Month: January 2023

Effective route for synthesis of novel aromatic pyridine derivates with polyamino polycarboxyl units was written by Gu, GuoLiang;Zhou, TaiYan. And the article was included in Journal of the Chemical Society of Pakistan in 2017.Computed Properties of C5H7N3O2 This article mentions the following:

A series of novel aromatic mols. with polyamino polycarboxyl were designed, synthesized and characterized in detail based on elemental anal., IR, mass, proton NMR spectroscopy. The synthetic route was optimized. The yield of second synthesis step over 91 % as a result of the catalyst (LiBr) used. Due to the fascinating structure with multiple N and O donor atoms, it may be potential applications in organic light emitting diodes (OLED). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Computed Properties of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Computed Properties of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction of 3-nitro- and 3-bromo-3-nitroacrylates with sodium azide was written by Anisimova, N. A.;Berestovitskaya, V. M.;Berkova, G. A.;Makarova, N. G.. And the article was included in Russian Journal of Organic Chemistry in 2007.Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate This article mentions the following:

Reactions of 3-nitro- and 3-bromo-3-nitroacrylates with NaN₃ proceed as 1,3-dipolar cycloaddition and lead to the formation of triazole- and nitrotriazolecarboxylates, and also of azido- and azidonitropropenoates. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Safety of Ethyl 1H-1,2,3-triazole-5-carboxylate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats was written by Parrish, Karen E.;Mao, Jialin;Chen, Jacob;Jaochico, Allan;Ly, Justin;Ho, Quynh;Mukadam, Sophie;Wright, Matthew. And the article was included in Biopharmaceutics & Drug Disposition in 2016.Related Products of 1614-12-6 This article mentions the following:

1-Aminobenzotriazole (ABT) is a non-isoform specific, time-dependent inhibitor of cytochrome P 450 (CYP) enzymes used extensively in preclin. studies to determine the relative contribution of oxidative metabolism Although ABT has been widely used, the extent and duration of its inhibitory effect is not well understood. The purpose of this study is to characterize ABT inhibition of CYP in rats at both the hepatic and intestinal levels. In vivo studies using midazolam (p.o. and i.v.), as a probe for CYP activity, demonstrated that CYP inhibition was not complete even at the highest dose (300 mg/kg). Addnl. in vivo studies demonstrated that even at 26 h following ABT administration, there was significant CYP inhibition remaining. In vitro studies, conducted in both rat liver microsomes and rat hepatocytes, confirm that ABT is a time-dependent inhibitor of rat CYP orthologs. However, in rat liver microsomes, there was more than 15% CYP activity remaining following a 60 min preincubation at 2 mM ABT and 5-10% of CYP activity was remaining in rat hepatocytes suspended in rat plasma following a 60 min preincubation at 2 mM ABT. 1-Aminobenzotriazole is a useful tool in elucidating the oxidative component of metabolism in preclin. species; however, conclusions made from the preclin. use of ABT should not operate under the assumption that CYP enzymic activity is completely inhibited. Copyright © 2016 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Related Products of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Related Products of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Assembly of a Complex Branched Oligosaccharide by Combining Fluorous-Supported Synthesis and Stereoselective Glycosylation using Anomeric Sulfonium Ions was written by Huang, Wei;Gao, Qi;Boons, Geert-Jan. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

There is an urgent need to develop reliable strategies for the rapid assembly of complex oligosaccharides. This paper presents a set of strategically selected orthogonal protecting groups, glycosyl donors modified by a (S)-phenylthiomethylbenzyl ether at C-2, and a glycosyl acceptor containing a fluorous tag, which makes it possible to rapidly prepare complex branched oligosaccharides of biol. importance. The C-2 auxiliary controlled the 1,2-cis anomeric selectivity of the various galactosylation. The orthogonal protecting groups, 2-naphthylmethyl ether (Nap) and levulinic ester (Lev), made it possible to generate glycosyl acceptors and allowed the installation of a crowded branching point. After the glycosylation, the chiral auxiliary could be removed using acidic conditions, which was compatible with the presence of the orthogonal protecting groups Lev and Nap, thereby allowing the efficient installation of 1,2-linked glycosides. The light fluorous tag made it possible to purify the compounds by a simple filtration method using silica gel modified by fluorocarbons. The set of building blocks was successfully employed for the preparation of the carbohydrate moiety of the GPI anchor of Trypanosoma brucei, which is a parasite that causes sleeping sickness in humans and similar diseases in domestic animals. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Salicylic acid biosynthesis inhibitors increase chilling injury to maize (Zea mays L.) seedlings was written by Wang, Yang;Wen, Tingting;Huang, Yutao;Guan, Yajing;Hu, Jin. And the article was included in Plant Growth Regulation in 2018.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Salicylic acid (SA) is involved in plant response to many abiotic stresses. This study investigated the potential role of SA in regulating chilling tolerance of maize (Zea mays L.) seedlings. The results showed that chilling stress induced transient accumulation of free SA in maize plants, and stimulated the enzymic activities of phenylalanine ammonia-lyase (PAL) and benzoic acid-2-hydroxylase. However, seedlings pretreated with SA biosynthesis inhibitors (i.e., 2-aminoindane-2-phosphonic acid or 1-aminobenzotriazole) accumulated significantly less free and bound SA and suffered more severe cold injury. Together, these results indicated that the chilling-induced SA accumulation in maize seedlings was mainly attributed to the PAL pathway. SA application also induced chilling tolerance of maize seedlings; whereas, inhibition of SA biosynthesis significantly increased membrane peroxidation, decreased antioxidant enzymes activities, and resulted in growth retardation. Exogenous SA treatments reversed the effects of the SA inhibitors on chilling tolerance, indicating the important endogenous role of SA in inducing chilling tolerance of maize plants. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazoles are compounds with a vast spectrum of applications, varying from materials (polymers), agricultural chemicals, pharmaceuticals, photoactive chemicals and dyes.Application In Synthesis of 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI was written by Kohn, Elise C.;Felder, Christian C.;Jacobs, William;Holmes, Katherine A.;Day, Alan;Freer, Richard;Liotta, Lance A.. And the article was included in Cancer Research in 1994.Application of 4546-95-6 This article mentions the following:

Evidence is accumulating that calcium homeostasis and calcium-regulated events may be selectively important in generation and maintenance of the malignant phenotype. CAI, a carboxyamido-triazole with a halogenated benzophenone tail, is a novel inhibitor of receptor-operated calcium influx and arachidonic acid release which inhibits malignant proliferation, invasion, and metastasis. The focus of this investigation was structural anal. of CAI and to determine if the inhibition of calcium influx and arachidonic acid release by CAI and its antiproliferative activity were mediated through the same chem. domains. Four families of mol. modifications of the CAI parent were synthesized: (I) modification or substitution of the triazole ring; (II) removal of the substituted benzophenone tail; (III) dehalogenation or partial truncation of the benzophenone moiety; and (IV) removal of the triazole and altered substitutions of the benzophenone tail. Compounds were tested for the inhibition of calcium influx and arachidonic acid release and inhibition of proliferation and colony formation in soft agar using the malignant CHO line transfected with the m5 muscarinic receptor and the A2058 human melanoma cell line. Only CAI and Group I compounds inhibited stimulated calcium influx, arachidonic acid release, and proliferation. Linear regression anal. of the relationship of the 50% inhibitory concentration values for all compounds in inhibition of calcium influx and arachidonate release was statistically significant (r² = 0.993). Similarly, a linear relationship was demonstrated between inhibition of calcium influx and inhibition of tumor cell proliferation (r² = 0.971). Groups II-IV had minimal or no signal or growth inhibitory activity. This investigation provides the first evidence for a coordinate link between calcium influx, calcium-mediated arachidonic acid release, and malignant proliferation and metastasis and constitutes the initial anal. of structurally important domains of the CAI mol. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeApplication of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Highly functionalized 3,4,5-trisubstituted 1,2,4-triazoles for future use as ligands in coordination polymers was written by Laessig, Daniel;Lincke, Joerg;Krautscheid, Harald. And the article was included in Tetrahedron Letters in 2010.Formula: C9H7N3O2 This article mentions the following:

