4314-22-1, name is 2-(1H-1,2,3-Triazol-1-yl)acetic acid, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 4314-22-1
To a stirred mixture of 5 (65 mg, 0.173 mmol), 1 – 1 ,2,3-triazoleacetic acid (6, 22 mg, 0.173 mmol), and Hunig’s base (0.091 mL, 0.522 mmol) in DMF (2 ml) was added HATU (66 mg, 0.174 mmol) and the reaction mixture was stirred for 30 min. The crude mixture was directly purified by prep. HPLC to give 7 (39 mg, 46%). -NMR (400MHz, d6-DMSO): 513.0 (s, IH), 8.34 (bs, IH), 8.16-8.1 1 (m, 2H), 8.00-7.95 (m, 2H), 7.71 (s, IH), 7.55-7.42 (m, 2H), 7.19 (q, IH), 5.51-5.43 (2s, 2H), 4.86-4.83 (m, 2H), 3.81-3.52 (m, 4H), 3.13-3.12 (2s, 3H), 3.04-2.97 (2s, 3H), 2.64-2.63 (2s, 3H). MS (EI) for C24H27N, ,0, found 486 (MH+).
Statistics shows that 4314-22-1 is playing an increasingly important role. we look forward to future research findings about 2-(1H-1,2,3-Triazol-1-yl)acetic acid.
Reference:
Patent; EXELIXIS, INC.; LEAHY, James, William; WO2012/37204; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics