288-36-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-36-8, name is 1H-1,2,3-Triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of 5-methyl-2-(2H-l,2,3-triazol-2-yl)benzoyl chloride 14 15 16To a solution of 2-iodo-5-methylbenzoic acid (14, 4.00 g, 15.3 mmol) in DMF (10 mL) was added 1,2,3-triazole (2.10 g, 30.5 mmol), cesium carbonate (9.95 g, 30.5 mmol), copper(I) iodide (0.145 g, 0.76 mmol) and trans -N,N’-dimethylcyclohexane-l,2-diamine (0.43 g, 3.05 mmol). The mixture was heated at 120 C for 10 min in a microwave reactor. The reaction was cooled to room temperature, diluted with water, and washed with EtOAc. The aqueous phase was acidified with 1 NHC1 and extracted with EtOAc. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The resultant residue was purified by silica gel chromatography (MeOH:DCM with 0.1% AcOH = 0: 1 to 1 :9) to give the faster eluting 2- (2H-l ,2,3-triazol-2-yl)-5-methylbenzoic acid (15), followed by the undesired regioisomer isomer, l-(2H-l,2,3-triazol-2-yl)-5-methylbenzoic acid (16).
The synthetic route of 1H-1,2,3-Triazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; DI MARCO, Christina; WO2013/59163; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics