New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-(2H-1,2,3-Triazol-2-yl)benzoic acid
Step (vii): tert-butyl N-{4-[(4-methoxyphenyl)methoxy]-2-[2-(2H-l,2,3-triazol-2- yl)benzamido]cyclopentyl}carbamate To a solution of ieri-butyl N-{2-amino-4-[(4- methoxyphenyl)methoxy]cyclopentyl}carbamate (1.71 g, 5.08 mmol) in dry DMF (17 ml) was added 2-(2H-l,2,3-triazol-2-yl)benzoic acid (CAS number 1001401 -62-2; 1.058 g, 5.59 mmol), HATU (2.90 g, 7.62 mmol) and triethylamine (2.125 ml, 15.25 mmol). The reaction was stirred at room temperature for 72 hours. The reaction was partitioned between ethyl acetate and water, washed with brine, dried over magnesium sulfate, concentrated in vacuo and purified by column chromatography (silica, 0-100% ethyl acetate / petrol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.37 (s, 9 H), 1.46 – 1.59 (m, 1 H), 1.58 – 1.77 (m, 1 H), 1.86 – 1.97 (m, 1 H), 2.18 – 2.37 (m, 1 H), 3.67 – 3.79 (m, 4 H), 3.83 – 4.01 (m, 2 H), 4.32 (s, 2 H), 6.85 – 6.95 (m, 2 H), 7.17 – 7.31 (m, 2 H), 7.44 – 7.54 (m, 2 H), 7.55 – 7.66 (m, 1 H), 7.76 (s, 1 H), 7.96 – 8.05 (m, 2 H)MS ES+: 508
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Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
1,2,3-Triazole – Wikipedia,
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