Month: November 2022

Matsuda, Yoshiro published the artcileReaction of 4-amino-1,2,4-triazolium salts with polarized olefins, Name: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, the main research area is aminotriazolium salt cyclization polarized olefin; triazolium salt amino cyclization polarized olefin; betaine mesomeric preparation; triazolopyrazole preparation.

The reaction of 4-amino-1,2,4-triazolium salts I (R = Me, CH2Ph, X = iodo, Br) with polarized olefins EtOCH:CR1CO2Et (R1 = CO2Et, NO2) and (MeS)2C:CXY (X = CO2Me, Y = cyano) in the presence of K2CO3 in EtOH or DMSO directly yielded the back-donated 1,6-cyclization products, mesomeric betaines II (R1 = CO2Et, NO2, R2 = H; R1 = cyano, R2 = SMe) via N-vinylimino ylides, while the reaction of the salts I with polarized olefins (MeS)2C:CXY (X = H, Y = NO2; X = SO2Ph, Y = cyano) gave the 1,5-dipolar cyclization products, pyrazoles III and [1,2,4]-triazolo[4,3-b]pyrazole IV.

Heterocycles published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Name: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yuan, Shuo published the artcileBronsted acid-promoted ‘on-water’ C(sp3)-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is trimethoxyphenyl triazolopyrimidinyl methyl isoindolinone preparation SKP2 CKS1 inhibition SAR.

An efficient Bronsted acid-promoted C(sp3)-H functionalization approach that enabled the rapid construction of biol. important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines was reported. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond and two C-N bonds were formed simultaneously with high atom economy. It was concluded that the Me group linked to the electron-deficient N-heterocycles was used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chem. Besides, the title compounds exhibited promising activity against the SKP2-CKS1 interaction.

Chinese Chemical Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Liu, Luxiao published the artcileDeep eutectic solvent promoted one-pot synthesis of nitriles from alcohols, Category: triazoles, the main research area is aryl nitrile green preparation; alc tandem aerobic oxidation condensation deep eutectic solvent.

Various aryl nitriles RCN [R = Ph, 4-BrC6H4, 2-thienyl, etc.] were readily synthesized from aerobic oxidation of substituted benzyl alcs. in deep eutectic solvent composed of choline chloride and p-toluenesulfonic acid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl, followed by condensation with hydroxylamine hydrochloride. High yields of corresponding nitriles had obtained under mild reactions conditions. This strategy belonged to a novel and environmentally benign transition-metal-free one-pot cascade process for the synthesis of nitriles.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, Category: triazoles.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hu, Yongke published the artcileDirect oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions, SDS of cas: 143426-50-0, the main research area is PdBi bimetallic catalyzed oxidative esterification alc; aryl ester preparation PdBi bimetallic catalyzed oxidative esterification.

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production

Journal of Materials Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, SDS of cas: 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lou, Ji-Cong published the artcileMetal-Free Oxidation of Trichloroacetimidates to Aldehydes, HPLC of Formula: 143426-50-0, the main research area is alc trichloroacetonitrile DBU imidation; trichloroacetimidate preparation dimethylsulfoxide oxidation; carbonyl compound preparation.

A metal-free oxidation reaction of trichloroacetimidates to aldehydes or ketones with DMSO as an oxidant was reported. The reaction exhibited a broad range of functional group tolerance. Detailed mechanistic studies were performed with the aid of NMR, in-situ IR spectroscopy, GC-MS anal. and 18O-labeling experiments

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, HPLC of Formula: 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Jishkariani, Davit published the artcileCu(I)-Catalyzed Regioselective Synthesis of Pyrazolo[5,1-c]-1,2,4-triazoles, SDS of cas: 39602-93-2, the main research area is terminal alkyne triazolium imide regioselective cycloaddition copper; regioselective preparation; copper regioselective cycloaddition catalyst.

Cycloadditions of terminal alkynes to 1,2,4-triazolium N-imides in the presence of base and Cu(I) afford pyrazolo[5,1-c]-1,2,4-triazoles, e.g., I, regioselectively. The scope of alkynes, the influence of the electronic nature of the leaving group, and variations in the 1-alkyl substituent were examined Quantum chem. calculations were employed to explain the distinct reactivity of the propiolates.

Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, SDS of cas: 39602-93-2.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Larson, Helen published the artcileNi-Catalyzed C-H Arylation of Oxazoles and Benzoxazoles Using Pharmaceutically Relevant Aryl Chlorides and Bromides, Synthetic Route of 108281-78-3, the main research area is nickel catalyst arylation oxazole benzoxazole pharmaceutically relevant aryl halide.

This manuscript details the development of the nickel-catalyzed arylation of oxazoles and benzoxazoles with aryl halides. A series of aryl, heteroaryl, and druglike electrophiles relevant to pharmaceutical applications were surveyed. The desired arylated products were obtained in synthetically useful yields using electronically and structurally varied aryl halides. The use of microscale high-throughput experimentation was essential for both the rapid identification of optimal reaction parameters and the investigation of the aryl halide scope.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 108281-78-3 belongs to class triazoles, name is 6-Bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine, and the molecular formula is C7H6BrN3, Synthetic Route of 108281-78-3.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Panmand, Deepak S. published the artcileSynthesis and Direct C2 Functionalization of Imidazolium and 1,2,4-Triazolium N-Imides, Recommanded Product: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, the main research area is aryl imidazolpyrazolole pyrazolotriazole imidazoliumylamide triazoliumylamide preparation fluorescence emission spectra; azoliumimide acetylene aryl iodide arylation alkynylation cyclization.

Pd-catalyzed direct C2 arylation and Cu-catalyzed direct one-pot alkynylation/intramol. cyclization of azolium N-imides are reported. Various acetylenes, aryl iodides, and 1-alkyl substituents were examined The mild protocol allows direct C2 arylation of azolium N-imides without the use of specialized reagents together with novel one-pot regioselective preparations of imidazole-pyrazolo e. g., I, and pyrazolo-1,2,4-triazole e. g., II ring systems. The electronic properties of selected examples were examined by fluorescence spectroscopy.

Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Recommanded Product: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Campos, Joana F. published the artcileEucalyptol as new solvent for the synthesis of heterocycles containing oxygen, sulfur and nitrogen, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is fused heterocyclic compound one pot preparation green chem.

The first investigation of the use of eucalyptol as a new solvent for organic transformations was reported. Heterocycles containing oxygen, sulfur and nitrogen were chosen as targets or as starting materials for widely used palladium-catalyzed cross-coupling reactions, i.e. Suzuki-Miyaura and Sonogashira-Hagihara reactions. Eucalyptol turned out to be a viable sustainable alternative to common solvents.

Green Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Fuerstner, Alois published the artcileIron-Catalyzed Cross-Coupling Reactions, Quality Control of 24415-66-5, the main research area is iron complex cross coupling catalyst organometallic compound; aryl chloride triflate tosylate coupling iron catalyst; heteroaryl chloride triflate tosylate coupling iron catalyst; green chem iron complex cross coupling catalyst.

Simple iron salts such as FeCln, Fe(acac)n (n = 2,3) or the salen complex I turned out to be highly efficient, cheap, toxicol. benign, and environmentally friendly precatalysts for a host of cross-coupling reactions of alkyl or aryl Grignard reagents, zincates, or organomanganese species with aryl and heteroaryl chlorides, triflates, and even tosylates. An “”inorganic Grignard reagent”” of the formal composition [Fe(MgX)2], prepared in situ, likely constitutes the propagating species responsible for the catalytic turnover, which occurs in many cases at an unprecedented rate even at or below room temperature Because of the exceptionally mild reaction conditions, a series of functional groups such as esters, ethers, nitriles, sulfonates, sulfonamides, thioethers, acetals, alkynes, and -CF3 groups are compatible. The method also allows for consecutive cross-coupling processes in one pot, as exemplified by the efficient preparation of compound II, and has been applied to the first synthesis of the cytotoxic marine natural product montipyridine (III). In contrast to the clean reaction of (hetero)aryl chlorides, the corresponding bromides and iodides are prone to a reduction of their C-X bonds in the presence of the iron catalyst.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Quality Control of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics