Day: February 9, 2023

Syntheses and crystal structures of copper(II) and nickel complexes with 1,2,3-triazole-carboxylic acid was written by Wang, Duo-Zhi;Bai, Mei;Zhang, Jian-Bin;Ma, Peng-Yuan. And the article was included in Chinese Journal of Structural Chemistry in 2012.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

Three novel complexes [Cu(L¹)₂(H₂O)₂] (1), [Ni(L¹)₂(H₂O)₂]·(H₂O)₄ (2, HL¹ = 5-methyl-1-(4-methylphenyl)-1,2,3-triazole-4-carboxylic acid) and [Ni₂(HL²)₂(CH₃OH)₆]·(CH₃OH)₂ (3, H₃L² = 1,2,3-triazole-4,5-dicarboxylic acid) were synthesized and characterized by elemental anal., IR and x-ray diffraction. Complexes 1 and 2 are mononuclear structures, and are assembled into a two-dimensional sheet by C(7)-H(7)···O(3) weak interactions or hydrogen-bonding interaction. Complex 3 is a centrosym. dinuclear structure, and is assembled into a three-dimensional supramol. structure by hydrogen-bonding interaction. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

catena-Poly[(chloridozinc)-μ-5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ido-κ²N¹:N³] was written by Sun, Chen-Guang;Song, Ji-Rong. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

In the title complex, [Zn(C₁₀H₈N₅)Cl]_n, the Zn^II ion is four-coordinated by one Cl atom and three N atoms from two in situ-generated deprotonated 5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ide ligands in a slightly distorted tetrahedral geometry. The Zn^II ions are bridged by the ligands, forming a helical chain along [001]. C-H···N and C-H···Cl H bonds and π-π interactions between the imidazole rings [centroid-centroid distance = 3.4244(10) Å] assemble the chains into a three-dimensional supramol. network. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Syntheses of D-arabinofuranosyl and 2′-deoxy-D-ribofuranosyl 1,2,3-triazolecarboxamides was written by Makabe, Osamu;Suzuki, Hiroshi;Umezawa, Sumio. And the article was included in Bulletin of the Chemical Society of Japan in 1977.Recommanded Product: 40594-98-7 This article mentions the following:

Several D-arabino- and 2′-deoxy-D-ribonucleosides of 1,2,3-triazolecarboxamides were synthesized by 2 methods, one involving acid-catalyzed fusion reactions of 1-O-acetyl-2,3,5-tri-O-benzyl-D-arabinofuranose or 1-O-acetyl-3,5-di-O-(p-nitrobenzoyl)-D-2-deoxyribofuranose with Et 1,2,3-triazole-4-carboxylate (I), and the other by glycosylation of the trimethylsilyl derivative of I with 2,3,5-tri-O-benzyl-D-arabinofuranosyl chloride or 3,5-di-O-(p-toluoyl)-D-2-deoxyribofuranosyl chloride. Evidence for the N-glycosylation sites (1 or 2 of triazole) and anomeric configurations of the resulting nucleosides is presented. Of the compounds prepared nucleosides II (R = H, OH) showed antiviral and cytotoxic activities (no data). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Recommanded Product: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Virtual Combinatorial Syntheses and Computational Screening of New Potential Anti-Herpes Compounds was written by de Julian-Ortiz, Jesus V.;Galvez, Jorge;Munoz-Collado, Carlos;Garcia-Domenech, Ramon;Gimeno-Cardona, Concepcion. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 4546-95-6 This article mentions the following:

The activity of new anti-HSV-1 chem. structures, designed by virtual combinatorial chem. synthesis and selected by a computational screening, is determined by an in vitro assay. A virtual library of phenol esters and anilides was formed from two databases of building blocks: one with carbonyl fragments and the other containing both substituted phenoxy and phenylamino fragments. The library of virtually assembled compounds was computationally screened, and those compounds which were selected by our math. model as active ones were finally synthesized and tested. Our antiviral activity model is a “tandem” of four linear functions of topol. graph-theor. descriptors. A given chem. structure was selected as active if it satisfies every discriminant equation in that model. The final result was that five new structures were selected, synthesized, and tested: all of them demonstrated activity, and three showed appreciable anti-HSV-1 activity, with IC₅₀ values of 0.9 μM. The same model, applied to a database of known compounds, has identified the anti-herpes activity of the following compounds: 3,5-dimethyl-4-nitroisoxazole, nitrofurantoin, 1-(pyrrolidinocarbonylmethyl)piperazine, nebularine, cordycepin, adipic acid, thymidine, α-thymidine, inosine, 2,4-diamino-6-(hydroxymethyl)pteridine, 7-(carboxymethoxy)-4-methylcoumarin, 5-methylcytidine, and others that showed less activity. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6HPLC of Formula: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.HPLC of Formula: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

3,4-Diamino-1,2,4-triazole based energetic salts: synthesis, characterization, and energetic properties was written by Wu, Jin-Ting;Zhang, Jian-Guo;Yin, Xin;Cheng, Zi-Yuan;Xu, Cai-Xia. And the article was included in New Journal of Chemistry in 2015.Synthetic Route of C4H3N3O4 This article mentions the following:

The protonation or metathesis synthesis and energetic properties of a new class of energetic materials, energetic salts of 3,4-diamino-triazole (DATr), are described. They were characterized by Fourier transform IR spectroscopy (FT-IR), elemental anal. (EA), differential scanning calorimetry (DSC), and X-ray single-crystal diffraction. The DSC results showed that these salts had acceptable thermal stabilities; the decomposition temperatures of these salts, except compound 3,4-Diamino-1,2,4-triazoliumnitro-formate, were over 200°. The d. of the series of salts ranged from 1.704 (3,4-Diamino-1,2,4-triazolium nitrate and 3,4-Diamino-1,2,4-triazolium picrate)-1.82 g cm^-3 (3,4-Diamino-1,2,4-triazolium trinitrophloroglucinate), placing them in a class of relatively dense compounds, and the heats of formation were calculated with the Gaussian 03 suite of programs. All the salts except 3,4-Diamino-1,2,4-triazolium 4,5-dicarboxylic-1,2,3-triazolate exhibited promising detonation performances (detonation pressure: 21.5-32.8 GPa, detonation velocity: 7017-8620 m s^-1), which were much higher than both those of TNT, and salt 3,4-Diamino-1,2,4-triazoliumnitro-formate was even comparable to RDX. Impact sensitivities were also determined by hammer tests and the results ranged from 8 J (sensitive) to > 40 J (insensitive). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics