Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1H-[1,2,3]Triazole-4-carboxylic acid
[0839] lH-1,2,3-triazole-4-carboxylic acid (3.8 mg, 34f.tmol)was combined withHATU (12.9 mg, 34 flillOl) inDMF(2 mL) and stirred at room temperature for 15 minutes. Compound3 (13 mg, 31 f.tmol) and DIPEA (16 f.LL, 92 flillOl) werethen added. The solution was stirred at room temperature for15 minutes, at which time LCMS showed reaction completion. The solvent was removed in vacuo and the crude residuewas purified by reverse phase chromatography to yield Compoundb (15 mg) as a TFA salt. MS m/z [M+Ht calc’d forC25H29CIFN50 4 , 518.19. found 518.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 16681-70-2.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics