Structure and biological activity of a binuclear Co(II) complex [Co2(Htda)2(H2O)6·5 H2O] was written by Li, Jian-jun;Li, Mei-yu;Gao, En-jun;Shen, Guang-hai. And the article was included in Shenyang Huagong Daxue Xuebao in 2014.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:
The complex [Co2(Htda)2(H2O)6·5H2O] (H3tda = 1H-1,2,3-triazole-4,5-dicarboxylic acid) was synthesized by hydrothermal method and characterized by x-ray anal. The binding of the title complex with calf thymus DNA (CT-DNA) was studied by fluorescence spectra. Gel electrophoresis assay and the optical d. scanning experiment demonstrated the ability to cleave the pBR322 DNA of the complex. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).
1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics