Application of 27808-16-8,Some common heterocyclic compound, 27808-16-8, name is 4-Methyl-1H-1,2,3-triazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 5-chloro-6-methyl-pyrazolo [1,5-a] pyrimidine-3-carboxylic acid butyl 3rd (607 mg) for N, N- dimethyl formamide (39.8 ml) is added a solution of 4-methyl -1H-1, 2, 3-triazole (208 mg) and potassium carbonate (378 mg). The reaction mixture is stirred at room temperature for 2 hours, to be added, and the mixture is extracted with ethyl acetate. Extract water and saturated salt water cleaning, drying with anhydrous sodium sulfate, and the evaporation of the solvent under reduced pressure. Aid hemostasis by silica gel column chromatography purification (hexane/ethyl acetate), in order to produce the title compound (167 mg).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Methyl-1H-1,2,3-triazole, its application will become more common.
Reference:
Patent; TAKED A PHARMACEUTICAL COMPANY LIMITED; KAWASAKI, MASANORI; MIKAMI, SATOSHI; NAKAMURA, SHINJI; NEGORO, NOBUYUKI; IKEDA, SHUHEI; ASHIZAWA, TOMOKO; MARUI, SHOGO; TANIGUCHI, TAKAHIKO; (135 pag.)TW2016/520; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics