations. Foldamers based on CF3-1,4-Tz amino acids are capable of adopting short multi-stranded beta-sheet-like structures that are maintained by electrostatic interactions between the triazole proton and N2 atom of neighboring subunits. On the contrary, foldamers based on 1,4-Tz-CF2 units adopt elongated beta-strand-like structures, stabilized by electrostatic interaction between fluorine atoms and their neighboring protons.
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