An optimized synthesis of 3,4,5-trisubstituted 1,2,4-triazoles, which can be used as linkers for metal organic frameworks (MOFs), is described. The substituents in 3- and 5-position of the triazole have a significant impact on the torsion angles between the aromatic rings and therefore influence on solubility and coordination behavior of these ligands. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Formula: C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeFormula: C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tricyclic nitrogen-rich explosives with a planar backbone: bis(1,2,4-triazolyl)-1,2,3-triazoles as potential stable green gas generants was written by Gu, Hao;Cheng, Guangbin;Yang, Hongwei. And the article was included in New Journal of Chemistry in 2021.Synthetic Route of C4H3N3O4 This article mentions the following:

Two tricyclic nitrogen-rich compounds, 4,5-bis(5-nitro-1H-1,2,4-triazol-3-yl)-2H-1,2,3-triazole (4) and 4,5-bis(5-nitramino-1,2,4-triazole-3-yl)-2H-1,2,3-triazole (5), were obtained based on the combination of two different triazole heterocycles. The metal-free energetic salts (6-16) were synthesized with pos. heat of formation and good thermal stability. Among these salts, dicarbohydrazide salt 9 and triaminoguanidine salt 16 exhibit the relevant high detonation velocities (9: D = 8720 m s^-1 and 16: D = 8748 m s^-1) which are comparable to that of RDX (8795 m s^-1). Besides, the impact and friction sensitivities of compounds 4-16 (IS: 28-40 J, FS: 324-360 N) indicate that they have low sensitivities to mech. stimulations. The planar structure of crystal 4·3H₂O was confirmed by single crystal X-ray anal. In order to evaluate their gas production capacities, constant-volume combustion experiments were conducted on 9 and 16 with high gas production volume (≥ 840 dm³ kg^-1). The maximum gas-production pressures of 9 (P_max = 16.20 MPa) and 16 (P_max = 11.21 MPa) are much higher than that of commonly used gas generant guanidine nitrate (GN: P_max = 4.20 MPa). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A Method for Assessing Greener Alternatives between Chemical Products Following the 12 Principles of Green Chemistry was written by DeVierno Kreuder, Ashley;House-Knight, Tamara;Whitford, Jeffrey;Ponnusamy, Ettigounder;Miller, Patrick;Jesse, Nick;Rodenborn, Ryan;Sayag, Shlomo;Gebel, Malka;Aped, Inbal;Sharfstein, Israel;Manaster, Efrat;Ergaz, Itzhak;Harris, Angela;Nelowet Grice, Lisa. And the article was included in ACS Sustainable Chemistry & Engineering in 2017.Product Details of 1614-12-6 This article mentions the following:

Companies are interested in improving chems. to reduce environmental impacts, aka green chem. The 12 principles of green chem. outline a framework for identifying a greener chem. or process, spanning aspects in health hazard, ecol. risk, and resource efficiency across a product lifecycle. However, that framework does not detail how to measure performance. Collecting the data required, beyond simple health hazard ratings is resource intensive. This paper describes an approach for establishing green chem. metrics (GCM), to evaluate chems. and chem. processes against the 12 principles, using readily available data, such as the data compiled in compliance with the Globally Harmonized System of Classification and Labeling of Chems. (GHS). Using the GCM, chems. or processes can be ranked by a hierarchy of metrics: (1) scores for each of the 12 principles; (2) 3 category rankings between new and improved chems./processes (Improved Resource Use, Increased Energy Efficiency, and Reduced Human and Environmental Hazards); and (3) a summary comparison ranking. The GCM approach is unique in that it is robust and flexible enough to encompass a diverse product portfolio, inexpensive to implement with on-hand data, based on generally accepted industry practices, and allows meaningful communications about chem. sustainability options. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Product Details of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Product Details of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction between 1,2,3-triazole-4,5-dicarboxylic acid and the silver(I) cation was written by Capitan, F.;Salinas, F.;Alonso, E. J.. And the article was included in Boletin de la Sociedad Quimica del Peru in 1973.Category: triazoles This article mentions the following:

1,2,3-Triazole-4,5-dicarboxylic acid reacts with Ag(I) in aqueous HNO3 to give the mono-Ag salt, which has solubility product 1.45 × 10-9. The reaction was useful for determining Ag(I) by potentiometric (σ = ±0.0924) and conductometric (σ = ±0.0332) methods in the absence of Pb(II) and Hg(II), which interfere by forming white precipitates under the reaction conditions. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Category: triazoles).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics