A simplified approach to N- and N,N’-linked 1,2,4-triazoles by transamination was written by Naik, Anil D.;Marchand-Brynaert, Jacqueline;Garcia, Yann. And the article was included in Synthesis in 2008.Application In Synthesis of 4-(4H-1,2,4-Triazol-4-yl)benzoic acid This article mentions the following:
A facile one-step procedure for the preparation of 4,4′-bis-1,2,4-triazole is reported. Direct transamination of N,N-dimethylformamide azine dihydrochloride by heating with 4-amino-1,2,4-triazole in refluxing benzene readily yields the target mol. in short duration of time with significant yield (73%). This catalyst-free method was extended to synthesize a series of 4-substituted 1,2,4-triazoles of potential interest in coordination chem. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Application In Synthesis of 4-(4H-1,2,4-Triazol-4-yl)benzoic acid).
4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Application In Synthesis of 4-(4H-1,2,4-Triazol-4-yl)benzoic acid
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics